Advanced search
Publication Cover
RNA Biology Volume 14, 2017 - Issue 9
Submit an article Journal homepage
4,104
Views
46
CrossRef citations to date
0
Altmetric
Review

A fly view on the roles and mechanisms of the m6A mRNA modification and its players

Tina LenceLaboratory of RNA Epigenetics, Institute of Molecular Biology (IMB), Mainz, Germany
,
Matthias SollerSchool of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham, UKORCID Iconhttp://orcid.org/0000-0003-3844-0258
ORCID Icon &
Jean-Yves RoignantLaboratory of RNA Epigenetics, Institute of Molecular Biology (IMB), Mainz, GermanyCorrespondence[email protected]
Pages 1232-1240 | Received 20 Dec 2016, Accepted 10 Mar 2017, Published online: 27 Apr 2017

Citations (46)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Yuanyuan Zhao, Jinzhu Meng, Xingchao Song & Qingming An. (2023) m6A mRNA Methylation Analysis Provides Novel Insights into Pigmentation in Sheep Skin. Epigenetics 18:1.
Read now
Mark Helm. (2017) Editorial: RNA modifications – what to read first?. RNA Biology 14:9, pages 1087-1088.
Read now

Articles from other publishers (44)

Lijiao Sun, Xin Chen, Sai Zhu, Jianan Wang, Shaoxi Diao, Jinyu Liu, Jinjin Xu, Xiaofeng Li, Yingyin Sun, Cheng Huang, Xiaoming Meng, Xiongwen Lv & Jun Li. (2024) Decoding m6A mRNA methylation by reader proteins in liver diseases. Genes & Diseases 11:2, pages 711-726.
Crossref
Jia Huang, Fan Zhou, Huanchan Zhou, Xiaoqi Zheng, Zhengyi Huo, Meng Yang, Zihe Xu, Runzhou Liu, Luoluo Wang & Xiaoyun Wang. (2023) Systematic assessment of transcriptomic and metabolic reprogramming by blue light exposure coupled with aging. PNAS Nexus 2:12.
Crossref
Sirui Liang, Yanxi Zhao, Junru Jin, Jianbo Qiao, Ding Wang, Yu Wang & Leyi Wei. (2023) Rm-LR: A long-range-based deep learning model for predicting multiple types of RNA modifications. Computers in Biology and Medicine 164, pages 107238.
Crossref
Guoying Wang, Xin Ni, Jintian Wang & Ming Dai. (2023) METTL3-mediated m6A methylation of PYGB facilitates pancreatic ductal adenocarcinoma progression through the activation of NF-κB signaling. Pathology - Research and Practice 248, pages 154645.
Crossref
Yaoyu Jiao & Subba Reddy Palli. (2023) N6-adenosine (m6A) mRNA methylation is required for Tribolium castaneum development and reproduction. Insect Biochemistry and Molecular Biology 159, pages 103985.
Crossref
Yu Zhang, Yang Zhou, Dongqi Kan, Yunhong Yang, Jing Shen, Cui Han, Xiaojie Liu & Jiaxin Yang. (2023) m6A-mediated nonhomologous end joining (NHEJ) pathway regulates senescence in Brachionus plicatilis (Rotifera). Archives of Gerontology and Geriatrics 111, pages 104994.
Crossref
Daniel Wilinski & Monica Dus. (2023) N6-adenosine methylation controls the translation of insulin mRNA. Nature Structural & Molecular Biology.
Crossref
Li-Bin He, Hui-Yu Luo & Le-Yun Zheng. (2023) Atmosphere and room temperature plasma alters the m6A methylome profiles and regulates gene expression associated with color mutation in clownfish (Amphiprion ocellaris). Frontiers in Marine Science 10.
Crossref
Yiguo Lei, Qingtian Zeng, Guangsheng Tan, Zhixiang Yuan, Ning Zhang, Jianyong Liu & Wei Wang. (2023) A first glimpse into the m6A modification machinery of shrimp: Genomic features, expression patterns and potential roles in molting regulation. Aquaculture Reports 29, pages 101493.
Crossref
Lin Li, Jing Chen & Yun-Qing Li. (2023) The Downregulation of Opioid Receptors and Neuropathic Pain. International Journal of Molecular Sciences 24:6, pages 5981.
Crossref
Dipayan Bose, Xiang Lin, Le Gao, Zhi Wei, Yonggang Pei & Erle S. Robertson. (2023) Attenuation of IFN signaling due to m6A modification of the host epitranscriptome promotes EBV lytic reactivation. Journal of Biomedical Science 30:1.
Crossref
Lisa-Marie Appel, Johannes Benedum, Magdalena Engl, Sebastian Platzer, Alexander Schleiffer, Xué Strobl & Dea Slade. (2023) SPOC domain proteins in health and disease. Genes & Development 37:5-6, pages 140-170.
