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Expert Review of Neurotherapeutics Volume 18, 2018 - Issue 11
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Review

BACE inhibitors in clinical development for the treatment of Alzheimer’s disease

Francesco PanzaNeurodegenerative Disease Unit, Department of Basic Medicine, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy;Department of Clinical Research in Neurology, Neurodegenerative Disease Unit, University of Bari Aldo Moro, Lecce, Italy;Geriatric Unit, Fondazione IRCCS “Casa Sollievo della Sofferenza”, San Giovanni Rotondo, Foggia, ItalyCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-7220-0656View further author information
ORCID Icon,
Madia LozuponeNeurodegenerative Disease Unit, Department of Basic Medicine, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, ItalyView further author information
,
Vincenzo SolfrizziInterdisciplinary Department of Medicine, Geriatric Medicine-Memory Unit and Rare Disease Centre, University of Bari ‘Aldo Moro’, Bari, ItalyView further author information
,
Rodolfo SardoneNational Institute of Gastroenterology “Saverio de Bellis”, Research Hospital, Castellana Grotte Bari, ItalyView further author information
,
Carla PiccininniNational Institute of Gastroenterology “Saverio de Bellis”, Research Hospital, Castellana Grotte Bari, Italy;Psychiatric Unit, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, ItalyView further author information
,
Vittorio DibelloInterdisciplinary Department of Medicine (DIM), Section of Dentistry, University of Bari Aldo, Moro, Bari, ItalyView further author information
,
Roberta StalloneNeurodegenerative Disease Unit, Department of Basic Medicine, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy;National Institute of Gastroenterology “Saverio de Bellis”, Research Hospital, Castellana Grotte Bari, ItalyView further author information
,
Gianluigi GiannelliNational Institute of Gastroenterology “Saverio de Bellis”, Research Hospital, Castellana Grotte Bari, ItalyView further author information
,
Antonello BellomoPsychiatric Unit, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, ItalyView further author information
,
Antonio GrecoGeriatric Unit, Fondazione IRCCS “Casa Sollievo della Sofferenza”, San Giovanni Rotondo, Foggia, ItalyView further author information
,
Antonio DanieleInstitute of Neurology, Catholic University of Sacred Heart, Rome, Italy;Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, ItalyView further author information
,
Davide SeripaGeriatric Unit, Fondazione IRCCS “Casa Sollievo della Sofferenza”, San Giovanni Rotondo, Foggia, ItalyView further author information
,
Giancarlo LogroscinoNeurodegenerative Disease Unit, Department of Basic Medicine, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy;Department of Clinical Research in Neurology, Neurodegenerative Disease Unit, University of Bari Aldo Moro, Lecce, ItalyORCID Iconhttp://orcid.org/0000-0003-0423-3242View further author information
ORCID Icon &
Bruno P. ImbimboDepartment of Research and Development, Chiesi Farmaceutici, Parma, ItalyView further author information
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Pages 847-857 | Received 28 Jul 2018, Accepted 01 Oct 2018, Published online: 24 Oct 2018

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Simone Salemme, Antonio Ancidoni, Nicoletta Locuratolo, Paola Piscopo, Eleonora Lacorte, Marco Canevelli & Nicola Vanacore. (2023) Advances in amyloid-targeting monoclonal antibodies for Alzheimer’s disease: clinical and public health issues. Expert Review of Neurotherapeutics 0:0, pages 1-17.
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Francesco Panza, Maddalena La Montagna, Luisa Lampignano, Roberta Zupo, Ilaria Bortone, Fabio Castellana, Rodolfo Sardone, Luisa Borraccino, Vittorio Dibello, Emanuela Resta, Mario Altamura, Antonio Daniele & Madia Lozupone. (2021) Vitamin D in the development and progression of alzheimer’s disease: implications for clinical management. Expert Review of Neurotherapeutics 21:3, pages 287-301.
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Natalia Szałaj, Justyna Godyń, Jakub Jończyk, Anna Pasieka, Dawid Panek, Tomasz Wichur, Krzysztof Więckowski, Paula Zaręba, Marek Bajda, Anja Pislar, Barbara Malawska, Raimon Sabate & Anna Więckowska. (2020) Multidirectional in vitro and in cellulo studies as a tool for identification of multi-target-directed ligands aiming at symptoms and causes of Alzheimer’s disease. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 1944-1952.
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Sheila A. Doggrell. (2019) Lessons that can be learnt from the failure of verubecestat in Alzheimer’s disease. Expert Opinion on Pharmacotherapy 20:17, pages 2095-2099.
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Juan F. González, Andrés R. Alcántara, Antonio L. Doadrio & Jose María Sánchez-Montero. (2019) Developments with multi-target drugs for Alzheimer’s disease: an overview of the current discovery approaches. Expert Opinion on Drug Discovery 14:9, pages 879-891.
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Yung-Chih Kuo & Rajendiran Rajesh. (2019) Challenges in the treatment of Alzheimer’s disease: recent progress and treatment strategies of pharmaceuticals targeting notable pathological factors. Expert Review of Neurotherapeutics 19:7, pages 623-652.
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