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Original Articles

Ochratoxin a: Its Cancer Risk and Potential for Exposure

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Pages 265-296 | Published online: 24 Feb 2007

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (26)

Amal Saad-Hussein, Kawther M. Soliman & Gehan Moubarz. (2022) 18S rRNA gene sequencing for environmental aflatoxigenic fungi and risk of hepatic carcinoma among exposed workers. Journal of Environmental Science and Health, Part A 57:3, pages 174-182.
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Fereshteh Mehri, Maryam Esfahani, Ali Heshmati, Ensiyeh Jenabi & Salman Khazaei. (2022) The prevalence of ochratoxin A in dried grapes and grape-derived products: a systematic review and meta-analysis. Toxin Reviews 41:1, pages 347-356.
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Bruna Leonel Gonçalves, Carolina Fernanda Sengling Cebin Coppa, Diane Valganon de Neeff, Carlos Humberto Corassin & Carlos Augusto Fernandes Oliveira. (2019) Mycotoxins in fruits and fruit-based products: occurrence and methods for decontamination. Toxin Reviews 38:4, pages 263-272.
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Amany M. Diab, Salem R.M.El-Keredy M.S. Abeer, Gehan I.E. Ali & Nagwan El-Habashi. (2018) Experimental ochratoxicosis A in Nile tilapia and its amelioration by some feed additives. International Journal of Veterinary Science and Medicine 6:2, pages 149-158.
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Sibel Ozcakmak & Osman Gul. (2017) Inhibition kinetics of Penicillium verrucosum using different essential oils and application of predictive inactivation models. International Journal of Food Properties 20:sup1, pages S684-S692.
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Carla Viegas, Cátia Pacífico, Tiago Faria, Ana Cebola de Oliveira, Liliana Aranha Caetano, Elisabete Carolino, Anita Quintal Gomes & Susana Viegas. (2017) Fungal contamination in green coffee beans samples: A public health concern. Journal of Toxicology and Environmental Health, Part A 80:13-15, pages 719-728.
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Hervé Robert, Delphine Payros, Philippe Pinton, Vassilia Théodorou, Muriel Mercier-Bonin & Isabelle P. Oswald. (2017) Impact of mycotoxins on the intestine: are mucus and microbiota new targets?. Journal of Toxicology and Environmental Health, Part B 20:5, pages 249-275.
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Kra Brou Didier Kedjebo, Tagro Simplice Guehi, Brou Kouakou, Noël Durand, Philippe Aguilar, Angélique Fontana & Didier Montet. (2016) Effect of post-harvest treatments on the occurrence of ochratoxin A in raw cocoa beans. Food Additives & Contaminants: Part A 33:1, pages 157-166.
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Muhammad Asif Asghar, Aftab Ahmed & Javed Iqbal. (2016) Aflatoxins and ochratoxin A in export quality raisins collected from different areas of Pakistan. Food Additives & Contaminants: Part B 9:1, pages 51-58.
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Jun Liu, Steve O. Simmons & Ruoting Pei. (2014) Regulation of IL-8 Promoter Activity by Verrucarin A in Human Monocytic THP-1 Cells. Journal of Toxicology and Environmental Health, Part A 77:19, pages 1125-1140.
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Pronobesh Chatopadhyay, Banlumlang Tariang, Amit Agnihotri & Vijay Veer. (2014) Synergism of ochratoxin B and calcium-channel antagonist verapamil caused mitochondrial dysfunction. Toxicology Mechanisms and Methods 24:6, pages 428-432.
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Ricardo Assunção, Mariana Ferreira, Carla Martins, Irene Diaz, Beatriz Padilla, Didier Dupont, Mauro Bragança & Paula Alvito. (2014) Applicability of In Vitro Methods to Study Patulin Bioaccessibility and Its Effects on Intestinal Membrane Integrity. Journal of Toxicology and Environmental Health, Part A 77:14-16, pages 983-992.
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C. Viegas, R. Dias, A. Quintal Gomes, M. Meneses, R. Sabino & S. Viegas. (2014) Aspergillus flavus Contamination in Two Portuguese Wastewater Treatment Plants. Journal of Toxicology and Environmental Health, Part A 77:14-16, pages 796-805.
