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Refaie M Kassab, Sami A Al-Hussain, Nooran S Elleboudy, Amgad Albohy, Magdi EA Zaki, Khaled AM Abouzid & Zeinab A Muhammad. (2022) Tackling Microbial Resistance with Isatin-Decorated Thiazole Derivatives: Design, Synthesis, and in vitro Evaluation of Antimicrobial and Antibiofilm Activity. Drug Design, Development and Therapy 16, pages 2817-2832.
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Alaa A.-M. Abdel-Aziz, Adel S. El-Azab, Nawaf A. AlSaif, Ahmad J. Obaidullah, Abdulrahman M. Al-Obaid & Ibrahim A. Al-Suwaidan. (2021) Synthesis, potential antitumor activity, cell cycle analysis, and multitarget mechanisms of novel hydrazones incorporating a 4-methylsulfonylbenzene scaffold: a molecular docking study. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 1520-1538.
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Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Silvia Bua, Alessio Nocentini, Nawaf A. AlSaif, Mohammed M. Alanazi, Manal A. El-Gendy, Hany E. A. Ahmed & Claudiu T. Supuran. (2020) S-substituted 2-mercaptoquinazolin-4(3H)-one and 4-ethylbenzensulfonamides act as potent and selective human carbonic anhydrase IX and XII inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 733-743.
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Walaa M. El-Husseiny, Magda A.-A. El-Sayed, Adel S. El-Azab, Nawaf A. AlSaif, Mohammed M. Alanazi & Alaa A.-M. Abdel-Aziz. (2020) Synthesis, antitumor activity, and molecular docking study of 2-cyclopentyloxyanisole derivatives: mechanistic study of enzyme inhibition. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 744-758.
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Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Hany E. A. Ahmed, Sivia Bua, Alessio Nocentini, Nawaf A. AlSaif, Ahmad J. Obaidullah, Mohamed M. Hefnawy & Claudiu T. Supuran. (2020) Exploring structure-activity relationship of S-substituted 2-mercaptoquinazolin-4(3H)-one including 4-ethylbenzenesulfonamides as human carbonic anhydrase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 598-609.
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Chirag N. Patel & Moksha B. Narechania. (2018) Targeting epidermal growth factor receptors inhibition in non-small-cell lung cancer: a computational approach. Molecular Simulation 44:17, pages 1478-1488.
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Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Laila A. Abou-Zeid, Walaa M. El-Husseiny, Ahmad M. El_Morsy, Manal A. El-Gendy & Magda A.-A. El-Sayed. (2018) Synthesis, antitumour activities and molecular docking of thiocarboxylic acid ester-based NSAID scaffolds: COX-2 inhibition and mechanistic studies. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 989-998.
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Walaa M. El-Husseiny, Magda A.-A. El-Sayed, Naglaa I. Abdel-Aziz, Adel S. El-Azab, Esam R. Ahmed & Alaa A.-M. Abdel-Aziz. (2018) Synthesis, antitumour and antioxidant activities of novel α,β-unsaturated ketones and related heterocyclic analogues: EGFR inhibition and molecular modelling study. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 507-518.
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Articles from other publishers (32)
Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Silvia Bua, Alessio Nocentini, Ahmed H. Bakheit, Hamad M. Alkahtani, Mohamed M. Hefnawy & Claudiu T. Supuran. (2023) Design, synthesis, and carbonic anhydrase inhibition activities of Schiff bases incorporating benzenesulfonamide scaffold: Molecular docking application. Saudi Pharmaceutical Journal 31:12, pages 101866.
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Dina I.A. Othman, Abdelrahman Hamdi, Walaa M. Elhusseiny, Adel S. El-Azab, Ahmed H. Bakheit, Mohamed Hefnawy & Alaa A.-M. Abdel-Aziz. (2023) Synthesis of novel spirochromane incorporating Schiff's bases, potential antiproliferative activity, and dual EGFR/HER2 inhibition: Cell cycle analysis and in silico study. Saudi Pharmaceutical Journal 31:11, pages 101803.
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Atamjit Singh, Karanvir Singh, Aman Sharma, Sambhav Sharma, Kevin Batra, Kaustubh Joshi, Brahmjeet Singh, Kirandeep Kaur, Renu Chadha & Preet Mohinder Singh Bedi. (2023) Mechanistic insight and structure activity relationship of isatin-based derivatives in development of anti-breast cancer agents. Molecular and Cellular Biochemistry.
