3,454
Views
75
CrossRef citations to date
0
Altmetric
TRANSLATIONAL RESEARCH PAPER

Resistance to sunitinib in renal clear cell carcinoma results from sequestration in lysosomes and inhibition of the autophagic flux

, , , , , , , , , , , , & show all
Pages 1891-1904 | Received 09 Jan 2015, Accepted 06 Aug 2015, Published online: 27 Oct 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Christopher Montemagno, Anais Hagege, Delphine Borchiellini, Brice Thamphya, Olivia Rastoin, Damien Ambrosetti, Juan Iovanna, Nathalie Rioux-Leclercq, Camillio Porta, Sylvie Negrier, Jean-Marc Ferrero, Emmanuel Chamorey, Gilles Pagès & Maeva Dufies. (2020) Soluble forms of PD-L1 and PD-1 as prognostic and predictive markers of sunitinib efficacy in patients with metastatic clear cell renal cell carcinoma. OncoImmunology 9:1.
Read now

Articles from other publishers (74)

Yunxia Wang, Xiaolin Liu, Luyao Gong, Weihong Ding, Wenjing Hao, Yeheng Peng, Jun Zhang, Weimin Cai & Yuan Gao. (2023) Mechanisms of sunitinib resistance in renal cell carcinoma and associated opportunities for therapeutics. British Journal of Pharmacology 180:23, pages 2937-2955.
Crossref
Libin Yan, Siyue Liu, Guoliang Sun, Beichen Ding, Zhize Wang & Heng Li. (2023) Loss of SETD2‐mediated downregulation of intracellular and exosomal miRNA‐10b determines MAPK pathway activation and multidrug resistance in renal cancer. Molecular Carcinogenesis.
Crossref
Juan Jin, Yuhao Xie, Jin-Shi Zhang, Jing-Quan Wang, Shi-Jie Dai, Wen-fang He, Shou-Ye Li, Charles R. AshbyJr.Jr., Zhe-Sheng Chen & Qiang He. (2023) Sunitinib resistance in renal cell carcinoma: From molecular mechanisms to predictive biomarkers. Drug Resistance Updates 67, pages 100929.
Crossref
Yihui Pan, Xuanxuan Lu, Guannan Shu, Junjie Cen, Jun Lu, Mi Zhou, Kangbo Huang, Jiaqi Dong, Jiaying Li, Haishan Lin, Hongde Song, Quanhui Xu, Hui Han, Zhenhua Chen, Wei Chen, Junhang Luo, Jinhuan Wei & Jiaxing Zhang. (2023) Extracellular Vesicle-Mediated Transfer of LncRNA IGFL2-AS1 Confers Sunitinib Resistance in Renal Cell Carcinoma . Cancer Research 83:1, pages 103-116.
Crossref
Tomas Koltai, Larry Fliegel, Fátima Baltazar, Stephan J. Reshkin, Khalid O. Alfarouk, Rosa Angela Cardone & Julieta Afonso. 2023. pH Deregulation as the Eleventh Hallmark of Cancer. pH Deregulation as the Eleventh Hallmark of Cancer 151 162 .
Bo Jiang, Xiaozhi Zhao, Wei Chen, Wenli Diao, Meng Ding, Haixiang Qin, Binghua Li, Wenmin Cao, Wei Chen, Yao Fu, Kuiqiang He, Jie Gao, Mengxia Chen, Tingsheng Lin, Yongming Deng, Chao Yan & Hongqian Guo. (2022) Lysosomal protein transmembrane 5 promotes lung-specific metastasis by regulating BMPR1A lysosomal degradation. Nature Communications 13:1.
Crossref
P. Mlejnek, J. Havlasek, N. Pastvova, P. Dolezel & K. Dostalova. (2022) Lysosomal sequestration of weak base drugs, lysosomal biogenesis, and cell cycle alteration. Biomedicine & Pharmacotherapy 153, pages 113328.
Crossref
Lucio Dell’Atti, Nicoletta Bianchi & Gianluca Aguiari. (2022) New Therapeutic Interventions for Kidney Carcinoma: Looking to the Future. Cancers 14:15, pages 3616.
Crossref
Jean‐François Gal, Pierre‐Charles Maria, Elisabet Duñach & Uwe J. Meierhenrich. (2022) Evolution of Chemical Research in Nice, Côte d′Azur: From Early Laboratories to the ‘Institut de Chimie de Nice’. ChemPlusChem 87:6.
Crossref
Yien Xiang, Ge Zheng, Jianfeng Zhong, Jiyao Sheng & Hanjiao Qin. (2022) Advances in Renal Cell Carcinoma Drug Resistance Models. Frontiers in Oncology 12.
Crossref
Ying-Hsia Shih, Cheng-Liang Peng, Ping-Fang Chiang & Ming-Jium Shieh. (2022) Dual-Functional Polymeric Micelles Co-Loaded with Antineoplastic Drugs and Tyrosine Kinase Inhibitor for Combination Therapy in Colorectal Cancer. Pharmaceutics 14:4, pages 768.
Crossref
Damien Ambrosetti, Michael Coutts, Charlotte Paoli, Matthieu Durand, Delphine Borchiellini, Christopher Montemagno, Olivia Rastoin, Arnaud Borderie, Renaud Grepin, Nathalie Rioux‐Leclercq, Jean‐Christophe Bernhard, Gilles Pagès & Maeva Dufies. (2021) Cancer‐associated fibroblasts in renal cell carcinoma: implication in prognosis and resistance to anti‐angiogenic therapy. BJU International 129:1, pages 80-92.
Crossref
