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Original Article

Safety and effectiveness of iguratimod in patients with rheumatoid arthritis: Final report of a 52-week, multicenter postmarketing surveillance study

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Pages 314-323 | Received 02 Feb 2018, Accepted 29 Mar 2018, Published online: 27 Apr 2018

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Read on this site (4)

Q Shao, S Wang, H Jiang & L Liu. (2021) Efficacy and safety of iguratimod on patients with primary Sjögren’s syndrome: a randomized, placebo-controlled clinical trial. Scandinavian Journal of Rheumatology 50:2, pages 143-152.
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Naoki Ishiguro, Kai Shibata, Akiko Yoshimura, Satoshi Ikeuchi & Mika Ishii. (2020) Investigation of the predictors of the response to Iguratimod therapy: A post-hoc analysis of post-marketing surveillance study. Modern Rheumatology 30:4, pages 626-632.
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Yuji Nozaki, Asuka Inoue, Koji Kinoshita, Masanori Funauchi & Itaru Matsumura. (2020) Efficacy of iguratimod vs. salazosulfapyridine as the first-line csDMARD for rheumatoid arthritis. Modern Rheumatology 30:2, pages 249-258.
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Articles from other publishers (27)

Yuyi Xu, Ming Zhao, Jinxue Cao, Ting Fang, Jian Zhang, Yanli Zhen, Fangling Wu, Xiaohui Yu, Yaming Liu, Ji Li & Dongkai Wang. (2023) Applications and recent advances in transdermal drug delivery systems for the treatment of rheumatoid arthritis. Acta Pharmaceutica Sinica B 13:11, pages 4417-4441.
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Satoshi Nagata, Ryo Yamasaki, Ezgi Ozdemir Takase, Kotaro Iida, Mitsuru Watanabe, Katsuhisa Masaki, Marion Heleen Cathérine Wijering, Hiroo Yamaguchi, Jun-ichi Kira & Noriko Isobe. (2023) Iguratimod Ameliorates the Severity of Secondary Progressive Multiple Sclerosis in Model Mice by Directly Inhibiting IL-6 Production and Th17 Cell Migration via Mitigation of Glial Inflammation. Biology 12:9, pages 1217.
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Taibiao Lyu, Hui Jiang, Liuting Zeng, Suying Liu, Chengmei He, Chaowen Luo, Lin Qiao, Yan Zhao & Hua Chen. (2023) Iguratimod suppresses Tfh cell differentiation in primary Sjögren’s syndrome patients through inhibiting Akt/mTOR/STAT3 signaling. Arthritis Research & Therapy 25:1.
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Qingran Yan, Bei Liu, Jieying Wang, Hanlin Yin, Qianqian Li & Liangjing Lu. (2023) Iguratimod as an alternative therapy for systemic sclerosis and prevention of the occurrence of ischemic digital ulcer. Frontiers in Medicine 10.
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Yuji Nozaki, Motohiro Oribe, Daisuke Tomita, Tetsu Itami, Shinya Hayashi, Toshihisa Maeda, Koji Fukuda, Ryosuke Kuroda, Keiko Funahashi, Tsukasa Matsubara, Koji Kinoshita & Itaru Matsumura. (2023) Iguratimod versus salazosulfapyridine in rheumatoid arthritis patients with an inadequate response to methotrexate: Adjusted with propensity score matching. Modern Rheumatology 33:3, pages 472-480.
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Dan Ouyang, Yuan Zhi Ma, Jie Zou, Yong Long Wang, Zheng Chen, Yu Ying Yang, Bin Zou, Xin Li & Jian Zhong Cao. (2022) Effectiveness and Safety of Iguratimod Monotherapy or Combined With Methotrexate in Treating Rheumatoid Arthritis: A Systematic Review and Meta-Analysis. Frontiers in Pharmacology 13.
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Liuting Zeng, Qi He, Kailin Yang, Wensa Hao, Ganpeng Yu & Hua Chen. (2022) A Systematic Review and Meta-Analysis of 19 Randomized Controlled Trials of Iguratimod Combined With Other Therapies for Sjogren’s Syndrome. Frontiers in Immunology 13.
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Liuting Zeng, Ganpeng Yu, Kailin Yang, Wensa Hao & Hua Chen. (2022) The Effect and Safety of Iguratimod Combined With Methotrexate on Rheumatoid Arthritis: A Systematic Review and Meta-Analysis Based on a Randomized Controlled Trial. Frontiers in Pharmacology 12.
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Chao-Jun Hu, Li Zhang, Shuang Zhou, Nan Jiang, Jiu-Liang Zhao, Qian Wang, Xin-Ping Tian & Xiao-Feng Zeng. (2021) Effectiveness of iguratimod as monotherapy or combined therapy in patients with rheumatoid arthritis: a systematic review and meta-analysis of RCTs. Journal of Orthopaedic Surgery and Research 16:1.
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Tao Zhang, Chao Ma, Zhiqiang Zhang, Huiyuan Zhang & Hongbo Hu. (2021) NF‐κB signaling in inflammation and cancer. MedComm 2:4, pages 618-653.
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Jingya Tan, Jiaqiang Dan & Yi Liu. (2021) Clinical Efficacy of Methotrexate Combined with Iguratimod on Patients with Rheumatoid Arthritis and Its Influence on the Expression Levels of HOTAIR in Serum. BioMed Research International 2021, pages 1-7.
