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Original

Oncothermia Treatment of Cancer: From the Laboratory to Clinic

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Pages 148-165 | Published online: 21 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (10)

Sunghyun Kim, Jun Hyeok Lee, Jihye Cha & Sei Hwan You. (2021) Beneficial effects of modulated electro-hyperthermia during neoadjuvant treatment for locally advanced rectal cancer. International Journal of Hyperthermia 38:1, pages 144-151.
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Yuk-Wah Tsang, Kwan-Hwa Chi, Cheng-Chung Huang, Mau-Shin Chi, Hsin-Chien Chiang, Kai-Lin Yang, Wen-Tyng Li & Yu-Shan Wang. (2019) Modulated electro-hyperthermia-enhanced liposomal drug uptake by cancer cells. International Journal of Nanomedicine 14, pages 1269-1279.
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Wookyeom Yang, Gwan Hee Han, Ha-Yeon Shin, Eun-Ju Lee, Hanbyoul Cho, Doo Byung Chay & Jae-Hoon Kim. (2019) Combined treatment with modulated electro-hyperthermia and an autophagy inhibitor effectively inhibit ovarian and cervical cancer growth. International Journal of Hyperthermia 36:1, pages 9-20.
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Sun-Young Lee, Jong-Hun Kim, Yeon-Hee Han & Dong-Hyu Cho. (2018) The effect of modulated electro-hyperthermia on temperature and blood flow in human cervical carcinoma. International Journal of Hyperthermia 34:7, pages 953-960.
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Wonwoo Kim, Mi-Sook Kim, Hee-jong Kim, Eunjin Lee, Jae-hoon Jeong, Inhwan Park, Youn Kyoung Jeong & Won Il Jang. (2018) Role of HIF-1α in response of tumors to a combination of hyperthermia and radiation in vivo. International Journal of Hyperthermia 34:3, pages 276-283.
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Tae-Won Jeon, Heebum Yang, Chang Geol Lee, Sang Taek Oh, Daekwan Seo, In Hye Baik, Eun Hye Lee, Ina Yun, Kyung Ran Park & Yun-Han Lee. (2016) Electro-hyperthermia up-regulates tumour suppressor Septin 4 to induce apoptotic cell death in hepatocellular carcinoma. International Journal of Hyperthermia 32:6, pages 648-656.
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Jihye Cha, Tae-Won Jeon, Chang Geol Lee, Sang Taek Oh, Hee-Beom Yang, Kyung-Ju Choi, Daekwan Seo, Ina Yun, In Hye Baik, Kyung Ran Park, Young Nyun Park & Yun-Han Lee. (2015) Electro-hyperthermia inhibits glioma tumorigenicity through the induction of E2F1-mediated apoptosis. International Journal of Hyperthermia 31:7, pages 784-792.
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Alberto Foletti, Settimio Grimaldi, Antonella Lisi, Mario Ledda & Abraham R. Liboff. (2013) Bioelectromagnetic medicine: The role of resonance signaling. Electromagnetic Biology and Medicine 32:4, pages 484-499.
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Dewei Jia & Jing Liu. (2010) Current devices for high-performance whole-body hyperthermia therapy. Expert Review of Medical Devices 7:3, pages 407-423.
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Articles from other publishers (41)

Jia-Liang Liu, Ming Yang, Jun-Ge Bai, Zheng Liu & Xi-Shan Wang. (2023) “Cold” colorectal cancer faces a bottleneck in immunotherapy. World Journal of Gastrointestinal Oncology 15:2, pages 240-250.
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Agata Czarnywojtek, Magdalena Borowska, Kamil Dyrka, Stefaan Van Gool, Nadia Sawicka-Gutaj, Jakub Moskal, Jeremi Kościński, Patryk Graczyk, Tomasz Hałas, Agnieszka Marta Lewandowska, Rafał Czepczyński & Marek Ruchała. (2023) Glioblastoma Multiforme: The Latest Diagnostics and Treatment Techniques. Pharmacology 108:5, pages 423-431.
