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COPD: Journal of Chronic Obstructive Pulmonary Disease Volume 3, 2006 - Issue 2
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ORIGINAL RESEARCH

Inhaled Recombinant Alpha 1-Antitrypsin Ameliorates Cigarette Smoke-Induced Emphysema in the Mouse

Philip A. Pemberton Arriva Pharmaceuticals, Inc., Alameda, California, USA; Department of Pediatrics, Washington University, St. Louis, Missouri, USA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, Massachusetts, USA
,
Dale Kobayashi Department of Pediatrics, Washington University, St. Louis, Missouri, USA
,
Barry J. Wilk Arriva Pharmaceuticals, Inc., Alameda, California, USA
,
John M. Henstrand Arriva Pharmaceuticals, Inc., Alameda, California, USA
,
Steven D. Shapiro Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, Massachusetts, USA
&
Philip J. Barr Arriva Pharmaceuticals, Inc., Alameda, California, USA
Pages 101-108 | Published online: 02 Jul 2009

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Concetta Gardi, Blerta Stringa & Piero A Martorana. (2015) Animal models for anti-emphysema drug discovery. Expert Opinion on Drug Discovery 10:4, pages 399-410.
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Robert A Stockley. (2010) Emerging drugs for alpha-1-antitrypsin deficiency. Expert Opinion on Emerging Drugs 15:4, pages 685-694.
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Carola Seifart & Claus Vogelmeier. (2009) Emerging drugs in chronic obstructive pulmonary disease. Expert Opinion on Emerging Drugs 14:1, pages 181-194.
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Caroline A Owen. (2008) Roles for proteinases in the pathogenesis of chronic obstructive pulmonary disease. International Journal of Chronic Obstructive Pulmonary Disease 3:2, pages 253-268.
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Willem I de Boer, Hongwei Yao & Irfan Rahman. (2007) Future therapeutic treatment of COPD: Struggle between oxidants and cytokines. International Journal of Chronic Obstructive Pulmonary Disease 2:3, pages 205-228.
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Articles from other publishers (20)

