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Expert Review of Molecular Diagnostics Volume 18, 2018 - Issue 9
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Review

Biomarkers of drug-induced liver injury: progress and utility in research, medicine, and regulation

Mitchell R. McGillDepartment of Environmental and Occupational Health, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, USA;Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USAView further author information
&
Hartmut JaeschkeDepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USACorrespondence[email protected]
View further author information
Pages 797-807 | Received 28 Apr 2018, Accepted 03 Aug 2018, Published online: 13 Aug 2018

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Rebecca Allison, Asha Guraka, Isaac Thom Shawa, Gyan Tripathi, Wolfgang Moritz & Ali Kermanizadeh. (2023) Drug induced liver injury – a 2023 update. Journal of Toxicology and Environmental Health, Part B 26:8, pages 442-467.
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Daniel E. Di Zeo-Sánchez, Antonio Segovia-Zafra, Gonzalo Matilla-Cabello, José M. Pinazo-Bandera, Raúl J. Andrade, M. Isabel Lucena & Marina Villanueva-Paz. (2022) Modeling drug-induced liver injury: current status and future prospects. Expert Opinion on Drug Metabolism & Toxicology 18:9, pages 555-573.
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Ruili Yu, Yingli Yu, Shijia Su, Lin Zhao, Qin Wang, Yue Zhang, Lei Song & Kun Zhou. (2022) Psoralen induces liver injuries through endoplasmic reticulum stress signaling in female mice. Drug and Chemical Toxicology 45:4, pages 1818-1824.
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David S. Umbaugh & Hartmut Jaeschke. (2021) Biomarkers of drug-induced liver injury: a mechanistic perspective through acetaminophen hepatotoxicity. Expert Review of Gastroenterology & Hepatology 15:4, pages 363-375.
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Articles from other publishers (25)