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Marjolein I. Priester, Sergio Curto, Gerard C. van Rhoon & Timo L. M. ten Hagen. (2021) External Basic Hyperthermia Devices for Preclinical Studies in Small Animals. Cancers 13:18, pages 4628.
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Mbuotidem Jeremiah Thomas, Enikő Major, Anett Benedek, Ildikó Horváth, Domokos Máthé, Ralf Bergmann, Attila Marcell Szász, Tibor Krenács & Zoltán Benyó. (2020) Suppression of Metastatic Melanoma Growth in Lung by Modulated Electro-Hyperthermia Monitored by a Minimally Invasive Heat Stress Testing Approach in Mice. Cancers 12:12, pages 3872.
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I-Ming Kuo, Jih-Jong Lee, Yu-Shan Wang, Hsin-Chien Chiang, Cheng-Chung Huang, Pei-Jong Hsieh, Winston Han, Chiao-Hsu Ke, Albert T. C. Liao & Chen-Si Lin. (2020) Potential enhancement of host immunity and anti-tumor efficacy of nanoscale curcumin and resveratrol in colorectal cancers by modulated electro- hyperthermia. BMC Cancer 20:1.
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Huda F. Alshaibi, Bashayr Al-shehri, Basmah Hassan, Raghad Al-zahrani & Taghreed Assiss. (2020) Modulated Electrohyperthermia: A New Hope for Cancer Patients. BioMed Research International 2020, pages 1-13.
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K. D. Kazarinov, V. A. Shchelkonogov, O. A. Baranova, A. V. Chekanov, E. U. Solovieva & A. I. Fedin. (2021) The Effect of Microwave Radiation on Cell Sensitivity to Monohydric Alcohols in Platelet-Rich Plasma. Biophysics 65:6, pages 942-947.
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Tibor Krenacs, Nora Meggyeshazi, Gertrud Forika, Eva Kiss, Peter Hamar, Tamas Szekely & Tamas Vancsik. (2020) Modulated Electro-Hyperthermia-Induced Tumor Damage Mechanisms Revealed in Cancer Models. International Journal of Molecular Sciences 21:17, pages 6270.
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Gertrud Forika, Andrea Balogh, Tamas Vancsik, Attila Zalatnai, Gabor Petovari, Zoltan Benyo & Tibor Krenacs. (2020) Modulated Electro-Hyperthermia Resolves Radioresistance of Panc1 Pancreas Adenocarcinoma and Promotes DNA Damage and Apoptosis In Vitro. International Journal of Molecular Sciences 21:14, pages 5100.
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M.M. Paulides, H. Dobsicek Trefna, S. Curto & D.B. Rodrigues. (2020) Recent technological advancements in radiofrequency- andmicrowave-mediated hyperthermia for enhancing drug delivery. Advanced Drug Delivery Reviews 163-164, pages 3-18.
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Attila M. Szasz, Carrie Anne Minnaar, Gyongyver Szentmártoni, Gyula P. Szigeti & Magdolna Dank. (2019) Review of the Clinical Evidences of Modulated Electro-Hyperthermia (mEHT) Method: An Update for the Practicing Oncologist. Frontiers in Oncology 9.
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Heon Jong Yoo, Myong Cheol Lim, Sang-Soo Seo, Sokbom Kang, Jungnam Joo & Sang-Yoon Park. (2019) Phase I/II clinical trial of modulated electro-hyperthermia treatment in patients with relapsed, refractory or progressive heavily treated ovarian cancer. Japanese Journal of Clinical Oncology 49:9, pages 832-838.
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Balázs Besztercei, Tamás Vancsik, Anett Benedek, Enikő Major, Mbuotidem J. Thomas, Csaba A. Schvarcz, Tibor Krenács, Zoltán Benyó & Andrea Balogh. (2019) Stress-Induced, p53-Mediated Tumor Growth Inhibition of Melanoma by Modulated Electrohyperthermia in Mouse Models without Major Immunogenic Effects. International Journal of Molecular Sciences 20:16, pages 4019.
