2,432
Views
71
CrossRef citations to date
0
Altmetric
Research Paper

MiR-15a and miR-16 induce autophagy and enhance chemosensitivity of Camptothecin

, , , , , , & show all
Pages 941-948 | Received 09 Feb 2015, Accepted 09 Apr 2015, Published online: 28 May 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Zheng He, Lianhua Yu, Shiyi Luo, Qi Li, Shuhong Huang & Yunhe An. (2019) RGS4 Regulates Proliferation And Apoptosis Of NSCLC Cells Via microRNA-16 And Brain-Derived Neurotrophic Factor. OncoTargets and Therapy 12, pages 8701-8714.
Read now
Hui Du & Ying Chen. (2019) Competing endogenous RNA networks in cervical cancer: function, mechanism and perspective. Journal of Drug Targeting 27:7, pages 709-723.
Read now
Deniz Gulfem Ozturk, Muhammed Kocak, Arzu Akcay, Kubilay Kinoglu, Erdogan Kara, Yalcin Buyuk, Hilal Kazan & Devrim Gozuacik. (2019) MITF-MIR211 axis is a novel autophagy amplifier system during cellular stress. Autophagy 15:3, pages 375-390.
Read now
Shi Yin, Wenzhong Du, Feng Wang, Bo Han, Yuqiong Cui, Dongbo Yang, Hui Chen, Daming Liu, Xing Liu, Xiuwei Zhai & Chuanlu Jiang. (2018) MicroRNA-326 sensitizes human glioblastoma cells to curcumin via the SHH/GLI1 signaling pathway. Cancer Biology & Therapy 19:4, pages 260-270.
Read now
Jian Zhang, Peiyuan Wang, Lin Wan, Shouping Xu & Da Pang. (2017) The emergence of noncoding RNAs as Heracles in autophagy. Autophagy 13:6, pages 1004-1024.
Read now
Fang Hua, Shuang Shang & Zhuo-Wei Hu. (2017) Seeking new anti-cancer agents from autophagy-regulating natural products. Journal of Asian Natural Products Research 19:4, pages 305-313.
Read now
Fan Wang, Haoxiang Zhang, Naihan Xu, Nunu Huang, Caiming Tian, Anlin Ye, Guangnan Hu, Jie He & Yaou Zhang. (2016) A novel hypoxia-induced miR-147a regulates cell proliferation through a positive feedback loop of stabilizing HIF-1α. Cancer Biology & Therapy 17:8, pages 790-798.
Read now

Articles from other publishers (64)

Shantanu Gupta, Daner A. Silveira, José Carlos M. Mombach & Ronaldo F. Hashimoto. (2023) The lncRNA DLX6-AS1/miR-16-5p axis regulates autophagy and apoptosis in non-small cell lung cancer: A Boolean model of cell death. Non-coding RNA Research 8:4, pages 605-614.
Crossref
Siva Prasad Panda & Vikrant Singh. (2023) The Dysregulated MAD in Mad: A Neuro-theranostic Approach Through the Induction of Autophagic Biomarkers LC3B-II and ATG. Molecular Neurobiology 60:9, pages 5214-5236.
Crossref
Jin Li, Xianyanling Yi, Liangren Liu, Xiaohui Wang & Jianzhong Ai. (2023) Advances in tumor nanotechnology: theragnostic implications in tumors via targeting regulated cell death. Apoptosis 28:7-8, pages 1198-1215.
Crossref
Aliasgar Fakruddin Shahiwala & Gazala Afreen Khan. (2023) Potential Phytochemicals for Prevention of Familial Breast Cancer with BRCA Mutations. Current Drug Targets 24:6, pages 521-531.
Crossref
Mustafa M. Kadhim, Andrés Alexis Ramírez-Coronel, Abduladheem Turki Jalil, Hayder Abdullah Talib, Jitendra Gupta, Zanko Hassan Jawhar, Marwan Mahmood Saleh, Vijay Pandey, Xi Zhang & Haroon Khan. (2023) Autophagy as a self-digestion signal in human cancers: Regulation by microRNAs in affecting carcinogenesis and therapy response. Pharmacological Research 189, pages 106695.