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Adel S. El-Azab, Hamad M. Alkahtani, Nawaf A. AlSaif, Ibrahim A. Al-Suwaidan, Ahmad J. Obaidullah, Mohammed M. Alanazi, Abdulrahman M. Al-Obaid, Mohamed H.M. Al-Agamy & Alaa A.-M. Abdel-Aziz. (2023) Synthesis, antiproliferative and enzymatic inhibition activities of quinazolines incorporating benzenesulfonamide: Cell cycle analysis and molecular modeling study. Journal of Molecular Structure 1278, pages 134928.
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Naman Jain, Tanvi Goel, Snehal Thakar, Madhav Jadhav & Deepali Bansode. (2023) An Explicative Review on the Progress of Quinazoline Scaffold as
Bioactive Agents in the Past Decade. Medicinal Chemistry 19:3, pages 211-245.
Crossref
Crossref
Weiqin Liu, Lihui Shao, Chengpeng Li, Yayu Zou, Haitao Long, Yan Li, Qiangsheng Ge, Zhenchao Wang & Guiping Ouyang. (2023) Synthesis and Antitumor Activity of 3-Hydrazone Quinazolinone Derivatives. Chinese Journal of Organic Chemistry 43:1, pages 214.
Crossref
Crossref
Hamad M. Alkahtani, Amer Alhaj Zen, Ahmad J. Obaidullah, Mohammed M. Alanazi, Abdulrahman A. Almehizia, Siddique Akber Ansari, Fadilah Sfouq Aleanizy, Fulwah Yahya Alqahtani, Rana M. Aldossari, Raghad Abdullah Algamdi, Lamees S. Al-Rasheed, Sami G. Abdel-Hamided, Alaa A.-M. Abdel-Aziz & Adel S. El-Azab. (2022) Synthesis, Cytotoxic Evaluation, and Structure-Activity Relationship of Substituted Quinazolinones as Cyclin-Dependent Kinase 9 Inhibitors. Molecules 28:1, pages 120.
Crossref
Crossref
Abdelrahman Hamdi, Walaa M. Elhusseiny, Dina I.A. Othman, Abdullah Haikal, Ahmed H. Bakheit, Adel S. El-Azab, Mohamed H.M. Al-Agamy & Alaa A.-M. Abdel-Aziz. (2022) Synthesis, antitumor, and apoptosis-inducing activities of novel 5-arylidenethiazolidine-2,4-dione derivatives: Histone deacetylases inhibitory activity and molecular docking study. European Journal of Medicinal Chemistry 244, pages 114827.
Crossref
Crossref
Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Hazem A. Ghabbour, Silvia Bua, Alessio Nocentini, Hamad M. Alkahtani, Nawaf A. Alsaif, Mohamed H. M. Al-Agamy & Claudiu T. Supuran. (2022) Carbonic Anhydrase Inhibition Activities of Schiff’s Bases Based on Quinazoline-Linked Benzenesulfonamide. Molecules 27:22, pages 7703.
Crossref
Crossref
Kashif Haider, Subham Das, Alex Joseph & M. Shahar Yar. (2022) An appraisal of anticancer activity with structure–activity relationship of quinazoline and quinazolinone analogues through EGFR and VEGFR inhibition: A review. Drug Development Research 83:4, pages 859-890.
Crossref
Crossref
Garima Chauhan, Dharam Pal Pathak, Faraat Ali, Pragya Dubey & Shaik Khasimbi. (2022)
In-vitro
Evaluation of Isatin Derivatives as Potent Anti-Breast Cancer Agents against
MCF-7, MDA MB 231, MDA-MB 435 and MDA-MB 468 Breast Cancers Cell Lines:
A Review
. Anti-Cancer Agents in Medicinal Chemistry 22:10, pages 1883-1896.
Crossref
Crossref
Abdelrahman Hamdi, Hamed W. El-Shafey, Dina I.A. Othman, Adel S. El-Azab, Nawaf A. AlSaif & Alaa A.-M. Abdel-Aziz. (2022) Design, synthesis, antitumor, and VEGFR-2 inhibition activities of novel 4-anilino-2-vinyl-quinazolines: Molecular modeling studies. Bioorganic Chemistry 122, pages 105710.