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Tamas Vancsik, Gertrud Forika, Andrea Balogh, Eva Kiss & Tibor Krenacs. (2019) Modulated electro‐hyperthermia induced p53 driven apoptosis and cell cycle arrest additively support doxorubicin chemotherapy of colorectal cancer in vitro. Cancer Medicine 8:9, pages 4292-4303.
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Binh T. Mai, Preethi B. Balakrishnan, Markus J. Barthel, Federica Piccardi, Dina Niculaes, Federica Marinaro, Soraia Fernandes, Alberto Curcio, Hamilton Kakwere, Gwennhael Autret, Roberto Cingolani, Florence Gazeau & Teresa Pellegrino. (2019) Thermoresponsive Iron Oxide Nanocubes for an Effective Clinical Translation of Magnetic Hyperthermia and Heat-Mediated Chemotherapy. ACS Applied Materials & Interfaces 11:6, pages 5727-5739.
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Giammaria Fiorentini, Donatella Sarti, Virginia Casadei, Carlo Milandri, Patrizia Dentico, Andrea Mambrini, Roberto Nani, Caterina Fiorentini & Stefano Guadagni. (2019) Modulated Electro-Hyperthermia as Palliative Treatment for Pancreatic Cancer: A Retrospective Observational Study on 106 Patients. Integrative Cancer Therapies 18, pages 153473541987850.
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Marjorie McDonald, Stéphanie Corde, Michael Lerch, Anatoly Rosenfeld, Michael Jackson & Moeava Tehei. (2018) First in vitro evidence of modulated electro-hyperthermia treatment performance in combination with megavoltage radiation by clonogenic assay. Scientific Reports 8:1.
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P. Tselou. (2017) Monitoring and Imaging of Magnetic Nanoparticles:state-of-the-art and prospective. Journal of Physics: Conference Series 939, pages 012001.
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Sun Young Lee, Na Ri Lee, Dong-Hyu Cho & Jung Soo Kim. (2017) Treatment outcome analysis of chemotherapy combined with modulated electro-hyperthermia compared with chemotherapy alone for recurrent cervical cancer, following irradiation. Oncology Letters 14:1, pages 73-78.
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Gabriella Hegyi. (2017) Oncothermia-Booster (Targeted Radiofrequency) Treatment –in Some Non-Oncological Diseases as Special Physiotherapy. International Journal of Complementary & Alternative Medicine 6:3.
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Mamiko Asano, Minoru Sakaguchi, Satoshi Tanaka, Keiichiro Kashimura, Tomohiko Mitani, Masaya Kawase, Hitoshi Matsumura, Takako Yamaguchi, Yoshikazu Fujita & Katsuyoshi Tabuse. (2017) Effects of Normothermic Conditioned Microwave Irradiation on Cultured Cells Using an Irradiation System with Semiconductor Oscillator and Thermo-regulatory Applicator. Scientific Reports 7:1.
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Oliver Szasz, Marcell A. Szasz, Carrie Minnaar & Andras Szasz. (2017) Heating Preciosity—Trends in Modern Oncological Hyperthermia. Open Journal of Biophysics 07:03, pages 116-144.
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Kai-Lin Yang, Cheng-Chung Huang, Mau-Shin Chi, Hsin-Chien Chiang, Yu-Shan Wang, Chien-Chung Hsia, Gabor Andocs, Hsin-Ell Wang & Kwan-Hwa Chi. (2016) In vitro comparison of conventional hyperthermia and modulated electro-hyperthermia . Oncotarget 7:51, pages 84082-84092.
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Sun Young Lee & Min-Gul Kim. (2016) Effect of Modulated Electrohyperthermia on the Pharmacokinetics of Oral Transmucosal Fentanyl Citrate in Healthy Volunteers. Clinical Therapeutics 38:12, pages 2548-2554.
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G Andocs, M U Rehman, Q-L Zhao, Y Tabuchi, M Kanamori & T Kondo. (2016) Comparison of biological effects of modulated electro-hyperthermia and conventional heat treatment in human lymphoma U937 cells. Cell Death Discovery 2:1.
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Ki Soo Kim, Daniel Hernandez & Soo Yeol Lee. (2015) Time-multiplexed two-channel capacitive radiofrequency hyperthermia with nanoparticle mediation. BioMedical Engineering OnLine 14:1.