Crossref
Yanan Sun, Huihui Wang, Taiqi Qu, Junjie Luo, Peng An, Fazheng Ren, Yongting Luo & Yixuan Li. (2023) mTORC2: a multifaceted regulator of autophagy. Cell Communication and Signaling 21:1.
Crossref
Joseph Landry, Kathryn Shows, Akash Jagdeesh, Aashka Shah, Mihir Pokhriyal & Vasily Yakovlev. 2023.
Di Wu, Wenjie Zhao, Chengjuan Xu, Xin Zhou, Xia Leng & Yanmin Li. (2022) Melatonin suppresses serum starvation-induced autophagy of ovarian granulosa cells in premature ovarian insufficiency. BMC Women's Health 22:1.
Crossref
Shalini Mani, Divya Jindal, Hitesh Chopra, Saurabh Kumar Jha, Sachin Kumar Singh, Gulam Md Ashraf, Mehnaz Kamal, Danish Iqbal, Dinesh Kumar Chellappan, Abhijit Dey, Saikat Dewanjee, Keshav K. Singh, Shreesh Ojha, Inderbir Singh, Rupesh K. Gautam & Niraj Kumar Jha. (2022) ROCK2 inhibition: A futuristic approach for the management of Alzheimer’s disease. Neuroscience & Biobehavioral Reviews 142, pages 104871.
Crossref
Mahasin Abdel Rhman & Owira PMO. (2022) Potential therapeutic applications of microRNAs in cancer diagnosis and treatment: Sharpening a double-edged sword?. European Journal of Pharmacology 932, pages 175210.
Crossref
Pei-Feng Liu, Ammad Ahmad Farooqi, Sheng-Yao Peng, Tzu-Jung Yu, Hans-Uwe Dahms, Cheng-Hsin Lee, Jen-Yang Tang, Sheng-Chieh Wang, Chih-Wen Shu & Hsueh-Wei Chang. (2022) Regulatory effects of noncoding RNAs on the interplay of oxidative stress and autophagy in cancer malignancy and therapy. Seminars in Cancer Biology 83, pages 269-282.
Crossref
Sajad Rashidi, Reza Mansouri, Mohammad Ali-Hassanzadeh, Esmaeel Ghani, Mohammadreza Karimazar, Antonio Muro, Paul Nguewa & Raúl Manzano-Román. (2022) miRNAs in the regulation of mTOR signaling and host immune responses: The case of Leishmania infections. Acta Tropica 231, pages 106431.
Crossref
Alfredo Lagunas-Martínez, Vicente Madrid-Marina, Claudia Gómez-Cerón, Jessica Deas & Oscar Peralta-Zaragoza. (2022) The Autophagy Process in Cervical Carcinogenesis: Role of Non-Coding-RNAs, Molecular Mechanisms, and Therapeutic Targets. Cells 11:8, pages 1323.
Crossref
Shantanu Gupta, Pritam Kumar Panda, Ronaldo F. Hashimoto, Shailesh Kumar Samal, Suman Mishra, Suresh Kr. Verma, Yogendra Kumar Mishra & Rajeev Ahuja. (2022) Dynamical modeling of miR-34a, miR-449a, and miR-16 reveals numerous DDR signaling pathways regulating senescence, autophagy, and apoptosis in HeLa cells. Scientific Reports 12:1.
Crossref
Rhett Visintin & Swapan K. Ray. (2022) Specific microRNAs for Modulation of Autophagy in Spinal Cord Injury. Brain Sciences 12:2, pages 247.
Crossref
Qiuqin Ma, Shihui Long, Zhending Gan, Gianluca Tettamanti, Kang Li & Ling Tian. (2022) Transcriptional and Post-Transcriptional Regulation of Autophagy. Cells 11:3, pages 441.
