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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 33, 2018 - Issue 1
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Research Paper

Synthesis, antitumour activities and molecular docking of thiocarboxylic acid ester-based NSAID scaffolds: COX-2 inhibition and mechanistic studies

Adel S. El-AzabDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; ;Department of Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt; Correspondence[email protected] [email protected]
ORCID Iconhttp://orcid.org/0000-0001-7197-1515
ORCID Icon,
Alaa A.-M. Abdel-AzizDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; ;Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt; ORCID Iconhttp://orcid.org/0000-0002-3362-9337
ORCID Icon,
Laila A. Abou-ZeidDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt;
,
Walaa M. El-HusseinyDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt;
,
Ahmad M. El_MorsyDepartment of Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt;
,
Manal A. El-GendyDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia;
&
Magda A.-A. El-SayedDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt; ;Department of Pharmaceutical Chemistry, Faculty of pharmacy, Horus university, New Damietta, EgyptORCID Iconhttp://orcid.org/0000-0001-9599-9248
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Pages 989-998 | Received 26 Mar 2018, Accepted 07 May 2018, Published online: 28 May 2018

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Alaa A.-M. Abdel-Aziz, Adel S. El-Azab, Nawaf A. AlSaif, Ahmad J. Obaidullah, Abdulrahman M. Al-Obaid & Ibrahim A. Al-Suwaidan. (2021) Synthesis, potential antitumor activity, cell cycle analysis, and multitarget mechanisms of novel hydrazones incorporating a 4-methylsulfonylbenzene scaffold: a molecular docking study. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 1520-1538.
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Walaa M. El-Husseiny, Magda A.-A. El-Sayed, Adel S. El-Azab, Nawaf A. AlSaif, Mohammed M. Alanazi & Alaa A.-M. Abdel-Aziz. (2020) Synthesis, antitumor activity, and molecular docking study of 2-cyclopentyloxyanisole derivatives: mechanistic study of enzyme inhibition. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 744-758.
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Alaa A.-M. Abdel-Aziz, Adel S. El-Azab, Nawaf A. AlSaif, Mohammed M. Alanazi, Manal A. El-Gendy, Ahmad J. Obaidullah, Hamad M. Alkahtani, Abdulrahman A. Almehizia & Ibrahim A. Al-Suwaidan. (2020) Synthesis, anti-inflammatory, cytotoxic, and COX-1/2 inhibitory activities of cyclic imides bearing 3-benzenesulfonamide, oxime, and β-phenylalanine scaffolds: a molecular docking study. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 610-621.
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Adel S. El-Azab, Hamad M. Alkahtani, Nawaf A. AlSaif, Ibrahim A. Al-Suwaidan, Ahmad J. Obaidullah, Mohammed M. Alanazi, Abdulrahman M. Al-Obaid, Mohamed H.M. Al-Agamy & Alaa A.-M. Abdel-Aziz. (2023) Synthesis, antiproliferative and enzymatic inhibition activities of quinazolines incorporating benzenesulfonamide: Cell cycle analysis and molecular modeling study. Journal of Molecular Structure 1278, pages 134928.
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