Crossref
Crossref
Raluca Pele, Gabriel Marc, Anca Stana, Ioana Ionuț, Cristina Nastasă, Brîndușa Tiperciuc, Ilioara Oniga, Adrian Pîrnău, Laurian Vlase & Ovidiu Oniga. (2022) Synthesis of New Phenolic Derivatives of Quinazolin-4(3H)-One as Potential Antioxidant Agents—In Vitro Evaluation and Quantum Studies. Molecules 27:8, pages 2599.
Crossref
Crossref
Daniel A. Gideon, Pushparaj Annadurai, Vijay Nirusimhan, Abhinav Parashar, Joel James & V. Violet Dhayabaran. 2022. Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Handbook of Oxidative Stress in Cancer: Therapeutic Aspects
923
947
.
Daniel A. Gideon, Pushparaj Annadurai, Vijay Nirusimhan, Abhinav Parashar, Joel James & V. Violet Dhayabaran. 2021. Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Handbook of Oxidative Stress in Cancer: Therapeutic Aspects
1
25
.
Ashraf N. Abdalla, Miriana Di Stefano, Giulio Poli, Tiziano Tuccinardi, Ammar Bader, Antonio Vassallo, Mohamed E. Abdallah, Mahmoud Zaki El-Readi, Bassem Refaat, Alanood S. Algarni, Rizwan Ahmad, Hamad M. Alkahtani, Alaa A.-M. Abdel-Aziz, Adel S. El-Azab & Aljawharah Alqathama. (2021) Co-Inhibition of P-gp and Hsp90 by an Isatin-Derived Compound Contributes to the Increase of the Chemosensitivity of MCF7/ADR-Resistant Cells to Doxorubicin. Molecules 27:1, pages 90.
Crossref
Crossref
Lvyin Zheng, Zhen Xie, Liuhuan Cai, Gongping Liu, Weijie Mei, Xiaoying Zou, Xiaoya Zhuo, Xiaolin Fan & Wei Guo. (2021) Green Catalyst‐ and Additive‐Free Three‐Component Deamination Cyclization Synthesis of 3‐Substituted‐4‐ oxo‐2‐quinazolinonyl Sulfides. ChemistrySelect 6:42, pages 11768-11774.
Crossref
Crossref
Rina Das, Dinesh K. Mehta & Meenakshi Dhanawat. (2021) Bestowal of Quinazoline Scaffold in Anticancer Drug Discovery. Anti-Cancer Agents in Medicinal Chemistry 21:11, pages 1350-1368.
Crossref
Crossref
Bhushan D. Varpe, Amol A. Kulkarni, Shailaja B. Jadhav, Anil S. Mali & Shravan Y. Jadhav. (2021) Isatin Hybrids and Their Pharmacological Investigations. Mini-Reviews in Medicinal Chemistry 21:10, pages 1182-1225.
Crossref
Crossref
Abdulmalik S. Altamimi, Adel S. El-Azab, Sami G. Abdelhamid, Mubarak A. Alamri, Ashraf H. Bayoumi, Safar M. Alqahtani, Alhumaidi B. Alabbas, Ali I. Altharawi, Manal A. Alossaimi & Menshawy A. Mohamed. (2021) Synthesis, Anticancer Screening of Some Novel Trimethoxy Quinazolines and VEGFR2, EGFR Tyrosine Kinase Inhibitors Assay; Molecular Docking Studies. Molecules 26:10, pages 2992.
Crossref
Crossref
Garima Chauhan, Dharam Pal Pathak, Faraat Ali, Rubina Bhutani, Garima Kapoor & Shaik Khasimbi. (2021) Advances in Synthesis, Derivatization and Bioactivity of Isatin: A Review. Current Organic Synthesis 18:1, pages 37-74.
Crossref
Crossref
Abdallah Turky, Ashraf H. Bayoumi, Adel Ghiaty, Adel S. El-Azab, Alaa A.-M. Abdel-Aziz & Hamada S. Abulkhair. (2020) Design, synthesis, and antitumor activity of novel compounds based on 1,2,4-triazolophthalazine scaffold: Apoptosis-inductive and PCAF-inhibitory effects. Bioorganic Chemistry 101, pages 104019.