Crossref
Yue Wang, Shengchen Wang, Hongyuan Jing, Tianyi Zhang, Nuan Song & Shiwen Xu. (2022) CircRNA-IGLL1/miR-15a/RNF43 axis mediates ammonia-induced autophagy in broilers jejunum via Wnt/β-catenin pathway. Environmental Pollution 292, pages 118332.
Crossref
Hui Zou, Ling Wang, Jianya Zhao, Yan Yuan, Tao Wang, Jianchun Bian & Zongping Liu. (2021) MiR-155 promotes cadmium-induced autophagy in rat hepatocytes by suppressing Rheb expression. Ecotoxicology and Environmental Safety 227, pages 112895.
Crossref
Ying Zhang, Qingsong Tie, Zhiwei Bao, Zhi Shao & Lan Zhang. (2021) Inhibition of miR-15a-5p Promotes the Chemoresistance to Pirarubicin in Hepatocellular Carcinoma via Targeting eIF4E. Computational and Mathematical Methods in Medicine 2021, pages 1-11.
Crossref
Chenyu Mao, Xin Xu, Yongfeng Ding & Nong Xu. (2021) Optimization of BCG Therapy Targeting Neutrophil Extracellular Traps, Autophagy, and miRNAs in Bladder Cancer: Implications for Personalized Medicine. Frontiers in Medicine 8.
Crossref
Josué Ballesteros‐Álvarez & Julie K. Andersen. (2021) mTORC2: The other mTOR in autophagy regulation. Aging Cell 20:8.
Crossref
Marwa M. Mahmoud, Eman F. Sanad & Nadia M. Hamdy. (2021) MicroRNAs’ role in the environment-related non-communicable diseases and link to multidrug resistance, regulation, or alteration. Environmental Science and Pollution Research 28:28, pages 36984-37000.
Crossref
Jiani He, Zhongkai Qiu, Hao Zhang, Zhipeng Gao, Yuanjun Jiang, Zhenhua Li, Chuize Kong & Xiaojun Man. (2021) MicroRNA‑16‑5p/BIMP1/NF‑κB axis regulates autophagy to exert a tumor‑suppressive effect on bladder cancer. Molecular Medicine Reports 24:2.
Crossref
Michele Aventaggiato, Enza Vernucci, Federica Barreca, Matteo A. Russo & Marco Tafani. (2021) Sirtuins' control of autophagy and mitophagy in cancer. Pharmacology & Therapeutics 221, pages 107748.
Crossref
Audrey J. Weber & Jeremy H. Herskowitz. (2021) Perspectives on ROCK2 as a Therapeutic Target for Alzheimer’s Disease. Frontiers in Cellular Neuroscience 15.
Crossref
Sriharikrishnaa S, Vaibhav Shukla, G Nadeem Khan, Sangavi Eswaran, Divya Adiga & Shama Prasada Kabekkodu. (2021) Integrated bioinformatic analysis of miR-15a/16-1 cluster network in cervical cancer. Reproductive Biology 21:1, pages 100482.
Crossref
Tian-Jia Liu, Shuang Hu, Zhi-Dong Qiu & Da Liu. (2021) Anti-Tumor Mechanisms Associated With Regulation of Non-Coding RNA by Active Ingredients of Chinese Medicine: A Review. Frontiers in Oncology 10.
Crossref
Yu Jeong Kim, Won June Lee, Byoung-Woo Ko, Han Woong Lim, Yeji Yeon, Seong Joon Ahn & Byung Ro Lee. (2021) Investigation of MicroRNA Expression in Anterior Lens Capsules of Senile Cataract Patients and MicroRNA Differences According to the Cataract Type. Translational Vision Science & Technology 10:2, pages 14.