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Frantisek Malir, Vladimir Ostry & Eva Novotna. (2013) Toxicity of the mycotoxin ochratoxin A in the light of recent data. Toxin Reviews 32:2, pages 19-33.
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C. Viegas, E. Carolino, R. Sabino, S. Viegas & C. Veríssimo. (2013) Fungal Contamination in Swine: A Potential Occupational Health Threat. Journal of Toxicology and Environmental Health, Part A 76:4-5, pages 272-280.
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Muhammad Aslam, S. Abidul Hassan Rivzi, Anwer Ejaz Beg, Meinolf Blaszkewicz, Klaus Golka & Gisela H. Degen. (2012) Analysis of Ochratoxin a Blood Levels in Bladder Cancer Cases and Healthy Persons from Pakistan. Journal of Toxicology and Environmental Health, Part A 75:19-20, pages 1176-1184.
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Pierluigi Plastina, Alessia Fazio, Mohamed Attya, Giovanni Sindona & Bartolo Gabriele. (2012) Synthesis of analogues of ochratoxin A. Natural Product Research 26:19, pages 1799-1805.
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C. Viegas, E. Carolino, J. Malta-Vacas, R. Sabino, S. Viegas & C. Veríssimo. (2012) Fungal Contamination of Poultry Litter: A Public Health Problem. Journal of Toxicology and Environmental Health, Part A 75:22-23, pages 1341-1350.
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Imen Ayed-Boussema, Jean Marc Pascussi, Chiraz Zaied, Patrick Maurel, Hassen Bacha & Wafa Hassen. (2012) Ochratoxin A induces CYP3A4, 2B6, 3A5, 2C9, 1A1, and CYP1A2 gene expression in primary cultured human hepatocytes: a possible activation of nuclear receptors. Drug and Chemical Toxicology 35:1, pages 71-80.
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Ruoting Pei & Claudia K. Gunsch. (2011) Cytotoxic and proinflammatory response of RAW 264.7 cells to differentially fractionated fungal fragments. Toxicological & Environmental Chemistry 93:7, pages 1386-1398.
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J. Bansal, P. Pantazopoulos, J. Tam, P. Cavlovic, K. Kwong, A.-M. Turcotte, B.P.-Y. Lau & P.M. Scott. (2011) Surveys of rice sold in Canada for aflatoxins, ochratoxin A and fumonisins. Food Additives & Contaminants: Part A 28:6, pages 767-774.
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A.-M. Turcotte & P.M. Scott. (2011) Ochratoxin A in cocoa and chocolate sampled in Canada. Food Additives & Contaminants: Part A 28:6, pages 762-766.
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J. Tam, P. Pantazopoulos, P.M. Scott, J. Moisey, R.W. Dabeka & I.D.K. Richard. (2011) Application of isotope dilution mass spectrometry: determination of ochratoxin A in the Canadian Total Diet Study. Food Additives & Contaminants: Part A 28:6, pages 754-761.
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S.C. Duarte, C.M. Lino & A. Pena. (2010) Mycotoxin food and feed regulation and the specific case of ochratoxin A: a review of the worldwide status. Food Additives & Contaminants: Part A 27:10, pages 1440-1450.
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Stela Živčić-Ćosić, Mirjana Gržetić, Maksim Valenčić, Romano Oguić, Anton Maričić, Gordana Đorđević, Sanja Balen, Lidija Orlić, Sanjin Rački & Željko Fučkar. (2007) Urothelial Cancer in Patients with Endemic Balkan Nephropathy (EN) after Renal Transplantation. Renal Failure 29:7, pages 861-865.
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Gabriele Jedlitschky, Ulrich Hoffmann & Heyo K Kroemer. (2006) Structure and function of the MRP2 (ABCC2) protein and its role in drug disposition. Expert Opinion on Drug Metabolism & Toxicology 2:3, pages 351-366.