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Yuk-Wah Tsang, Cheng-Chung Huang, Kai-Lin Yang, Mau-Shin Chi, Hsin-Chien Chiang, Yu-Shan Wang, Gabor Andocs, Andras Szasz, Wen-Tyng Li & Kwan-Hwa Chi. (2015) Improving immunological tumor microenvironment using electro-hyperthermia followed by dendritic cell immunotherapy. BMC Cancer 15:1.
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SEUNG-GU YEO. (2015) Definitive radiotherapy with concurrent oncothermia for stage IIIB non-small-cell lung cancer: A case report. Experimental and Therapeutic Medicine 10:2, pages 769-772.
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Andocs Gabor, Meggyeshazi Nora, Vancsik Tamas, Krenacs Tibor, Papp Edina, Kovago Csaba & Szasz Oliver. (2015) ITOC2 – 018. Hyperthermia induced immunogenic cell-death. European Journal of Cancer 51, pages S7.
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Gabor Andocs, Nora Meggyeshazi, Lajos Balogh, Sandor Spisak, Mate Elod Maros, Peter Balla, Gergo Kiszner, Ivett Teleki, Csaba Kovago & Tibor Krenacs. (2014) Upregulation of heat shock proteins and the promotion of damage-associated molecular pattern signals in a colorectal cancer model by modulated electrohyperthermia. Cell Stress and Chaperones 20:1, pages 37-46.
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Wei Qin, Yasunori Akutsu, Gabor Andocs, Akiko Suganami, Xin Hu, Gulbostan Yusup, Aki Komatsu-Akimoto, Isamu Hoshino, Naoyuki Hanari, Mikito Mori, Yuka Isozaki, Naoki Akanuma, Yutaka Tamura & Hisahiro Matsubara. (2014) Modulated electro-hyperthermia enhances dendritic cell therapy through an abscopal effect in mice. Oncology Reports.
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N. Meggyeshazi, G. Andocs, L. Balogh, P. Balla, G. Kiszner, I. Teleki, A. Jeney & T. Krenacs. (2014) DNA fragmentation and caspase-independent programmed cell death by modulated electrohyperthermiaDNA-Fragmentierung und caspaseunabhängiger programmierter Zelltod durch modulierte Elektrohyperthermie. Strahlentherapie und Onkologie 190:9, pages 815-822.
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Andras Szasz. (2014) Oncothermia: Complex therapy by EM and fractal physiology. Oncothermia: Complex therapy by EM and fractal physiology.
Andras Szasz. (2014) Current Status of Oncothermia Therapy for Lung Cancer. The Korean Journal of Thoracic and Cardiovascular Surgery 47:2, pages 77-93.
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G. Andocs, N. Meggyeshazi, Y. Okamoto, L. Balogh & O. Szasz. (2013) Bystander Effect of Oncothermia. Conference Papers in Medicine 2013, pages 1-6.
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G. Andocs, Y. Okamoto, K. Kawamoto, T. Osaki, T. Tsuka, T. Imagawa, S. Minami, L. Balogh, N. Meggyeshazi & O. Szasz. (2013) Oncothermia Basic Research at In Vivo Level: The First Results in Japan. Conference Papers in Medicine 2013, pages 1-6.
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Oliver Szasz. (2013) Essentials of Oncothermia. Conference Papers in Medicine 2013, pages 1-20.
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M. Ballerini, G. F. Baronzio, G. Capitò, O. Szasz & V. Cassutti. (2013) Androtherm Application for the Peyronie's Disease. Conference Papers in Medicine 2013, pages 1-6.
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Gyula P. Szigeti, Gabriella Hegyi & Olivér Szasz. (2013) Hyperthermia versus Oncothermia: Cellular Effects in Cancer Therapy. Conference Papers in Medicine 2013, pages 1-4.
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Oliver Szasz, Gabor Andocs & Nora Meggyeshazi. (2013) Oncothermia as Personalized Treatment Option. Conference Papers in Medicine 2013, pages 1-6.
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