Katsuyuki Takeda, Soo-Hyun Kim, Anthony Joetham, Irina Petrache & Erwin W. Gelfand. (2021) Therapeutic benefits of recombinant alpha1-antitrypsin IgG1 Fc-fusion protein in experimental emphysema. Respiratory Research 22:1.
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Matthew J. McNulty, David Z. Silberstein, Brooks T. Kuhn, Hal S. Padgett, Somen Nandi, Karen A. McDonald & Carroll E. Cross. (2021) Alpha-1 antitrypsin deficiency and recombinant protein sources with focus on plant sources: Updates, challenges and perspectives. Free Radical Biology and Medicine 163, pages 10-30.
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Rashika Joshi, Mohit Ojha, Jana Lewis, Qiang Fan, Brett Monia, Shuling Guo & Brian M. Varisco. (2019) Sex-specific differences in emphysema using a murine antisense oligonucleotide model of α-1 antitrypsin deficiency. American Journal of Physiology-Lung Cellular and Molecular Physiology 316:6, pages L1165-L1173.
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Adriana Feliciano Alves Duran, Luana de Paiva Neves, Flavia Ribeiro Santos da Silva, Gabriel Capella Machado, Graziele Cristina Ferreira, Juliana D. Lourenço, Aparecida Sadae Tanaka, Milton de Arruda Martins, Fernanda D.T.Q.S. Lopes & Sergio Daishi Sasaki. (2018) rBmTI-6 attenuates pathophysiological and inflammatory parameters of induced emphysema in mice. International Journal of Biological Macromolecules 111, pages 1214-1221.
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Dieter Köhler. (2017) Alpha-1-Antitrypsin-Mangel: Ist die Substitution ein Mythos?. Deutsches Ärzteblatt Online.
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Clifford Taggart, Marcus A. Mall, Gilles Lalmanach, Didier Cataldo, Andreas Ludwig, Sabina Janciauskiene, Nicole Heath, Silke Meiners, Christopher M. Overall, Carsten Schultz, Boris Turk & Keren S. Borensztajn. (2017) Protean proteases: at the cutting edge of lung diseases. European Respiratory Journal 49:2, pages 1501200.
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Nasim Nosoudi, Vaideesh Parasaram, Saketh Karamched, Aniqa Chowdhury & Naren Vyavahare. 2016. Elastic Fiber Matrices. Elastic Fiber Matrices 189 226 .
D. Rivera-Burgos, U. Sarkar, A. R. Lever, M. J. Avram, J. R. Coppeta, J. S. Wishnok, J. T. Borenstein & S. R. Tannenbaum. (2015) Glucocorticoid Clearance and Metabolite Profiling in an In Vitro Human Airway Epithelium Lung Model. Drug Metabolism and Disposition 44:2, pages 220-226.
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Adam Wanner. 2016. Alpha-1 Antitrypsin. Alpha-1 Antitrypsin 141 155 .
Christian Herr, Gang Han, Dong Li, Thomas Tschernig, Quoc Thai Dinh, Christoph Beißwenger & Robert Bals. (2015) Combined exposure to bacteria and cigarette smoke resembles characteristic phenotypes of human COPD in a murine disease model. Experimental and Toxicologic Pathology 67:3, pages 261-269.
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Jefferey L Burgess, Margaret Kurzius-Spencer, Gerald S Poplin, Sally R Littau, Michael J Kopplin, Stefan Stürup, Scott Boitano & R Clark Lantz. (2013) Environmental arsenic exposure, selenium and sputum alpha-1 antitrypsin. Journal of Exposure Science & Environmental Epidemiology 24:2, pages 150-155.
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Eli C Lewis. (2012) Expanding the Clinical Indications for α1-Antitrypsin Therapy. Molecular Medicine 18:6, pages 957-970.
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Andrew Churg, Don D. Sin & Joanne L. Wright. (2011) Everything Prevents Emphysema. American Journal of Respiratory Cell and Molecular Biology 45:6, pages 1111-1115.
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Marie-Louise Zani, Annabelle Tanga, Ahlame Saidi, Hélène Serrano, Sandrine Dallet-Choisy, Kévin Baranger & Thierry Moreau. (2011) SLPI and trappin-2 as therapeutic agents to target airway serine proteases in inflammatory lung diseases: current and future directions. Biochemical Society Transactions 39:5, pages 1441-1446.
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Brice Korkmaz, Marshall S. Horwitz, Dieter E. Jenne & Francis Gauthier. (2010) Neutrophil Elastase, Proteinase 3, and Cathepsin G as Therapeutic Targets in Human Diseases. Pharmacological Reviews 62:4, pages 726-759.
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Charlie Strange & Sabina Janciauskiene. 2010. Molecular Basis of Pulmonary Disease. Molecular Basis of Pulmonary Disease 209 224 .
Uros V. Djekic, Amit Gaggar & Nathaniel M. Weathington. (2009) Attacking the multi-tiered proteolytic pathology of COPD: New insights from basic and translational studies. Pharmacology & Therapeutics 121:2, pages 132-146.
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Andrew Churg, Manuel Cosio & Joanne L. Wright. (2008) Mechanisms of cigarette smoke-induced COPD: insights from animal models. American Journal of Physiology-Lung Cellular and Molecular Physiology 294:4, pages L612-L631.
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Thierry Moreau, K?vin Baranger, S?bastien Dad?Sandrine Dallet-Choisy, Nicolas Guyot & Marie-Louise Zani. (2008) Multifaceted roles of human elafin and secretory leukocyte proteinase inhibitor (SLPI), two serine protease inhibitors of the chelonianin family. Biochimie 90:2, pages 284-295.
Crossref
Alice M. Wood & Robert A. Stockley. (2007) Alpha One Antitrypsin Deficiency: From Gene to Treatment. Respiration 74:5, pages 481-492.
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