Crossref
Mohammad Hossein Pourhanifeh, Maryam Mahjoubin-Tehran, Mohammad Reza Karimzadeh, Hamid Reza Mirzaei, Zahra Sadat Razavi, Amirhossein Sahebkar, Nayyerehsadat Hosseini, Hamed Mirzaei & Michael R. Hamblin. (2020) Autophagy in cancers including brain tumors: role of MicroRNAs. Cell Communication and Signaling 18:1.
Crossref
Shantanu Gupta, Daner A. Silveira & José Carlos M. Mombach. (2020) Towards DNA-damage induced autophagy: A Boolean model of p53-induced cell fate mechanisms. DNA Repair 96, pages 102971.
Crossref
Yuanming Jing, Wenqing Liang, Jian Liu, Lin Zhang, Jianguo Wei, Jianhui Yang, Yu Zhang & Zongliang Huang. (2020) Autophagy-mediating microRNAs in cancer chemoresistance. Cell Biology and Toxicology 36:6, pages 517-536.
Crossref
Bolin Hou, Shuchun Liu, Erwei Li & Xuejun Jiang. (2020) Different Role of Raptor and Rictor in Regulating Rasfonin‐Induced Autophagy and Apoptosis in Renal Carcinoma Cells. Chemistry & Biodiversity 17:12.
Crossref
Kai Wang, Yanbei Tu, Jian-Bo Wan, Meiwan Chen & Chengwei He. (2020) Synergistic anti-breast cancer effect of pulsatilla saponin D and camptothecin through interrupting autophagic–lysosomal function and promoting p62-mediated ubiquitinated protein aggregation. Carcinogenesis 41:6, pages 804-816.
Crossref
Yunus Akkoc & Devrim Gozuacik. (2020) MicroRNAs as major regulators of the autophagy pathway. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1867:5, pages 118662.
Crossref
Longfang Guo, Caining Zhang, Quan Gao, Bolin Hou, Ling Liu, Huaiyi Yang & Xuejun Jiang. (2020) Chloropupukeananin and Pestalofone C Regulate Autophagy through AMPK and Glycolytic Pathway. Chemistry & Biodiversity 17:3.
Crossref
Pei-Cheng Jiang & Shu-Rui Bu. (2019) Clinical value of circular RNAs and autophagy-related miRNAs in the diagnosis and treatment of pancreatic cancer. Hepatobiliary & Pancreatic Diseases International 18:6, pages 511-516.
Crossref
Helena Aspernig, Thomas Heimbucher, Wenjing Qi, Dipak Gangurde, Sedric Curic, Yijian Yan, Erika Donner von Gromoff, Ralf Baumeister & Antje Thien. (2019) Mitochondrial Perturbations Couple mTORC2 to Autophagy in C. elegans. Cell Reports 29:6, pages 1399-1409.e5.
Crossref
Javid Sadri Nahand, Sima Taghizadeh‐boroujeni, Mohammad Karimzadeh, Sarina Borran, Mohammad Hossein Pourhanifeh, Mohsen Moghoofei, Farah Bokharaei‐Salim, Sajad Karampoor, Amir Jafari, Zatollah Asemi, Alireza Tbibzadeh, Afshin Namdar & Hamed Mirzaei. (2019) microRNAs: New prognostic, diagnostic, and therapeutic biomarkers in cervical cancer. Journal of Cellular Physiology 234:10, pages 17064-17099.
Crossref
Jiahao Lin, Lie Ma, Di Zhang, Jiafeng Gao, Yipeng Jin, Zhihai Han & Degui Lin. (2019) Tumour biomarkers—Tracing the molecular function and clinical implication. Cell Proliferation 52:3.
Crossref
Shiksha Sharma & Minakshi Vashist. (2019) MicroRNA in Cervical Carcinogenesis: Window of Therapeutic Potential. Current Women s Health Reviews 15:3, pages 171-178.
Crossref
Jurgen Kriel & Ben Loos. (2019) The good, the bad and the autophagosome: exploring unanswered questions of autophagy-dependent cell death. Cell Death & Differentiation 26:4, pages 640-652.