Crossref
Ina Anreiter, Yuan W. Tian & Matthias Soller. (2022) The cap epitranscriptome: Early directions to a complex life as mRNA. BioEssays 45:3.
Crossref
Yael Dagan, Yarden Yesharim, Ashley R Bonneau, Tamar Frankovits, Schraga Schwartz, Peter W Reddien & Omri Wurtzel. (2022) m6A is required for resolving progenitor identity during planarian stem cell differentiation . The EMBO Journal 41:21.
Crossref
Nadiya Khyzha, Steven Henikoff & Kami Ahmad. (2022) Profiling RNA at chromatin targets in situ by antibody-targeted tagmentation. Nature Methods 19:11, pages 1383-1392.
Crossref
Alexandra E. Perlegos, Emily J. Shields, Hui Shen, Kathy Fange Liu & Nancy M. Bonini. (2022) Mettl3-dependent m6A modification attenuates the brain stress response in Drosophila. Nature Communications 13:1.
Crossref
Yang Zheng, Yunqi Li, Xianwen Ran, Di Wang, Xianghui Zheng, Maomao Zhang, Bo Yu, Yong Sun & Jian Wu. (2022) Mettl14 mediates the inflammatory response of macrophages in atherosclerosis through the NF-κB/IL-6 signaling pathway. Cellular and Molecular Life Sciences 79:6.
Crossref
Congshan Liu, Jianping Cao, Haobing Zhang, Jiatong Wu & Jianhai Yin. (2022) Profiling of Transcriptome-Wide N6-Methyladenosine (m6A) Modifications and Identifying m6A Associated Regulation in Sperm Tail Formation in Anopheles sinensis. International Journal of Molecular Sciences 23:9, pages 4630.
Crossref
Congshan Liu, Jianping Cao, Haobing Zhang & Jianhai Yin. (2022) Evolutionary History of RNA Modifications at N6-Adenosine Originating from the R-M System in Eukaryotes and Prokaryotes. Biology 11:2, pages 214.
Crossref
Mengqi Chang, Zihao Wang, Jun Gao, Chengxian Yang, Ming Feng, Yamei Niu, Wei-Min Tong, Xinjie Bao & Renzhi Wang. (2022) METTL3-mediated RNA m6A Hypermethylation Promotes Tumorigenesis and GH Secretion of Pituitary Somatotroph Adenomas. The Journal of Clinical Endocrinology & Metabolism 107:1, pages 136-149.
Crossref
Yuri Motorin & Mark Helm. (2021) RNA nucleotide methylation: 2021 update . WIREs RNA 13:1.
Crossref
Shao-Yen Kao, Elena Nikonova, Sabrina Chaabane, Albiona Sabani, Alexandra Martitz, Anja Wittner, Jakob Heemken, Tobias Straub & Maria L. Spletter. (2021) A Candidate RNAi Screen Reveals Diverse RNA-Binding Protein Phenotypes in Drosophila Flight Muscle. Cells 10:10, pages 2505.
Crossref
Stephanie Oerum, Vincent Meynier, Marjorie Catala & Carine Tisné. (2021) A comprehensive review of m6A/m6Am RNA methyltransferase structures. Nucleic Acids Research 49:13, pages 7239-7255.
Crossref
Ziqian Shen, Abby Hinson, Richard A. Miller & Gonzalo G. Garcia. (2021) Cap‐independent translation: A shared mechanism for lifespan extension by rapamycin, acarbose, and 17α‐estradiol. Aging Cell 20:5.
Crossref
D. A. Novikov, A. P. Beletsky & P. M. Kolosov. (2021) The Putative Role of m6A-RNA Methylation in Memory Consolidation. Neurochemical Journal 15:2, pages 103-113.
Crossref
Hong-Wen TangJui-Hsia WengWen Xing Lee, Yanhui HuLei Gu, Sungyun ChoGina Lee, Richard BinariCathleen LiMin En ChengAh-Ram Kim, Jun XuZhangfei ShenChiwei XuJohn M. Asara, John Blenis & Norbert Perrimon. (2021) mTORC1-chaperonin CCT signaling regulates m 6 A RNA methylation to suppress autophagy . Proceedings of the National Academy of Sciences 118:10.
Crossref
Lorane Le Franc, Benoit Bernay, Bruno Petton, Marc Since, Pascal Favrel & Guillaume Rivière. (2020) A functional m 6 A‐RNA methylation pathway in the oyster Crassostrea gigas assumes epitranscriptomic regulation of lophotrochozoan development . The FEBS Journal 288:5, pages 1696-1711.
Crossref
Bi-Xin Zheng, Ayma Malik, Ming Xiong, Alex Bekker & Yuan-Xiang Tao. (2021) Nerve trauma-caused downregulation of opioid receptors in primary afferent neurons: Molecular mechanisms and potential managements. Experimental Neurology 337, pages 113572.