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Kai Shibata, Akiko Yoshimura, Satoshi Ikeuchi & Mika Ishii. (2021) Effectiveness of drug safety measures for reducing the incidence of adverse drug reactions: Post-hoc analysis of data from all-case surveillance of iguratimod using generalized estimating equations. PLOS ONE 16:7, pages e0253513.
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Yan Li, Kunpeng Li, Zheng Zhao, Yanyan Wang, Jingyu Jin, Junhua Guo, Jie Zhang, Jianglin Zhang, Jian Zhu & Feng Huang. (2021) Randomised, Double-Blind, Placebo-Controlled Study of Iguratimod in the Treatment of Active Spondyloarthritis. Frontiers in Medicine 8.
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Yuji Nozaki. (2021) Iguratimod: Novel Molecular Insights and a New csDMARD for Rheumatoid Arthritis, from Japan to the World. Life 11:5, pages 457.
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Masao Tanaka. (2021) Conflict between efficacy and economy in rheumatoid arthritis treatment: Iguratimod is found at a compromise. The Lancet Regional Health - Western Pacific 10, pages 100144.
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Rong Mu, Chun Li, Xiaomei Li, Yao Ke, Ling Zhao, Lin Chen, Rui Wu, Zhenbiao Wu, Xiaoxia Zuo, Yanli Xie, Jinwei Chen, Wei Wei, Yi Liu, Zhijun Li, Lie Dai, Lingyun Sun, Xiangyuan Liu & Zhanguo Li. (2021) Effectiveness and safety of iguratimod treatment in patients with active rheumatoid arthritis in Chinese: A nationwide, prospective real-world study. The Lancet Regional Health - Western Pacific 10, pages 100128.
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Chang-hong Li, Zhen-zhen Ma, Lei-lei Jian, Xin-yu Wang, Lin Sun, Xiang-yuan Liu, Zhong-qiang Yao & Jin-xia Zhao. (2021) Iguratimod inhibits osteoclastogenesis by modulating the RANKL and TNF-α signaling pathways. International Immunopharmacology 90, pages 107219.
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Yuening Kang, Qingran Yan, Qiong Fu, Ran Wang, Min Dai, Fang Du, Qing Dai, Ping Ye, Chunmei Wu, Liangjing Lu & Chunde Bao. (2020) Iguratimod as an alternative induction therapy for refractory lupus nephritis: a preliminary investigational study. Arthritis Research & Therapy 22:1.
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Asuka Inoue, Yuji Nozaki, Yasuaki Hirooka, Koji Kinoshita, Yasutaka Chiba, Masanori Funauchi & Itaru Matsumura. (2020) The Effectiveness and Retention Rate of Iguratimod in Japanese Rheumatoid Arthritis Patients with/without Methotrexate in Daily Medical Care. Life 10:11, pages 261.
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Bingtong Li, Ping Li & Liqi Bi. (2019) Iguratimod dose dependently inhibits the expression of citrullinated proteins and peptidylarginine deiminases 2 and 4 in neutrophils from rheumatoid arthritis patients. Clinical Rheumatology 39:3, pages 899-907.
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Sisi Xie, Shu Li, Jing Tian & Fen Li. (2020) Iguratimod as a New Drug for Rheumatoid Arthritis: Current Landscape. Frontiers in Pharmacology 11.
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Huihui Jiang, Hongyan Gao, Qin Wang, Miao Wang & Bin Wu. (2020) Molecular mechanisms and clinical application of Iguratimod: A review. Biomedicine & Pharmacotherapy 122, pages 109704.
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Eijiro Jimi, Nana Takakura, Fumitaka Hiura, Ichiro Nakamura & Shizu Hirata-Tsuchiya. (2019) The Role of NF-κB in Physiological Bone Development and Inflammatory Bone Diseases: Is NF-κB Inhibition “Killing Two Birds with One Stone”?. Cells 8:12, pages 1636.
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Yan Ye, Mei Liu, Longhai Tang, Fang Du, Yuanhua Liu, Pei Hao, Qiong Fu, Qiang Guo, Qingran Yan, Xiaoming Zhang & Chunde Bao. (2019) Iguratimod represses B cell terminal differentiation linked with the inhibition of PKC/EGR1 axis. Arthritis Research & Therapy 21:1.
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François Vercruysse, Thomas Barnetche, Estibaliz Lazaro, Emilie Shipley, François Lifermann, Alexandre Balageas, Xavier Delbrel, Bruno Fautrel, Christophe Richez, Thierry Schaeverbeke & Marie-Elise Truchetet. (2019) Adult-onset Still’s disease biological treatment strategy may depend on the phenotypic dichotomy. Arthritis Research & Therapy 21:1.
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Jie Li, Jun Bao, Jian Zeng, Aizhu Yan, Chunqiu Zhao & Qiang Shu. (2019) Iguratimod: a valuable remedy from the Asia Pacific region for ameliorating autoimmune diseases and protecting bone physiology. Bone Research 7:1.
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. (2019) Iguratimod/warfarin. Reactions Weekly 1748:1, pages 246-246.
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