Bei He, Xuan Cheng, Huai‐Rong Xiang, Yun Li, Qi‐Zhi Zhang, Wen‐Xing Peng & Bo Yang. (2023) Glutamate dehydrogenase combined with ferrochelatase as a biomarker of liver injury induced by antituberculosis drugs. British Journal of Clinical Pharmacology 89:10, pages 3092-3104.
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Mitchell R. McGill. 2023. Biomarkers in Toxicology. Biomarkers in Toxicology 223 242 .
Alyaa S. Abdel Halim, Hassan Ahmed Rudayni, Anis Ahmad Chaudhary & Mohamed A. M. Ali. (2022) MicroRNAs: Small molecules with big impacts in liver injury. Journal of Cellular Physiology 238:1, pages 32-69.
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Claire Harrington, Swathi Krishnan, Cara L. Mack, Paolo Cravedi, David N. Assis & Josh Levitsky. (2022) Noninvasive biomarkers for the diagnosis and management of autoimmune hepatitis. Hepatology 76:6, pages 1862-1879.
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Samuel James Offor, Cecilia Nwadiuto Amadi, Ifeyinwa Chijioke-Nwauche, Jose E. Manautou & Orish E. Orisakwe. (2022) Potential deleterious effects of paracetamol dose regime used in Nigeria versus that of the United States of America. Toxicology Reports 9, pages 1035-1044.
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Mitchell R. McGill. 2022. Biomarkers in Toxicology. Biomarkers in Toxicology 1 20 .
Joel H. Vazquez & Mitchell R. McGill. (2021) Redrawing the Map to Novel DILI Biomarkers in Circulation: Where Are We, Where Should We Go, and How Can We Get There?. Livers 1:4, pages 286-293.
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Peter M. Abuja, Kurt Zatloukal & Helmut Denk. (2021) Priming, Triggering, Adaptation and Senescence (PTAS): A Hypothesis for a Common Damage Mechanism of Steatohepatitis. International Journal of Molecular Sciences 22:22, pages 12545.
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Ying Li, Zheming Guo, Haipeng Cui, Tu Wang, Yuhang Xu & Juan Zhao. (2021) Urantide prevents CCl4‑induced acute liver injury in rats by regulating the MAPK signalling pathway. Molecular Medicine Reports 24:4.
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Anamarija Kovač Peić, Martina Šrajer Gajdošik, Kate Brilliant, Helen Callanan, Douglas C. Hixson, Marija Begić & Djuro Josić. (2021) Changes in the proteome of extracellular vesicles shed by rat liver after subtoxic exposure to acetaminophen. ELECTROPHORESIS 42:12-13, pages 1388-1398.
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Tao Liu, Manman Tian, Jiayue Wang, Xiangge Tian, Jihong Liu, Lei Feng, Xiaochi Ma & Jingnan Cui. (2021) Rational design of a fluorescent probe for the detection of LAP and its application in drug-induced liver injury. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 251, pages 119362.
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Marina Villanueva-Paz, Laura Morán, Nuria López-Alcántara, Cristiana Freixo, Raúl J. Andrade, M Isabel Lucena & Francisco Javier Cubero. (2021) Oxidative Stress in Drug-Induced Liver Injury (DILI): From Mechanisms to Biomarkers for Use in Clinical Practice. Antioxidants 10:3, pages 390.
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Sara Seife Hassen, Fateen Ata, Ammara Bint I Bilal, Mohamed Salih Ali, Mahir Petkar, Abdelnaser Y. Awad Elzouki & Muhammad Zahid. (2020) Immune‐mediated drug‐induced liver injury secondary to Omeprazole: A case report. Clinical Case Reports 8:12, pages 3420-3425.
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Lu Liu, Li Zhang, Longjiang Li, Mengting Chen, Zhe Wang, Yi Shen, Jiayi Huang & Ling Tang. (2020) Sleep deprivation aggravated lipopolysaccharide/d-galactosamine-induced acute liver injury by suppressing melatonin production. Inflammation Research 69:11, pages 1133-1142.
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Silvio Terra Stefanello, Nelson Rodrigues de Carvalho, Simone Beder Reis, Felix Alexandre Antunes Soares & Rômulo Pillon Barcelos. (2020) Acetaminophen Oxidation and Inflammatory Markers – A Review of Hepatic Molecular Mechanisms and Preclinical Studies. Current Drug Targets 21:12, pages 1225-1236.
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Andrew K. Smith, Glen E. P. Ropella, Mitchell R. McGill, Preethi Krishnan, Lopamudra Dutta, Ryan C. Kennedy, Hartmut Jaeschke & C. Anthony Hunt. (2020) Contrasting model mechanisms of alanine aminotransferase (ALT) release from damaged and necrotic hepatocytes as an example of general biomarker mechanisms. PLOS Computational Biology 16:6, pages e1007622.
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Noppadol Chanhom, Wanvisa Udomsinprasert, Usa Chaikledkaew, Surakameth Mahasirimongkol, Sukanya Wattanapokayakit & Jiraphun Jittikoon. (2020) GSTM1 and GSTT1 genetic polymorphisms and their association with antituberculosis drug‑induced liver injury. Biomedical Reports.
Crossref
Joel H Vazquez, Melissa M Clemens, Felicia D Allard, Eric U Yee, Stefanie Kennon-McGill, Samuel G Mackintosh, Hartmut Jaeschke, Michael D Hambuchen & Mitchell R McGill. (2020) Identification of Serum Biomarkers to Distinguish Hazardous and Benign Aminotransferase Elevations. Toxicological Sciences 173:2, pages 244-254.
Crossref
Laura P. James, Mitchell R. McGill, Dean W. Roberts, Jack A. Hinson & William M. Lee. 2020. 35 50 .
Ireneusz P. Grudzinski, Monika Ruzycka, Andrzej Cieszanowski, Wojciech Szeszkowski, Iwona Badurek, Anna Malkowska & Magdalena Bamburowicz-Klimkowska. (2019) MRI-based preclinical discovery of DILI: A lesson from paracetamol-induced hepatotoxicity. Regulatory Toxicology and Pharmacology 108, pages 104478.
Crossref
Mitchell R. McGill & Hartmut Jaeschke. (2019) Animal models of drug-induced liver injury. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1865:5, pages 1031-1039.
Crossref
Mark Real, Michele S. Barnhill, Cory Higley, Jessica Rosenberg & James H. Lewis. (2018) Drug-Induced Liver Injury: Highlights of the Recent Literature. Drug Safety 42:3, pages 365-387.
Crossref
Luqi Duan, Anup Ramachandran, Jephte Y. Akakpo, James L. Weemhoff, Steven C. Curry & Hartmut Jaeschke. (2019) Role of extracellular vesicles in release of protein adducts after acetaminophen-induced liver injury in mice and humans. Toxicology Letters 301, pages 125-132.
Crossref
Mitchell R. McGill & Hartmut Jaeschke. 2019. Drug-induced Liver Injury. Drug-induced Liver Injury 221 239 .
Anup Ramachandran & Hartmut Jaeschke. 2019. Drug-induced Liver Injury. Drug-induced Liver Injury 195 219 .

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