Crossref
Stephan Werner, Aurellia Galliot, Florian Pichot, Thomas Kemmer, Virginie Marchand, Maksim V Sednev, Tina Lence, Jean-Yves Roignant, Julian König, Claudia Höbartner, Yuri Motorin, Andreas Hildebrandt & Mark Helm. (2021) NOseq: amplicon sequencing evaluation method for RNA m6A sites after chemical deamination. Nucleic Acids Research 49:4, pages e23-e23.
Crossref
Lina Worpenberg, Chiara Paolantoni, Sara Longhi, Miriam M Mulorz, Tina Lence, Hans‐Hermann Wessels, Erik Dassi, Giuseppe Aiello, F X Reymond Sutandy, Marion Scheibe, Raghu R Edupuganti, Anke Busch, Martin M Möckel, Michiel Vermeulen, Falk Butter, Julian König, Michela Notarangelo, Uwe Ohler, Christoph Dieterich, Alessandro Quattrone, Alessia Soldano & Jean‐Yves Roignant. (2021) Ythdf is a N6‐methyladenosine reader that modulates Fmr1 target mRNA selection and restricts axonal growth in Drosophila . The EMBO Journal 40:4.
Crossref
Antonio L. Rockwell & Cintia F. Hongay. (2020) Dm Ime4 depletion affects permeability barrier and Chic function in Drosophila spermatogenesis. Mechanisms of Development 164, pages 103650.
Crossref
Amy Tsurumi & Willis X. Li. (2020) Aging mechanisms—A perspective mostly from Drosophila . Advanced Genetics 1:1.
Crossref
Jessica Leismann, Mariangela Spagnuolo, Mihika Pradhan, Ludivine Wacheul, Minh Anh Vu, Michael Musheev, Pablo Mier, Miguel A Andrade‐Navarro, Marc Graille, Christof Niehrs, Denis LJ Lafontaine & Jean‐Yves Roignant. (2020) The 18S ribosomal RNA m 6 A methyltransferase Mettl5 is required for normal walking behavior in Drosophila . EMBO reports 21:7.
Crossref
Antonio L. Rockwell & Cintia F. Hongay. (2019) The m6A Dynamics of Profilin in Neurogenesis. Frontiers in Genetics 10.
Crossref
Adam M. Heck & Carol J. Wilusz. (2019) Small changes, big implications: The impact of m6A RNA methylation on gene expression in pluripotency and development. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1862:9, pages 194402.
Crossref
Qingbai Liu, Meng Li, Lei Jiang, Rui Jiang & Bin Fu. (2019) METTL3 promotes experimental osteoarthritis development by regulating inflammatory response and apoptosis in chondrocyte. Biochemical and Biophysical Research Communications 516:1, pages 22-27.
Crossref
Cody M. Palumbo & Peter A. Beal. (2019) Nucleoside analogs in the study of the epitranscriptome. Methods 156, pages 46-52.
Crossref
Dario L. Balacco & Matthias Soller. (2018) The m 6 A Writer: Rise of a Machine for Growing Tasks . Biochemistry 58:5, pages 363-378.
Crossref
Lina Worpenberg, Tobias Jakobi, Christoph Dieterich & Jean-Yves Roignant. 2019. Epitranscriptomics. Epitranscriptomics 89 106 .
Estefanía Sánchez-Vásquez, Nagif Alata Jimenez, Nicolás A. Vázquez & Pablo H. Strobl-Mazzulla. (2018) Emerging role of dynamic RNA modifications during animal development. Mechanisms of Development 154, pages 24-32.
Crossref
Margarita T. Angelova, Dilyana G. Dimitrova, Nadja Dinges, Tina Lence, Lina Worpenberg, Clément Carré & Jean-Yves Roignant. (2018) The Emerging Field of Epitranscriptomics in Neurodevelopmental and Neuronal Disorders. Frontiers in Bioengineering and Biotechnology 6.
Crossref
Y. Jung & D. Goldman. (2018) Role of RNA modifications in brain and behavior. Genes, Brain and Behavior 17:3, pages e12444.
Crossref
Philip Knuckles, Tina Lence, Irmgard U. Haussmann, Dominik Jacob, Nastasja Kreim, Sarah H. Carl, Irene Masiello, Tina Hares, Rodrigo Villaseñor, Daniel Hess, Miguel A. Andrade-Navarro, Marco Biggiogera, Mark Helm, Matthias Soller, Marc Bühler & Jean-Yves Roignant. (2018) Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m 6 A machinery component Wtap/Fl(2)d . Genes & Development 32:5-6, pages 415-429.
Crossref
Jean-Yves Roignant & Matthias Soller. (2017) m 6 A in mRNA: An Ancient Mechanism for Fine-Tuning Gene Expression. Trends in Genetics 33:6, pages 380-390.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.