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Cancer Biology & Therapy Volume 16, 2015 - Issue 6
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Research Paper

EGFR inhibitors prevent induction of cancer stem-like cells in esophageal squamous cell carcinoma by suppressing epithelial-mesenchymal transition

Fumiyuki SatoDepartment of Gastroenterology and Hepatology; Hokkaido University Graduate School of Medicine; Sapporo, JapanView further author information
,
Yoshimasa KubotaDepartment of Gastroenterology and Hepatology; Hokkaido University Graduate School of Medicine; Sapporo, JapanView further author information
,
Mitsuteru NatsuizakaDepartment of Gastroenterology and Hepatology; Hokkaido University Graduate School of Medicine; Sapporo, JapanCorrespondence[email protected]
View further author information
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Osamu MaeharaPathophysiology and Therapeutics; Hokkaido University Graduate School of Pharmaceutical Science; Sapporo, JapanView further author information
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Yutaka HatanakaDepartment of Surgical Pathology; Hokkaido University Hospital; Sapporo, JapanView further author information
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Katsuji MarukawaDepartment of Surgical Pathology; Hokkaido University Hospital; Sapporo, JapanView further author information
,
Katsumi TerashitaDepartment of Surgical Pathology; Hokkaido University Hospital; Sapporo, JapanView further author information
,
Goki SudaDepartment of Gastroenterology and Hepatology; Hokkaido University Graduate School of Medicine; Sapporo, JapanView further author information
,
Shunsuke OhnishiDepartment of Gastroenterology and Hepatology; Hokkaido University Graduate School of Medicine; Sapporo, JapanView further author information
,
Yuichi ShimizuDepartment of Gastroenterology and Hepatology; Hokkaido University Graduate School of Medicine; Sapporo, JapanView further author information
,
Yoshito KomatsuDepartment of Gastroenterology and Hepatology; Hokkaido University Graduate School of Medicine; Sapporo, JapanView further author information
,
Shinya OhashiDepartment of Therapeutic Oncology; Kyoto University Graduate School of Medicine; Kyoto, JapanView further author information
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Shingo KagawaDepartment of General Surgery; Chiba University Graduate School of Medicine; Chiba, JapanView further author information
,
Hideaki KinugasaDepartment of Gastroenterology and Hepatology; Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences; Okayama, JapanView further author information
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Kelly A WhelanGastroenterology Division; University of Pennsylvania; Philadelphia, PAUSA;Abramson Cancer Center; Philadelphia, PAUSAView further author information
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Hiroshi NakagawaGastroenterology Division; University of Pennsylvania; Philadelphia, PAUSA;Abramson Cancer Center; Philadelphia, PAUSAView further author information
&
Naoya SakamotoDepartment of Gastroenterology and Hepatology; Hokkaido University Graduate School of Medicine; Sapporo, JapanView further author information
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Pages 933-940 | Received 12 Jan 2015, Accepted 09 Apr 2015, Published online: 28 May 2015

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Osamu Maehara, Goki Suda, Mitsuteru Natsuizaka, Taku Shigesawa, Gouki Kanbe, Megumi Kimura, Masaya Sugiyama, Masashi Mizokami, Masato Nakai, Takuya Sho, Kenichi Morikawa, Koji Ogawa, Shinya Ohashi, Shingo Kagawa, Hideaki Kinugasa, Seiji Naganuma, Naoto Okubo, Shunsuke Ohnishi, Hiroshi Takeda & Naoya Sakamoto. (2021) FGFR2 maintains cancer cell differentiation via AKT signaling in esophageal squamous cell carcinoma. Cancer Biology & Therapy 22:5-6, pages 372-380.
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Yongxu Chen, Wei Tan & Changjun Wang. (2018) Tumor-associated macrophage-derived cytokines enhance cancer stem-like characteristics through epithelial–mesenchymal transition. OncoTargets and Therapy 11, pages 3817-3826.
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Xia Qian, Cheng Tan, Feng Wang, Baixia Yang, Yangyang Ge, Zhifeng Guan & Jing Cai. (2016) Esophageal cancer stem cells and implications for future therapeutics. OncoTargets and Therapy 9, pages 2247-2254.
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Maddaly Ravi, Aarthi Ramesh & Aishwarya Pattabhi. (2017) Contributions of 3D Cell Cultures for Cancer Research. Journal of Cellular Physiology 232:10, pages 2679-2697.
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Ugo Testa, Germana Castelli & Elvira Pelosi. (2017) Esophageal Cancer: Genomic and Molecular Characterization, Stem Cell Compartment and Clonal Evolution. Medicines 4:3, pages 67.
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Ya-Jing Lv, Wei Wang, Chu-Shu Ji, Jia, Ming-Ran Xie & Bing Hu. (2017) Association between periostin and epithelial-mesenchymal transition in esophageal squamous cell carcinoma and its clinical significance. Oncology Letters 14:1, pages 376-382.
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Jeong-Yeon Lee & Gu Kong. (2016) Roles and epigenetic regulation of epithelial–mesenchymal transition and its transcription factors in cancer initiation and progression. Cellular and Molecular Life Sciences 73:24, pages 4643-4660.
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Sheng-Ta Tsai, Po-Jen Wang, Nia-Jhen Liou, Pei-Shan Lin, Chung-Hsuan Chen & Wei-Chao Chang. (2015) ICAM1 Is a Potential Cancer Stem Cell Marker of Esophageal Squamous Cell Carcinoma. PLOS ONE 10:11, pages e0142834.
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