Crossref
Menghao Chen, Xiaojing Li, Ruifeng Fan, Jie Yang, Xi Jin, Sattar Hamid & Shiwen Xu. (2018) Cadmium induces BNIP3-dependent autophagy in chicken spleen by modulating miR-33-AMPK axis. Chemosphere 194, pages 396-402.
Crossref
Abdullah Al Hasan & A.T.M. Zafrul Azam. 2018. Design of Nanostructures for Theranostics Applications. Design of Nanostructures for Theranostics Applications 341 436 .
Minsu Jang, Hyunju Kim, Rackhyun Park, Daum Jo, Eun-Ju Lee, Won Keun Oh & Junsoo Park. (2017) 2,2′-Methylenebis (6-tert-butyl 4-methylphenol) enhances the antitumor efficacy of belotecan, a derivative of camptothecin, by inducing autophagy. Oncotarget 8:70, pages 115068-115078.
Crossref
Wenjun Yin, Yuehua Nie, Lingying Chen, Quipping Wang, Shuangquan Liu, Xiusheng He & Wenjun Wang. (2017) Deregulation of microRNA-193b affects the proliferation of liver cancer via myeloid cell leukemia-1. Oncology Letters.
Crossref
Jesús Adrián López & Angelica Judith Granados López. 2017. Colposcopy and Cervical Pathology. Colposcopy and Cervical Pathology.
Muralidharan Jayaraman, Rangasudhagar Radhakrishnan, Cara A. Mathews, Mingda Yan, Sanam Husain, Katherine M. Moxley, Yong Sang Song & Danny N. Dhanasekaran. (2017) Identification of novel diagnostic and prognostic miRNA signatures in endometrial cancer. Genes & Cancer 8:5-6, pages 566-576.
Crossref
Lisha Zha, Lichun He, Weidong Xie, Jin Cheng, Tong Li, Mona O. Mohsen, Fan Lei, Federico Storni, Martin Bachmann, Hongquan Chen & Yaou Zhang. (2017) Therapeutic silence of pleiotrophin by targeted delivery of siRNA and its effect on the inhibition of tumor growth and metastasis. PLOS ONE 12:5, pages e0177964.
Crossref
Devrim Gozuacik, Yunus Akkoc, Deniz Gulfem Ozturk & Muhammed Kocak. (2017) Autophagy-Regulating microRNAs and Cancer. Frontiers in Oncology 7.
Crossref
Wei Zhou, Libo Liu, Yixue Xue, Jian Zheng, Xiaobai Liu, Jun Ma, Zhen Li & Yunhui Liu. (2017) Combination of Endothelial-Monocyte-Activating Polypeptide-II with Temozolomide Suppress Malignant Biological Behaviors of Human Glioblastoma Stem Cells via miR-590-3p/MACC1 Inhibiting PI3K/AKT/mTOR Signal Pathway. Frontiers in Molecular Neuroscience 10.
Crossref
Angelica Granados-López, José Ruiz-Carrillo, Luis Servín-González, José Martínez-Rodríguez, Claudia Reyes-Estrada, Rosalinda Gutiérrez-Hernández & Jesús López. (2017) Use of Mature miRNA Strand Selection in miRNAs Families in Cervical Cancer Development. International Journal of Molecular Sciences 18:2, pages 407.
Crossref
Xin An, Cesar Sarmiento, Tao Tan & Hua Zhu. (2017) Regulation of multidrug resistance by microRNAs in anti-cancer therapy. Acta Pharmaceutica Sinica B 7:1, pages 38-51.
Crossref
Dahong Yao, Yingnan Jiang, Suyu Gao, Lei Shang, Yuqian Zhao, Jian Huang, Jinhui Wang, Shilin Yang & Lixia Chen. (2016) Deconvoluting the complexity of microRNAs in autophagy to improve potential cancer therapy. Cell Proliferation 49:5, pages 541-553.
