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RNA Biology Volume 11, 2014 - Issue 10
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RESEARCH PAPERS

The C-terminal RNA binding motif of HuR is a multi-functional domain leading to HuR oligomerization and binding to U-rich RNA targets

Rafael M ScheibaInstituto de Bioquímica Vegetal y Fotosíntesis; cicCartuja; Sevilla, Spain
,
Alain Ibáñez de OpakuaStructural Biology Unit; CIC bioGUNE; Derio, Spain
,
Antonio Díaz-QuintanaInstituto de Bioquímica Vegetal y Fotosíntesis; cicCartuja; Sevilla, Spain
,
Isabel Cruz-GallardoInstituto de Bioquímica Vegetal y Fotosíntesis; cicCartuja; Sevilla, Spain
,
Luis A Martínez-CruzStructural Biology Unit; CIC bioGUNE; Derio, Spain
,
María L Martínez-ChantarMetabolomics Unit; CIC bioGUNE; Derio; Spain; CIC bioGUNE; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd); Technology Park of Bizkaia; Derio, Bizkaia, Spain;Department of Biochemistry and Molecular Biology; University of the Basque Country UPV/EHU Leioa; Bizkaia, Spain
,
Francisco J BlancoStructural Biology Unit; CIC bioGUNE; Derio, Spain;IKERBASQUE; Basque Foundation for Science; Bilbao, Spain
&
Irene Díaz-MorenoInstituto de Bioquímica Vegetal y Fotosíntesis; cicCartuja; Sevilla, SpainCorrespondence[email protected]
 show all
Pages 1250-1261 | Received 20 Sep 2014, Accepted 20 Sep 2014, Published online: 27 Jan 2015

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Ankita Agarwal, Suresh Alagar, Shri Kant & Ranjit Prasad Bahadur. (2023) Molecular insights into binding dynamics of tandem RNA recognition motifs (tRRMs) of human antigen R (HuR) with mRNA and the effect of point mutations in impaired HuR-mRNA recognition. Journal of Biomolecular Structure and Dynamics 41:11, pages 4830-4846.
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Kotb Abdelmohsen, Amaresh C. Panda, Rachel Munk, Ioannis Grammatikakis, Dawood B. Dudekula, Supriyo De, Jiyoung Kim, Ji Heon Noh, Kyoung Mi Kim, Jennifer L. Martindale & Myriam Gorospe. (2017) Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1. RNA Biology 14:3, pages 361-369.
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Shan Chang, Da-Wei Zhang, Lei Xu, Hua Wan, Ting-Jun Hou & Ren Kong. (2016) Exploring the molecular basis of RNA recognition by the dimeric RNA-binding protein via molecular simulation methods. RNA Biology 13:11, pages 1133-1143.
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Cecilia Osera, Jennifer L Martindale, Marialaura Amadio, Jiyoung Kim, Xiaoling Yang, Christopher A Moad, Fred E Indig, Stefano Govoni, Kotb Abdelmohsen, Myriam Gorospe & Alessia Pascale. (2015) Induction of VEGFA mRNA translation by CoCl2 mediated by HuR. RNA Biology 12:10, pages 1121-1130.
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Abhishek Guha, Saboora Waris, Louis B. Nabors, Natalia Filippova, Myriam Gorospe, Thaddaeus Kwan & Peter H. King. (2022) The versatile role of HuR in Glioblastoma and its potential as a therapeutic target for a multi-pronged attack. Advanced Drug Delivery Reviews 181, pages 114082.
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Rajeswari Raguraman, Santny Shanmugarama, Meghna Mehta, Jo Elle Peterson, Yan D. Zhao, Anupama Munshi & Rajagopal Ramesh. (2022) Drug delivery approaches for HuR-targeted therapy for lung cancer. Advanced Drug Delivery Reviews 180, pages 114068.
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Yueshuang Ke, Xueping Lv, Xingyue Fu, Jing Zhang, Ameer Ali Bohio, Xianlu Zeng, Wenjing Hao, Ruoxi Wang, Istvan Boldogh & Xueqing Ba. (2020) Poly(ADP-ribosyl)ation enhances HuR oligomerization and contributes to pro-inflammatory gene mRNA stabilization. Cellular and Molecular Life Sciences 78:4, pages 1817-1835.
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Ravi Kumar, Dipak Kumar Poria & Partho Sarothi Ray. (2021) RNA-binding proteins La and HuR cooperatively modulate translation repression of PDCD4 mRNA. Journal of Biological Chemistry 296, pages 100154.
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Xiaoqing Song, Xin Shi, Wenjuan Li, Fa Zhang & Zhonglin Cai. (2020) The RNA-Binding Protein HuR in Digestive System Tumors. BioMed Research International 2020, pages 1-7.
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Jesse R. Poganik, Alexandra K. Van Hall‐Beauvais, Marcus J. C. Long, Michael T. Disare, Yi Zhao & Yimon Aye. (2020) The mRNA‐Binding Protein HuR Is a Kinetically‐Privileged Electrophile Sensor. Helvetica Chimica Acta 103:5.
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H Zhou, A G Telonis, Y Jing, N L Xia, L Biederman, M Jimbo, F Blanco, E Londin, J R Brody & I Rigoutsos. (2016) GPRC5A is a potential oncogene in pancreatic ductal adenocarcinoma cells that is upregulated by gemcitabine with help from HuR. Cell Death & Disease 7:7, pages e2294-e2294.
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Zhonghua Wang, Akash Bhattacharya & Dmitri N. Ivanov. (2015) Identification of Small-Molecule Inhibitors of the HuR/RNA Interaction Using a Fluorescence Polarization Screening Assay Followed by NMR Validation. PLOS ONE 10:9, pages e0138780.
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