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Review

The modified base isopentenyladenosine and its derivatives in tRNA

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Pages 1197-1208 | Received 15 Dec 2016, Accepted 08 Feb 2017, Published online: 17 Mar 2017

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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
Ruth I.C. Glasgow, Albert Z. Lim, Thomas J. Nicholls, Robert McFarland, Robert W. Taylor & Monika Oláhová. 2020. The Human Mitochondrial Genome. The Human Mitochondrial Genome 375 409 .
Bohdan Ostash & Maria Anisimova. 2020. Statistical Modelling and Machine Learning Principles for Bioinformatics Techniques, Tools, and Applications. Statistical Modelling and Machine Learning Principles for Bioinformatics Techniques, Tools, and Applications 213 288 .
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Crossref
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Crossref
Shree P. Thapa, Edward W. DavisIIII, Qingyang Lyu, Alexandra J. WeisbergDanielle M. Stevens, Christopher R. Clarke, Gitta Coaker & Jeff H. Chang. (2019) The Evolution, Ecology, and Mechanisms of Infection by Gram-Positive, Plant-Associated Bacteria. Annual Review of Phytopathology 57:1, pages 341-365.
Crossref
Milton H. SaierJr.Jr.. (2019) Understanding the Genetic Code. Journal of Bacteriology 201:15.
Crossref
Oksana Koshla, Oleksandr Yushchuk, Iryna Ostash, Yuriy Dacyuk, Maksym Myronovskyi, Gunilla Jäger, Roderich D. Süssmuth, Andriy Luzhetskyy, Anders Byström, Leif A. Kirsebom & Bohdan Ostash. (2019) Gene miaA for post‐transcriptional modification of tRNA XXA is important for morphological and metabolic differentiation in Streptomyces . Molecular Microbiology 112:1, pages 249-265.
Crossref
Y. Chen, B. Bai, H. Yan, F. Wen, D. Qin, G. Jander, Q. Xia & G. Wang. (2019) Systemic disruption of the homeostasis of transfer RNA isopentenyltransferase causes growth and development abnormalities in Bombyx mori . Insect Molecular Biology 28:3, pages 380-391.
Crossref
A. Maxwell Burroughs, Margaret E. Glasner, Kevin P. Barry, Erika A. Taylor & L. Aravind. (2019) Oxidative opening of the aromatic ring: Tracing the natural history of a large superfamily of dioxygenase domains and their relatives. Journal of Biological Chemistry 294:26, pages 10211-10235.
Crossref
Toshiki Takenouchi, Fan‐Yan Wei, Hisato Suzuki, Tomoko Uehara, Takao Takahashi, Yasushi Okazaki, Kenjiro Kosaki & Kazuhito Tomizawa. (2019) Noninvasive diagnosis of TRIT1 ‐related mitochondrial disorder by measuring i 6 A37 and ms 2 i 6 A37 modifications in tRNAs from blood and urine samples . American Journal of Medical Genetics Part A.
Crossref
Megan M. Aoki, Mark Seegobin, Anna Kisiala, Adam Noble, Craig Brunetti & R. J. Neil Emery. (2019) Phytohormone metabolism in human cells: Cytokinins are taken up and interconverted in HeLa cell culture. FASEB BioAdvances 1:5, pages 320-331.
Crossref
Martin Müller, Carine Legrand, Francesca Tuorto, Vincent P Kelly, Yaser Atlasi, Frank Lyko & Ann E Ehrenhofer-Murray. (2019) Queuine links translational control in eukaryotes to a micronutrient from bacteria. Nucleic Acids Research 47:7, pages 3711-3727.
Crossref
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Crossref
Hiroyuki Hori. (2019) Regulatory Factors for tRNA Modifications in Extreme- Thermophilic Bacterium Thermus thermophilus. Frontiers in Genetics 10.
Crossref
Leticia Pollo-Oliveira & Valérie de Crécy-Lagard. (2018) Can Protein Expression Be Regulated by Modulation of tRNA Modification Profiles?. Biochemistry 58:5, pages 355-362.
Crossref
Yuliia Sehin, Oksana Koshla, Yuriy Dacyuk, Ruoxia Zhao, Robert Ross, Maksym Myronovskyi, Patrick A. Limbach, Andriy Luzhetskyy, Suzanne Walker, Victor Fedorenko & Bohdan Ostash. (2019) Gene ssfg_01967 (miaB) for tRNA modification influences morphogenesis and moenomycin biosynthesis in Streptomyces ghanaensis ATCC14672. Microbiology 165:2, pages 233-245.
Crossref
Navanath M. Kumbhar & Janhavi S. Gopal. (2019) Structural significance of hypermodified nucleoside 5-carboxymethylaminomethyluridine (cmnm5U) from ‘wobble’ (34th) position of mitochondrial tRNAs: Molecular modeling and Markov state model studies. Journal of Molecular Graphics and Modelling 86, pages 66-83.
Crossref
José Pedro Friedmann Angeli & Marcus Conrad. (2018) Selenium and GPX4, a vital symbiosis. Free Radical Biology and Medicine 127, pages 153-159.
Crossref
Hiroyuki Hori, Takuya Kawamura, Takako Awai, Anna Ochi, Ryota Yamagami, Chie Tomikawa & Akira Hirata. (2018) Transfer RNA Modification Enzymes from Thermophiles and Their Modified Nucleosides in tRNA. Microorganisms 6:4, pages 110.
Crossref
Mark Seegobin, Anna Kisiala, Adam Noble, David Kaplan, Craig Brunetti & R. J. Neil Emery. (2018) Canis familiaris tissues are characterized by different profiles of cytokinins typical of the tRNA degradation pathway . The FASEB Journal 32:12, pages 6575-6581.
Crossref
Isao Masuda, Ryuichi Takase, Ryuma Matsubara, Mellie June Paulines, Howard Gamper, Patrick A Limbach & Ya-Ming Hou. (2018) Selective terminal methylation of a tRNA wobble base. Nucleic Acids Research 46:7, pages e37-e37.
Crossref