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Review

Exploiting the pro-apoptotic function of NOXA as a therapeutic modality in cancer

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Pages 767-779 | Received 23 Jan 2017, Accepted 28 Jun 2017, Published online: 18 Jul 2017

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Lei Zhao, Lina Fu, Zhongwei Xu, Rong Fan, Ruicheng Xu, Rong Fu, Shuang Zou, Congcong Wang, Yan Zhang, Jiabao Wang, Jun Bao, Zhimei Wang, Xiaojie Hou, Yupiao Zheng, Erqing Dai & Fengmei Wang. (2019) The anticancer effects of cinobufagin on hepatocellular carcinoma Huh‑7�cells are associated with activation of the p73 signaling pathway. Molecular Medicine Reports.
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Lizhong Liang, Junquan Weng, Yingying You, Qifen He, Yunping Fan & Guiqing Liao. (2019) Role of Noxa in proliferation, apoptosis, and autophagy in human adenoid cystic carcinoma. Journal of Oral Pathology & Medicine 48:1, pages 52-59.
Crossref
Ahmet Can Timucin, Huveyda Basaga & Ozgur Kutuk. (2019) Selective targeting of antiapoptotic BCL-2 proteins in cancer. Medicinal Research Reviews 39:1, pages 146-175.
Crossref
Tao Hu, Jingyang Zhang, Beibei Sha, Miaomiao Li, Longhao Wang, Yi Zhang, Xingge Liu, Ziming Dong, Zhenzhen Liu, Pei Li & Ping Chen. (2018) Targeting the overexpressed USP7 inhibits esophageal squamous cell carcinoma cell growth by inducing NOXA‐mediated apoptosis. Molecular Carcinogenesis 58:1, pages 42-54.
Crossref
Lisett Contreras, Ruben I. Calderon, Armando Varela-Ramirez, Hong-Yu Zhang, Yuan Quan, Umashankar Das, Jonathan R. Dimmock, Rachid Skouta & Renato J. Aguilera. (2018) Induction of apoptosis via proteasome inhibition in leukemia/lymphoma cells by two potent piperidones. Cellular Oncology 41:6, pages 623-636.
Crossref
Nazanin Fathi, Golnaz Rashidi, Ali Khodadadi, Shahriar Shahi & Simin Sharifi. (2018) STAT3 and apoptosis challenges in cancer. International Journal of Biological Macromolecules 117, pages 993-1001.
Crossref
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Crossref
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Crossref
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