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REVIEW ARTICLES

Defining Disease Modification in Chronic Obstructive Pulmonary Disease

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Pages 211-225 | Published online: 18 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Jane S Watson, Rachel E Jordan, Lucy Gardiner, Peymane Adab & Kate Jolly. (2023) A Systematic Review of the Effectiveness of Interventions to Promote Referral; Adherence; and Uptake of Pulmonary Rehabilitation for Patients with Chronic Obstructive Pulmonary Disease. International Journal of Chronic Obstructive Pulmonary Disease 18, pages 1637-1654.
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Wen-Chien Cheng, Biing-Ru Wu, Wei-Chih Liao, Chih-Yu Chen, Wei-Chun Chen, Te-Chun Hsia, Chih-Yen Tu, Chia-Hung Chen & Wu-Huei Hsu. (2020) When to Use Initial Triple Therapy in COPD: Adding a LAMA to ICS/LABA by Clinically Important Deterioration Assessment. International Journal of Chronic Obstructive Pulmonary Disease 15, pages 3375-3384.
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Kenneth R Chapman, Joanna Chorostowska-Wynimko, A Rembert Koczulla, Ilaria Ferrarotti & Noel G McElvaney. (2018) Alpha 1 antitrypsin to treat lung disease in alpha 1 antitrypsin deficiency: recent developments and clinical implications. International Journal of Chronic Obstructive Pulmonary Disease 13, pages 419-432.
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Joanna Chorostowska-Wynimko. (2016) Disease Modification in Emphysema Related to Alpha-1 Antitrypsin Deficiency. COPD: Journal of Chronic Obstructive Pulmonary Disease 13:6, pages 807-815.
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Stephen I Rennard, Shawn X Sun, Stavros Tourkodimitris, Paul Rowe, Udo M Goehring, Dirk Bredenbröker & Peter M A Calverley. (2014) Roflumilast and dyspnea in patients with moderate to very severe chronic obstructive pulmonary disease: a pooled analysis of four clinical trials. International Journal of Chronic Obstructive Pulmonary Disease 9, pages 657-673.
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Richard L. ZuWallack & Linda Nici. (2012) Modifying the Course of Chronic Obstructive Pulmonary Disease: Looking Beyond the FEV1. COPD: Journal of Chronic Obstructive Pulmonary Disease 9:6, pages 637-648.
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Claus Vogelmeier, Teresita O. Aquino, Christopher D. O'Brien, John Perrett & Kulasiri A. Gunawardena. (2012) A Randomised, Placebo-Controlled, Dose-Finding Study Of AZD9668, An Oral Inhibitor of Neutrophil Elastase, in Patients with Chronic Obstructive Pulmonary Disease Treated with Tiotropium. COPD: Journal of Chronic Obstructive Pulmonary Disease 9:2, pages 111-120.
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Christopher KM Hui & Kian F Chung. (2011) Indacaterol: pharmacologic profile, efficacy and safety in the treatment of adults with COPD. Expert Review of Respiratory Medicine 5:1, pages 9-16.
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Articles from other publishers (18)