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Kyu Hyun Rhee, Seon Ah Yang, Min Cheol Pyo, Jae-Min Lim & Kwang-Won Lee. (2023) MiR-155-5p Elevated by Ochratoxin A Induces Intestinal Fibrosis and Epithelial-to-Mesenchymal Transition through TGF-β Regulated Signaling Pathway In Vitro and In Vivo. Toxins 15:7, pages 473.
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Szilamér Ferenczi, Mátyás Cserháti, Csilla Krifaton, Sándor Szoboszlay, József Kukolya, Zsuzsanna Szőke, Balázs Kőszegi, Mihály Albert, Teréz Barna, Miklós Mézes, Krisztina J. Kovács & Balázs Kriszt. (2014) A New Ochratoxin A Biodegradation Strategy Using Cupriavidus basilensis Őr16 Strain. PLoS ONE 9:10, pages e109817.
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Jinfeng Cui, Jing Liu, Sha Wu, Yuan Wang, Haitao Shen, Lingxiao Xing, Junling Wang, Xia Yan & Xianghong Zhang. (2013) Oxidative DNA damage is involved in ochratoxin A-induced G2 arrest through ataxia telangiectasia-mutated (ATM) pathways in human gastric epithelium GES-1 cells in vitro. Archives of Toxicology 87:10, pages 1829-1840.
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Vladimir Ostry, Frantisek Malir & Jiri Ruprich. (2013) Producers and Important Dietary Sources of Ochratoxin A and Citrinin. Toxins 5:9, pages 1574-1586.
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D. Pattono, A. Grosso, P.P. Stocco, M. Pazzi & G. Zeppa. (2013) Survey of the presence of patulin and ochratoxin A in traditional semi-hard cheeses. Food Control 33:1, pages 54-57.
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Anne-Marie Turcotte, Peter M. Scott & Brett Tague. (2013) Analysis of cocoa products for ochratoxin A and aflatoxins. Mycotoxin Research 29:3, pages 193-201.
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Khadije Rahimi, Ali Mohamadi Sani & Eisa Gholampour Azizi. (2013) Effect of thermal treatment on ochratoxin content of chickpea. Nutrition & Food Science 43:3, pages 285-290.
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Janette Hope. (2013) A Review of the Mechanism of Injury and Treatment Approaches for Illness Resulting from Exposure to Water-Damaged Buildings, Mold, and Mycotoxins. The Scientific World Journal 2013, pages 1-20.
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Arthur P. Grollman. (2013) Aristolochic acid nephropathy: Harbinger of a global iatrogenic disease. Environmental and Molecular Mutagenesis 54:1, pages 1-7.
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S.S. Palabiyik, P. Erkekoglu, N.D. Zeybek, M. Kızılgun, G. Sahin & B. Kocer Giray. (2012) Ochratoxin A causes oxidative stress and cell death in rat liver. World Mycotoxin Journal 5:4, pages 377-384.
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Sofia C. Duarte, Celeste M. Lino & Angelina Pena. (2012) Food safety implications of ochratoxin A in animal-derived food products. The Veterinary Journal 192:3, pages 286-292.
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Jing Liu, Yuan Wang, Jinfeng Cui, Lingxiao Xing, Haitao Shen, Sha Wu, Hongguang Lian, Junling Wang, Xia Yan & Xianghong Zhang. (2012) Ochratoxin A induces oxidative DNA damage and G1 phase arrest in human peripheral blood mononuclear cells in vitro. Toxicology Letters 211:2, pages 164-171.
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Valeria Sorrenti, Claudia Di Giacomo, Rosaria Acquaviva, Matteo Bognanno, Ester Grilli, Nicolantonio D’Orazio & Fabio Galvano. (2012) Dimethylarginine Dimethylaminohydrolase/Nitric Oxide Synthase Pathway in Liver and Kidney: Protective Effect of Cyanidin 3-O-β-D-Glucoside on Ochratoxin-A Toxicity. Toxins 4:5, pages 353-363.
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Tien Ping Lee, Bahruddin Saad, Eng Poh Ng & Baharuddin Salleh. (2012) Zeolite Linde Type L as micro-solid phase extraction sorbent for the high performance liquid chromatography determination of ochratoxin A in coffee and cereal. Journal of Chromatography A 1237, pages 46-54.
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