Crossref
Crossref
Zhen Ding, Minfeng Zhou & Cheng Zeng. (2020) Recent advances in isatin hybrids as potential anticancer agents. Archiv der Pharmazie 353:3.
Crossref
Crossref
Ya‐Zhou Zhang, Hong‐Zhi Du, Hai‐Lin Liu, Qian‐Song He & Zhi Xu. (2020) Isatin dimers and their biological activities. Archiv der Pharmazie 353:3, pages 1900299.
Crossref
Crossref
Adel S. El-Azab, Hazem A. Ghabbour, Alaa A.-M. Abdel-Aziz & Hamad M. Alkahtani. (2020)
Crystal structure of 6-iodo-3-phenyl-2-propylquinazolin-4(3
H
)-one, C
17
H
15
IN
2
O
. Zeitschrift für Kristallographie - New Crystal Structures 235:2, pages 489-491.
Crossref
Crossref
Hamad M. Alkahtani, Ashraf N. Abdalla, Ahmad J. Obaidullah, Mohammed M. Alanazi, Abdulrahman A. Almehizia, Mashael G. Alanazi, Ahmed Y. Ahmed, Osama I. Alwassil, Hany W. Darwish, Alaa A.-M. Abdel-Aziz & Adel S. El-Azab. (2020) Synthesis, cytotoxic evaluation, and molecular docking studies of novel quinazoline derivatives with benzenesulfonamide and anilide tails: Dual inhibitors of EGFR/HER2. Bioorganic Chemistry 95, pages 103461.
Crossref
Crossref
Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Silvia Bua, Alessio Nocentini, Nawaf A. AlSaif, Abdulrahman A. Almehizia, Mohammed M. Alanazi, Mohamed M. Hefnawy & Claudiu T. Supuran. (2019) New anthranilic acid-incorporating N-benzenesulfonamidophthalimides as potent inhibitors of carbonic anhydrases I, II, IX, and XII: Synthesis, in vitro testing, and in silico assessment. European Journal of Medicinal Chemistry 181, pages 111573.
Crossref
Crossref
Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Silvia Bua, Alessio Nocentini, Mohammed M. Alanazi, Nawaf A. AlSaif, Ibrahim A. Al-Suwaidan, Mohamed M. Hefnawy & Claudiu T. Supuran. (2019) Synthesis and comparative carbonic anhydrase inhibition of new Schiff’s bases incorporating benzenesulfonamide, methanesulfonamide, and methylsulfonylbenzene scaffolds. Bioorganic Chemistry 92, pages 103225.
Crossref
Crossref
Yaling Zhang, Qiaoli Hou, Xiabing Li, Jiuling Zhu, Wei Wang, Baolin Li, Lijun Zhao & Haibin Xia. (2019) Enrichment of novel quinazoline derivatives with high antitumor activity in mitochondria tracked by its self-fluorescence. European Journal of Medicinal Chemistry 178, pages 417-432.
Crossref
Crossref
Hamad M. Alkahtani, Mohammed M. Alanazi, Fadilah Sfouq Aleanizy, Fulwah Yahya Alqahtani, Ali Alhoshani, Fawaz E. Alanazi, Abdulrahman A. Almehizia, Ashraf N. Abdalla, Mashael G. Alanazi, Adel S. El-Azab & Alaa A.-M. Abdel-Aziz. (2019) Synthesis, anticancer, apoptosis-inducing activities and EGFR and VEGFR2 assay mechanistic studies of 5,5-diphenylimidazolidine-2,4-dione derivatives: Molecular docking studies. Saudi Pharmaceutical Journal 27:5, pages 682-693.
Crossref
Crossref
Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Sivia Bua, Alessio Nocentini, Manal A. El-Gendy, Menshawy A. Mohamed, Taghreed Z. Shawer, Nawaf A. AlSaif & Claudiu T. Supuran. (2019) Synthesis of benzensulfonamides linked to quinazoline scaffolds as novel carbonic anhydrase inhibitors. Bioorganic Chemistry 87, pages 78-90.
Crossref
Crossref
Varun Varun, Sonam Sonam & Rita Kakkar. (2019) Isatin and its derivatives: a survey of recent syntheses, reactions, and applications. MedChemComm 10:3, pages 351-368.
Crossref
Crossref