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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 34, 2019 - Issue 1
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Research Paper

Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold

Giulia RotondiDipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, Rome, Italy;
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Paolo GuglielmiDipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, Rome, Italy; Correspondence[email protected]
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Simone CarradoriDepartment of Pharmacy, “G. D’Annunzio”, University of Chieti-Pescara, Chieti, Italy; ORCID Iconhttp://orcid.org/0000-0002-8698-9440
ORCID Icon,
Daniela SecciDipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, Rome, Italy;
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Celeste De MonteDipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, Rome, Italy;
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Barbara De FilippisDepartment of Pharmacy, “G. D’Annunzio”, University of Chieti-Pescara, Chieti, Italy;
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Cristina MaccalliniDepartment of Pharmacy, “G. D’Annunzio”, University of Chieti-Pescara, Chieti, Italy;
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Rosa AmorosoDepartment of Pharmacy, “G. D’Annunzio”, University of Chieti-Pescara, Chieti, Italy;
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Roberto CirilliCentro Nazionale per il Controllo e la Valutazione dei Farmaci, Istituto Superiore di Sanità, Rome, Italy;
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Atilla AkdemirComputer-aided Drug Discovery Laboratory, Faculty of Pharmacy, Department of Pharmacology, Bezmialem Vakif University, Fatih, Istanbul, Turkey;
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Andrea AngeliNeurofarba Department, Section of Pharmaceutical and Nutraceutical Sciences, Università degli Studi di Firenze, Sesto Fiorentino (Florence), ItalyORCID Iconhttp://orcid.org/0000-0002-1470-7192
ORCID Icon &
Claudiu T. SupuranNeurofarba Department, Section of Pharmaceutical and Nutraceutical Sciences, Università degli Studi di Firenze, Sesto Fiorentino (Florence), ItalyCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-4262-0323
ORCID Icon show all
Pages 1400-1413 | Received 05 Jul 2019, Accepted 26 Jul 2019, Published online: 11 Aug 2019

Citations (22)

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Mattia Mori & Claudiu T. Supuran. (2022) Acipimox inhibits human carbonic anhydrases. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 672-679.
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Gasem Mohammad Abu-Taweel, Munjed M. Ibrahim, Sikandar Khan, Hamed M. Al-Saidi, Meshal Alshamrani, Fahad A. Alhumaydhi & Salman S. Alharthi. (2022) Medicinal Importance and Chemosensing Applications of Pyridine Derivatives: A Review. Critical Reviews in Analytical Chemistry 0:0, pages 1-18.
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Chandra Bhushan Mishra, Raj Kumar Mongre, Amresh Prakash, Raok Jeon, Claudiu T. Supuran & Myeong-Sok Lee. (2021) Anti-breast cancer action of carbonic anhydrase IX inhibitor 4-[4-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-benzylidene-hydrazinocarbonyl]-benzenesulfonamide (BSM-0004): in vitro and in vivo studies. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 954-963.
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Claudiu T. Supuran. (2020) Exploring the multiple binding modes of inhibitors to carbonic anhydrases for novel drug discovery. Expert Opinion on Drug Discovery 15:6, pages 671-686.
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Paolo Guglielmi, Giulia Rotondi, Daniela Secci, Andrea Angeli, Paola Chimenti, Alessio Nocentini, Alessandro Bonardi, Paola Gratteri, Simone Carradori & Claudiu T. Supuran. (2020) Novel insights on saccharin- and acesulfame-based carbonic anhydrase inhibitors: design, synthesis, modelling investigations and biological activity evaluation. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 1891-1905.
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Alessio Nocentini, Sonia Del Prete, Margaret D. Mastrolorenzo, William A. Donald, Clemente Capasso & Claudiu T. Supuran. (2020) Activation studies of the β-carbonic anhydrases from Escherichia coli with amino acids and amines. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 1379-1386.
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Mehmet Oguz, Erbay Kalay, Suleyman Akocak, Alessio Nocentini, Nebih Lolak, Mehmet Boga, Mustafa Yilmaz & Claudiu T. Supuran. (2020) Synthesis of calix[4]azacrown substituted sulphonamides with antioxidant, acetylcholinesterase, butyrylcholinesterase, tyrosinase and carbonic anhydrase inhibitory action. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 1215-1223.
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Rakia Abd Alhameed, Emanuela Berrino, Zainab Almarhoon, Ayman El-Faham & Claudiu T. Supuran. (2020) A class of carbonic anhydrase IX/XII – selective carboxylate inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 549-554.
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