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Expert Review of Vaccines Volume 19, 2020 - Issue 6
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Review

Improving protein glycan coupling technology (PGCT) for glycoconjugate vaccine production

Jennifer Mhairi DowDepartment of Infection Biology, London School of Hygiene & Tropical Medicine, London, UKView further author information
,
Marta MauriDepartment of Infection Biology, London School of Hygiene & Tropical Medicine, London, UKORCID Iconhttps://orcid.org/0000-0003-0098-3900View further author information
ORCID Icon,
Timothy Alexander ScottDepartment of Infection Biology, London School of Hygiene & Tropical Medicine, London, UKView further author information
&
Brendan William WrenDepartment of Infection Biology, London School of Hygiene & Tropical Medicine, London, UKCorrespondence[email protected]
View further author information
Pages 507-527 | Received 06 Dec 2019, Accepted 20 May 2020, Published online: 05 Jul 2020

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Jing Huang, Yan Guo, Shujuan Yu, Dongshu Wang, Shulei Li, Jun Wu, Peng Sun, Li Zhu, Hengliang Wang & Chao Pan. (2023) One-step preparation of a self-assembled bioconjugate nanovaccine against Brucella. Virulence 14:1.
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Charlotte Sorieul, Marta Dolce, Maria Rosaria Romano, Jeroen Codée & Roberto Adamo. (2023) Glycoconjugate vaccines against antimicrobial resistant pathogens. Expert Review of Vaccines 22:1, pages 1055-1078.
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Wenhui Xue, Tingting Li, Ying Gu, Shaowei Li & Ningshao Xia. (2023) Molecular engineering tools for the development of vaccines against infectious diseases: current status and future directions. Expert Review of Vaccines 22:1, pages 563-578.
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Henderson Zhu, Christine S. Rollier & Andrew J. Pollard. (2021) Recent advances in lipopolysaccharide-based glycoconjugate vaccines. Expert Review of Vaccines 20:12, pages 1515-1538.
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Articles from other publishers (14)

Sophia W. Hulbert, Primit Desai, Michael C. Jewett, Matthew P. DeLisa & Asher J. Williams. (2023) Glycovaccinology: The design and engineering of carbohydrate-based vaccine components. Biotechnology Advances 68, pages 108234.
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Sherif Abouelhadid, Elizabeth R. Atkins, Emily J. Kay, Ian J. Passmore, Simon J. North, Burhan Lehri, Paul Hitchen, Eirik Bakke, Mohammed Rahman, Janine T. Bossé, Yanwen Li, Vanessa S. Terra, Paul R. Langford, Anne Dell, Brendan W. Wren & Jon Cuccui. (2023) Development of a novel glycoengineering platform for the rapid production of conjugate vaccines. Microbial Cell Factories 22:1.
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Yan Liu, Chao Pan, Kangfeng Wang, Yan Guo, YanGe Sun, Xiang Li, Peng Sun, Jun Wu, Hengliang Wang & Li Zhu. (2023) Preparation of a Klebsiella pneumoniae conjugate nanovaccine using glycol-engineered Escherichia coli. Microbial Cell Factories 22:1.
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Jing Huang, Yufei Wang, Kangfeng Wang, Shulei Li, Peng Sun, Yan Guo, Jiankai Liu, Ruifu Yang, Ming Zeng, Chao Pan, Hengliang Wang & Li Zhu. (2023) Biosynthesis and Immunological Evaluation of a Dual-Antigen Nanoconjugate Vaccine against Brucella melitensis. Engineering.
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Tyler D. Moeller, Shivem B. Shah, Kristine Lai, Natalia Lopez-Barbosa, Primit Desai, Weiyao Wang, Zhe Zhong, David Redmond, Ankur Singh & Matthew P. DeLisa. (2023) Profiling Germinal Center-like B Cell Responses to Conjugate Vaccines Using Synthetic Immune Organoids. ACS Central Science 9:4, pages 787-804.
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Keira Burns, Helge C. Dorfmueller, Brendan W. Wren, Fatme Mawas & Helen A. Shaw. (2023) Progress towards a glycoconjugate vaccine against Group A Streptococcus. npj Vaccines 8:1.
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Typhaine Violo, Annie Lambert, Aline Pillot, Mathieu Fanuel, Jessica Mac‐Béar, Cédric Broussard, Cyrille Grandjean & Emilie Camberlein. (2023) Site‐Selective Unnatural Amino Acid Incorporation at Single or Multiple Positions to Control Sugar‐Protein Connectivity in Glycoconjugate Vaccine Candidates. Chemistry – A European Journal 29:15.
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Shulei Li, Jing Huang, Kangfeng Wang, Yan Liu, Yan Guo, Xiang Li, Jun Wu, Peng Sun, Yufei Wang, Li Zhu & Hengliang Wang. (2023) A bioconjugate vaccine against Brucella abortus produced by engineered Escherichia coli. Frontiers in Bioengineering and Biotechnology 11.
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Emily J. Kay, Marta Mauri, Sam J. Willcocks, Timothy A. Scott, Jon Cuccui & Brendan W. Wren. (2022) Engineering a suite of E. coli strains for enhanced expression of bacterial polysaccharides and glycoconjugate vaccines. Microbial Cell Factories 21:1.
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Vanessa S. Terra, Marta Mauri, Thippeswamy H. Sannasiddappa, Alexander A. Smith, Mark P. Stevens, Andrew J. Grant, Brendan W. Wren & Jon Cuccui. (2022) PglB function and glycosylation efficiency is temperature dependent when the pgl locus is integrated in the Escherichia coli chromosome. Microbial Cell Factories 21:1.
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Simone Nicolardi, Renzo Danuser, Viktoria Dotz, Elena Domínguez-Vega, Ali Al Kaabi, Michel Beurret, Chakkumkal Anish & Manfred Wuhrer. (2022) Glycan and Protein Analysis of Glycoengineered Bacterial E. coli Vaccines by MALDI-in-Source Decay FT-ICR Mass Spectrometry . Analytical Chemistry 94:12, pages 4979-4987.
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Jasmin J. Samaras, Marta Mauri, Emily J. Kay, Brendan W. Wren & Martina Micheletti. (2021) Development of an automated platform for the optimal production of glycoconjugate vaccines expressed in Escherichia coli. Microbial Cell Factories 20:1.
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Marta Mauri, Thippeswamy H. Sannasiddappa, Prerna Vohra, Ricardo Corona-Torres, Alexander A. Smith, Cosmin Chintoan-Uta, Abi Bremner, Vanessa S. Terra, Sherif Abouelhadid, Mark P. Stevens, Andrew J. Grant, Jon Cuccui & Brendan W. Wren. (2021) Multivalent poultry vaccine development using Protein Glycan Coupling Technology. Microbial Cell Factories 20:1.
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Cory J Knoot, Lloyd S Robinson & Christian M Harding. (2021) A minimal sequon sufficient for O -linked glycosylation by the versatile oligosaccharyltransferase PglS . Glycobiology.
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