Crossref
Bernhard Biersack. (2016) Non-coding RNA/microRNA-modulatory dietary factors and natural products for improved cancer therapy and prevention: Alkaloids, organosulfur compounds, aliphatic carboxylic acids and water-soluble vitamins. Non-coding RNA Research 1:1, pages 51-63.
Crossref
Luocheng Li, Zhiwei Wang, Xiaoping Hu, Ting Wan, Hongbing Wu, Wanli Jiang & Rui Hu. (2016) Human aortic smooth muscle cell-derived exosomal miR-221/222 inhibits autophagy via a PTEN/Akt signaling pathway in human umbilical vein endothelial cells. Biochemical and Biophysical Research Communications 479:2, pages 343-350.
Crossref
David E. Lee, Jacob L. Brown, Megan E. Rosa, Lemuel A. Brown, Richard A. PerryJr.Jr., Michael P. Wiggs, Mats I. Nilsson, Stephen F. Crouse, James D. Fluckey, Tyrone A. Washington & Nicholas P. Greene. (2016) microRNA-16 Is Downregulated During Insulin Resistance and Controls Skeletal Muscle Protein Accretion. Journal of Cellular Biochemistry 117:8, pages 1775-1787.
Crossref
Qingrong Huang, Bo Xiao, Xinting Ma, Mingjuan Qu, Yanmin Li, Prakash Nagarkatti, Mitzi Nagarkatti & Juhua Zhou. (2016) MicroRNAs associated with the pathogenesis of multiple sclerosis. Journal of Neuroimmunology 295-296, pages 148-161.
Crossref
Erika Larrea, Carla Sole, Lorea Manterola, Ibai Goicoechea, María Armesto, María Arestin, María Caffarel, Angela Araujo, María Araiz, Marta Fernandez-Mercado & Charles Lawrie. (2016) New Concepts in Cancer Biomarkers: Circulating miRNAs in Liquid Biopsies. International Journal of Molecular Sciences 17:5, pages 627.
Crossref
Xueyuan Tang, Long Jin, Peiguo Cao, Ke Cao, Chenghui Huang, Yanwei Luo, Jian Ma, Shourong Shen, Ming Tan, Xiayu Li & Ming Zhou. (2016) MicroRNA-16 sensitizes breast cancer cells to paclitaxel through suppression of IKBKB expression. Oncotarget 7:17, pages 23668-23683.
Crossref
Qingmei He, Xianyue Ren, Jiewei Chen, Yingqin Li, Xinran Tang, Xin Wen, Xiaojing Yang, Jian Zhang, Yaqin Wang, Jun Ma & Na Liu. (2015) miR-16 targets fibroblast growth factor 2 to inhibit NPC cell proliferation and invasion via PI3K/AKT and MAPK signaling pathways. Oncotarget 7:3, pages 3047-3058.
Crossref
Xueman Chen, Siting Fan & Erwei Song. 2016. The Long and Short Non-coding RNAs in Cancer Biology. The Long and Short Non-coding RNAs in Cancer Biology 1 47 .
Banzhou Pan, Bing Feng, Yitian Chen, Guichun Huang, Rui Wang, Longbang Chen & Haizhu Song. (2015) MiR-200b regulates autophagy associated with chemoresistance in human lung adenocarcinoma. Oncotarget 6:32, pages 32805-32820.
Crossref
Yanxiang Cheng, Gantao Chen, Min Hu, Jinling Huang, Binshu Li, Limei Zhou & Li Hong. (2015) Has-miR-30a regulates autophagic activity in cervical cancer upon hydroxycamptothecin exposure. Biomedicine & Pharmacotherapy 75, pages 67-74.
Crossref
Helena Aspernig, Wenjing Qi, Yijian Yan, Erika Donner von Gromoff, Ralf Baumeister & Antje Thien. (2019) Mitochondrial Perturbations Couple mTORC2 to Autophagy in <i>C. elegans</i>. SSRN Electronic Journal.
Crossref