Alexandros Panagiotopoulos, Eleni Kapsia, Ioannis Michelakis, John Boletis, Smaragdi Marinaki, Petros P Sfikakis & Maria G Tektonidou. (2023) Disease modification achievement in patients with lupus nephritis in a real-life setting: mission impossible?. RMD Open 9:2, pages e003158.
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Sheila Seleri Assunção, Reisa A. Sperling, Craig Ritchie, Diana R. Kerwin, Paul S. Aisen, Claire Lansdall, Alireza Atri & Jeffrey Cummings. (2022) Meaningful benefits: a framework to assess disease-modifying therapies in preclinical and early Alzheimer’s disease. Alzheimer's Research & Therapy 14:1.
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Ronald van Vollenhoven, Anca D Askanase, Andrew S Bomback, Ian N Bruce, Angela Carroll, Maria Dall'Era, Mark Daniels, Roger A Levy, Andreas Schwarting, Holly A Quasny, Murray B Urowitz, Ming-Hui Zhao & Richard Furie. (2022) Conceptual framework for defining disease modification in systemic lupus erythematosus: a call for formal criteria. Lupus Science & Medicine 9:1, pages e000634.
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Yuki Abe, Masaru Suzuki, Hironi Makita, Hirokazu Kimura, Kaoruko Shimizu, Satoshi Konno & Masaharu Nishimura. (2021) One‐year clinically important deterioration and long‐term clinical course in Japanese patients with COPD: a multicenter observational cohort study. BMC Pulmonary Medicine 21:1.
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Igor Barjaktarevic & Marc Miravitlles. (2021) Alpha-1 antitrypsin (AAT) augmentation therapy in individuals with the PI*MZ genotype: a pro/con debate on a working hypothesis. BMC Pulmonary Medicine 21:1.
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Klaus F. Rabe, David M. G. Halpin, MeiLan K. Han, Marc Miravitlles, Dave Singh, Lars Grönke, Florian Voß & Fernando J. Martinez. (2020) Composite endpoints in COPD: clinically important deterioration in the UPLIFT trial. Respiratory Research 21:1.
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Dave Singh, Gerard J. Criner, Ian Naya, Paul W. Jones, Lee Tombs, David A. Lipson & MeiLan K. Han. (2020) Measuring disease activity in COPD: is clinically important deterioration the answer?. Respiratory Research 21:1.
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Gabriel Thabut & Luciano Corda. (2018) Epidemiology, Diagnosis and Available Treatment for Alpha 1 Antitrypsin Deficiency-related Emphysema in Europe. European Respiratory & Pulmonary Diseases 4:1, pages 25.
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Amber L. Martin, Jessica Marvel, Kyle Fahrbach, Sarah M. Cadarette, Teresa K. Wilcox & James F. Donohue. (2016) The association of lung function and St. George's respiratory questionnaire with exacerbations in COPD: a systematic literature review and regression analysis. Respiratory Research 17:1.
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Mia Cahill. (2016) Modifying Alpha-1 Antitrypsin Deficiency-Related Emphysema: From Evidence to Practice. EMJ Respiratory, pages 35-42.
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Juliana Maria de Sousa Pinto, Ana Martín-Nogueras & Marilyn Nations. (2014) Illness experiences of persons with chronic obstructive pulmonary disease: self-perceived efficacy of home-based pulmonary rehabilitation. Cadernos de Saúde Pública 30:6, pages 1270-1280.
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Fernanda Dultra Dias, Evelim Leal de Freitas Dantas Gomes, Roberto Stirbulov, Vera Lúcia Santos Alves & Dirceu Costa. (2014) Assessment of body composition, functional capacity and pulmonary function in patients with Chronic Obstructive Pulmonary Disease. Fisioterapia e Pesquisa 21:1, pages 10-15.
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Sabin Oana & Jayanta Mukherji. 2014. Neurologic Aspects of Systemic Disease Part I. Neurologic Aspects of Systemic Disease Part I 273 288 .
Karima A. Abd EL Khalek, Magda Y. EL Seify, Omneya I. Youssef & Mona M. Badr. (2012) Diagnostic Value of Exhaled Carbon Monoxide as an Early Marker of Exacerbation in Children with Chronic Lung Diseases. ISRN Pediatrics 2012, pages 1-4.
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Claus Vogelmeier, Teresita O. Aquino, Christopher D. O'Brien, John Perrett & Kulasiri A. Gunawardena. (2012) A Randomised, Placebo-Controlled, Dose-Finding Study Of AZD9668, An Oral Inhibitor of Neutrophil Elastase, in Patients with Chronic Obstructive Pulmonary Disease Treated with Tiotropium. COPD: Journal of Chronic Obstructive Pulmonary Disease, pages 140924102835001.
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Toru Oga, Mitsuhiro Tsukino, Takashi Hajiro, Akihiko Ikeda & Koichi Nishimura. (2012) Analysis of longitudinal changes in dyspnea of patients with chronic obstructive pulmonary disease: an observational study. Respiratory Research 13:1, pages 85.
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Jan Stolk, Brendan G. Cooper, Berend Stoel, Alexis Rames, Olga Rutman, Sherif Soliman & Robert Stockley. (2010) Retinoid treatment of Emphysema in Patients on the Alpha-1 International Registry. The REPAIR study: study design, methodology and quality control of study assessments. Therapeutic Advances in Respiratory Disease 4:6, pages 319-332.
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Toru Oga, Mitsuhiro Tsukino, Takashi Hajiro, Akihiko Ikeda, Hiroshi Koyama, Michiaki Mishima, Kazuo Chin & Koichi Nishimura. (2010) Multidimensional Analyses of Long-Term Clinical Courses of Asthma and Chronic Obstructive Pulmonary Disease. Allergology International 59:3, pages 257-265.
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