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Research Article

6-(N-benzoylamino)purine as a novel and potent inhibitor of xanthine oxidase: Inhibition mechanism and molecular modeling studies

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Pages 317-324 | Received 23 Nov 2004, Accepted 28 Feb 2005, Published online: 04 Oct 2008

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Ritu Ojha, Jagjeet Singh, Anu Ojha, Harbinder Singh, Sahil Sharma & Kunal Nepali. (2017) An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015). Expert Opinion on Therapeutic Patents 27:3, pages 311-345.
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Arlinda Bytyqi-Damoni, Hayriye Genç, Mustafa Zengin, Serap Beyaztas, Nahit Gençer & Oktay Arslan. (2012) In vitro effect of novel β-lactam compounds on xanthine oxidase enzyme activity. Artificial Cells, Blood Substitutes, and Biotechnology 40:6, pages 369-377.
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Raj Kumar, Darpan, Sahil Sharma & Rajveer Singh. (2011) Xanthine oxidase inhibitors: a patent survey. Expert Opinion on Therapeutic Patents 21:7, pages 1071-1108.
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Articles from other publishers (17)

Sucheta Singh, Sumit Tehlan & Prabhakar Kumar Verma. (2023) Pyrazole Scaffolds Having Promising Pharmacological Potential: A Review. Mini-Reviews in Medicinal Chemistry 23:22, pages 2142-2165.
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M.D. Santi, E. Bedoya Aguirre, M.F. Negro, M. Paulino Zunini, M.A. Peralta & M.G. Ortega. (2023) Prenylated flavonoids from Dalea genus as xanthine oxidase inhibitors: In vitro bioactivity evaluation and molecular docking studies. Results in Chemistry 6, pages 101115.
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Yazdan Maghsoud, Chao Dong & G. Andrés Cisneros. (2023) Investigation of the Inhibition Mechanism of Xanthine Oxidoreductase by Oxipurinol: A Computational Study. Journal of Chemical Information and Modeling 63:13, pages 4190-4206.
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Yazdan Maghsoud, Chao Dong & G. Andrés Cisneros. (2023) Computational Characterization of the Inhibition Mechanism of Xanthine Oxidoreductase by Topiroxostat. ACS Catalysis 13:9, pages 6023-6043.
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XinYing Zhu, Chao Yang, Lei Zhang & Jing Li. (2022) Identification of novel dual inhibitors targeting XOR and URAT1 via multiple virtual screening methods. Journal of Molecular Structure 1256, pages 132567.
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Oksana Muzychka, Olexandr Kobzar, Oleg Shablykin, Volodymyr Brovarets & Andriy Vovk. (2020) 5-Substituted N-(9H-purin-6-yl)-1,2-oxazole-3-carboxamides as xanthine oxidase inhibitors. Ukrainica Bioorganica Acta 15:1, pages 20-25.
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Giuseppe Luna, Anton V. Dolzhenko & Ricardo L. Mancera. (2019) Inhibitors of Xanthine Oxidase: Scaffold Diversity and Structure‐Based Drug Design. ChemMedChem 14:7, pages 714-743.
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Md Rahmat Ali, Suresh Kumar, Obaid Afzal, Nishtha Shalmali, Manju Sharma & Sandhya Bawa. (2016) Development of 2-(Substituted Benzylamino)-4-Methyl-1, 3-Thiazole-5-Carboxylic Acid Derivatives as Xanthine Oxidase Inhibitors and Free Radical Scavengers. Chemical Biology & Drug Design 87:4, pages 508-516.
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Shiwani Shukla, Dinesh Kumar, Ritu Ojha, Manish K. Gupta, Kunal Nepali & Preet M. S. Bedi. (2014) 4,6-Diaryl/heteroarylpyrimidin-2(1 H )-ones as a New Class of Xanthine Oxidase Inhibitors . Archiv der Pharmazie 347:7, pages 486-495.
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Rajni Dhiman, Sahil Sharma, Gagandip Singh, Kunal Nepali & Preet Mohinder Singh Bedi. (2013) Design and Synthesis of Aza-Flavones as a New Class of Xanthine Oxidase Inhibitors. Archiv der Pharmazie 346:1, pages 7-16.
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Kunal Nepali, Amit Agarwal, Sameer Sapra, Vineet Mittal, Raj Kumar, Uttam C. Banerjee, Manish K. Gupta, Naresh K. Satti, Om P. Suri & Kanaya L. Dhar. (2011) N-(1,3-Diaryl-3-oxopropyl)amides as a new template for xanthine oxidase inhibitors. Bioorganic & Medicinal Chemistry 19:18, pages 5569-5576.
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Kunal Nepali, Gurinderdeep Singh, Anil Turan, Amit Agarwal, Sameer Sapra, Raj Kumar, Uttam C. Banerjee, Prabhakar K. Verma, Naresh K. Satti, Manish K. Gupta, Om P. Suri & K.L. Dhar. (2011) A rational approach for the design and synthesis of 1-acetyl-3,5-diaryl-4,5-dihydro(1H)pyrazoles as a new class of potential non-purine xanthine oxidase inhibitors. Bioorganic & Medicinal Chemistry 19:6, pages 1950-1958.
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Sebastian Metz & Walter Thiel. (2009) A Combined QM/MM Study on the Reductive Half-Reaction of Xanthine Oxidase: Substrate Orientation and Mechanism. Journal of the American Chemical Society 131:41, pages 14885-14902.
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. 2009. Class 1 · Oxidoreductases. Class 1 · Oxidoreductases 729 756 .
Jung-Feng Hsieh, Shih-Hsiung Wu, Yu-Liang Yang, Kee-Fong Choong & Shui-Tein Chen. (2007) The screening and characterization of 6-aminopurine-based xanthine oxidase inhibitors. Bioorganic & Medicinal Chemistry 15:10, pages 3450-3456.
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Hemlata Tamta, Sukirti Kalra, Ramasamy Thilagavathi, Asit K. Chakraborti & Anup K. Mukhopadhyay. (2007) Nature and position of functional group on thiopurine substrates influence activity of xanthine oxidase — Enzymatic reaction pathways of 6-mercaptopurine and 2-mercaptopurine are different. Biochemistry (Moscow) 72:2, pages 170-177.
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Hemlata Tamta, Sukirti Kalra & Anup K. Mukhopadhyay. (2006) Biochemical characterization of some pyrazolopyrimidine-based inhibitors of xanthine oxidase. Biochemistry (Moscow) 71:S1, pages S49-S54.
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