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The irony of highly-effective bacterial therapy of a patient-derived orthotopic xenograft (PDOX) model of Ewing's sarcoma, which was blocked by Ewing himself 80 years ago

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Pages 1046-1052 | Received 19 Jan 2017, Accepted 06 Mar 2017, Published online: 11 May 2017

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Kei Kawaguchi, Kentaro Igarashi, Kentaro Miyake, Tasuku Kiyuna, Masuyo Miyake, Arun S. Singh, Bartosz Chmielowski, Scott D. Nelson, Tara A. Russell, Sarah M. Dry, Yunfeng Li, Michiaki Unno, Shree Ram Singh, Fritz C. Eilber & Robert M. Hoffman. (2019) Patterns of sensitivity to a panel of drugs are highly individualised for undifferentiated/unclassified soft tissue sarcoma (USTS) in patient-derived orthotopic xenograft (PDOX) nude-mouse models. Journal of Drug Targeting 27:2, pages 211-216.
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Kei Kawaguchi, Kentaro Miyake, Ming Zhao, Tasuku Kiyuna, Kentaro Igarashi, Masuyo Miyake, Takashi Higuchi, Hiromichi Oshiro, Michael Bouvet, Michiaki Unno & Robert M. Hoffman. (2018) Tumor targeting Salmonella typhimurium A1-R in combination with gemcitabine (GEM) regresses partially GEM-resistant pancreatic cancer patient-derived orthotopic xenograft (PDOX) nude mouse models. Cell Cycle 17:16, pages 2019-2026.
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Kei Kawaguchi, Kentaro Miyake, Qinghong Han, Shukuan Li, Yuying Tan, Kentaro Igarashi, Thinzar M. Lwin, Takashi Higuchi, Tasuku Kiyuna, Masuyo Miyake, Hiromichi Oshiro, Michael Bouvet, Michiaki Unno & Robert M. Hoffman. (2018) Targeting altered cancer methionine metabolism with recombinant methioninase (rMETase) overcomes partial gemcitabine-resistance and regresses a patient-derived orthotopic xenograft (PDOX) nude mouse model of pancreatic cancer. Cell Cycle 17:7, pages 868-873.
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Kentaro Igarashi, Kei Kawaguchi, Tasuku Kiyuna, Kentaro Miyake, Masuyo Miyake, Shukuan Li, Qinghong Han, Yuying Tan, Ming Zhao, Yunfeng Li, Scott D. Nelson, Sarah M. Dry, Arun S. Singh, Irmina A. Elliott, Tara A. Russell, Mark A. Eckardt, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Hiroyuki Tsuchiya, Fritz C. Eilber & Robert M. Hoffman. (2018) Tumor-targeting Salmonella typhimurium A1-R combined with recombinant methioninase and cisplatinum eradicates an osteosarcoma cisplatinum-resistant lung metastasis in a patient-derived orthotopic xenograft (PDOX) mouse model: decoy, trap and kill chemotherapy moves toward the clinic. Cell Cycle 17:6, pages 801-809.
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Kentaro Miyake, Kei Kawaguchi, Tasuku Kiyuna, Masuyo Miyake, Kentaro Igarashi, Zhiying Zhang, Takashi Murakami, Yunfeng Li, Scott D. Nelson, Irmina Elliott, Tara Russell, Arun Singh, Yukihiko Hiroshima, Masashi Momiyama, Ryusei Matsuyama, Takashi Chishima, Itaru Endo, Fritz C. Eilber & Robert M. Hoffman. (2018) Regorafenib regresses an imatinib-resistant recurrent gastrointestinal stromal tumor (GIST) with a mutation in exons 11 and 17 of c-kit in a patient-derived orthotopic xenograft (PDOX) nude mouse model. Cell Cycle 17:6, pages 722-727.
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Kei Kawaguchi, Kentaro Igarashi, Tasuku Kiyuna, Kentaro Miyake, Masuyo Miyake, Takashi Murakami, Bartosz Chmielowski, Scott D. Nelson, Tara A. Russell, Sarah M. Dry, Yunfeng Li, Arun S. Singh, Michiaki Unno, Fritz C. Eilber & Robert M. Hoffman. (2018) Individualized doxorubicin sensitivity testing of undifferentiated soft tissue sarcoma (USTS) in a patient-derived orthotopic xenograft (PDOX) model demonstrates large differences between patients. Cell Cycle 17:5, pages 627-633.
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Kentaro Miyake, Takashi Murakami, Tasuku Kiyuna, Kentaro Igarashi, Kei Kawaguchi, Masuyo Miyake, Yunfeng Li, Scott D. Nelson, Sarah M. Dry, Michael Bouvet, Irmina A. Elliott, Tara A. Russell, Arun S. Singh, Mark A. Eckardt, Yukihiko Hiroshima, Masashi Momiyama, Ryusei Matsuyama, Takashi Chishima, Itaru Endo, Fritz C. Eilber & Robert M. Hoffman. (2017) The combination of temozolomide-irinotecan regresses a doxorubicin-resistant patient-derived orthotopic xenograft (PDOX) nude-mouse model of recurrent Ewing’s sarcoma with a FUS-ERG fusion and CDKN2A deletion: Direction for third-line patient therapy . Oncotarget 8:61, pages 103129-103136.
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Robert M. Hoffman. 2017. Patient-Derived Mouse Models of Cancer. Patient-Derived Mouse Models of Cancer 183 192 .

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