Marina Pagnuzzi-Boncompagni, Vincent Picco, Valérie Vial, Victor Planas-Bielsa, Ashaina Vandenberghe, Thomas Daubon, Marie-Alix Derieppe, Christopher Montemagno, Jérôme Durivault, Renaud Grépin, Sonia Martial, Jérôme Doyen, Julie Gavard & Gilles Pagès. (2021) Antiangiogenic Compound Axitinib Demonstrates Low Toxicity and Antitumoral Effects against Medulloblastoma. Cancers 14:1, pages 70.
Crossref
Aurore Dumond, Etienne Brachet, Jérôme Durivault, Valérie Vial, Anna K. Puszko, Yves Lepelletier, Christopher Montemagno, Marina Pagnuzzi-Boncompagni, Olivier Hermine, Christiane Garbay, Nathalie Lagarde, Matthieu Montes, Luc Demange, Renaud Grépin & Gilles Pagès. (2021) Neuropilin 1 and Neuropilin 2 gene invalidation or pharmacological inhibition reveals their relevance for the treatment of metastatic renal cell carcinoma. Journal of Experimental & Clinical Cancer Research 40:1.
Crossref
Pablo Álvarez Ballesteros, Jesús Chamorro, María San Román-Gil, Javier Pozas, Victoria Gómez Dos Santos, Álvaro Ruiz Granados, Enrique Grande, Teresa Alonso-Gordoa & Javier Molina-Cerrillo. (2021) Molecular Mechanisms of Resistance to Immunotherapy and Antiangiogenic Treatments in Clear Cell Renal Cell Carcinoma. Cancers 13:23, pages 5981.
Crossref
Ami Rambhia, Rutul D Patel, Kennedy E Okhawere, Talia G Korn & Ketan K Badani. (2021) Immunotherapy for metastatic renal cell carcinoma: A brief history, current trends, and future directions. Urologic Oncology: Seminars and Original Investigations 39:10, pages 664-677.
Crossref
Joaquim Bosch-Barrera, Sara Verdura, José Carlos Ruffinelli, Enric Carcereny, Elia Sais, Elisabet Cuyàs, Ramon Palmero, Eugeni Lopez-Bonet, Alejandro Hernández-Martínez, Gloria Oliveras, Maria Buxó, Angel Izquierdo, Teresa Morán, Ernest Nadal & Javier A. Menendez. (2021) Silibinin Suppresses Tumor Cell-Intrinsic Resistance to Nintedanib and Enhances Its Clinical Activity in Lung Cancer. Cancers 13:16, pages 4168.
Crossref
Domenico Ribatti, Antonio Giovanni Solimando & Francesco Pezzella. (2021) The Anti-VEGF(R) Drug Discovery Legacy: Improving Attrition Rates by Breaking the Vicious Cycle of Angiogenesis in Cancer. Cancers 13:14, pages 3433.
Crossref
Marwa A. Fouad, Mayssoune Y. Zaki, Raghda A. Lotfy & Walaa R. Mahmoud. (2021) Insight on a new indolinone derivative as an orally bioavailable lead compound against renal cell carcinoma. Bioorganic Chemistry 112, pages 104985.
Crossref
Magdalena Rausch, Adriano Rutz, Pierre-Marie Allard, Céline Delucinge-Vivier, Mylène Docquier, Olivier Dormond, Jean-Luc Wolfender & Patrycja Nowak-Sliwinska. (2021) Molecular and Functional Analysis of Sunitinib-Resistance Induction in Human Renal Cell Carcinoma Cells. International Journal of Molecular Sciences 22:12, pages 6467.
Crossref
Aurore Dumond, Christopher Montemagno, Valérie Vial, Renaud Grépin & Gilles Pagès. (2021) Anti-Vascular Endothelial Growth Factor C Antibodies Efficiently Inhibit the Growth of Experimental Clear Cell Renal Cell Carcinomas. Cells 10:5, pages 1222.
Crossref
Ruizhe Mao, Jian Shi, Xuyi Ma & Haiyan Xu. (2021) Hydroxychloroquine Potentiates Apoptosis Induced by PPARα Antagonist in 786-O Clear Cell Renal Cell Carcinoma Cells Associated with Inhibiting Autophagy. PPAR Research 2021, pages 1-14.
Crossref
Kuo-Hao Ho, Yi-Ting Lee, Peng-Hsu Chen, Chwen-Ming Shih, Chia-Hsiung Cheng & Ku-Chung Chen. (2021) Guanabenz Sensitizes Glioblastoma Cells to Sunitinib by Inhibiting GADD34-Mediated Autophagic Signaling. Neurotherapeutics 18:2, pages 1371-1392.
Crossref
Luchao Li, Shuo Zhao, Zhengfang Liu, Nianzhao Zhang, Shuo Pang, Jikai Liu, Cheng Liu & Yidong Fan. (2021) Sunitinib treatment promotes metastasis of drug-resistant renal cell carcinoma via TFE3 signaling pathway. Cell Death & Disease 12:2.
Crossref
Juan Li, Ke Pu, Chunmei Li, Yuping Wang & Yongning Zhou. (2021) A Novel Six-Gene-Based Prognostic Model Predicts Survival and Clinical Risk Score for Gastric Cancer. Frontiers in Genetics 12.
Crossref
Maeva Dufies, Annelies Verbiest, Lindsay S. Cooley, Papa Diogop Ndiaye, Xingkang He, Nicolas Nottet, Wilfried Souleyreau, Anais Hagege, Stephanie Torrino, Julien Parola, Sandy Giuliano, Delphine Borchiellini, Renaud Schiappa, Baharia Mograbi, Jessica Zucman-Rossi, Karim Bensalah, Alain Ravaud, Patrick Auberger, Andréas Bikfalvi, Emmanuel Chamorey, Nathalie Rioux-Leclercq, Nathalie M. Mazure, Benoit Beuselinck, Yihai Cao, Jean Christophe Bernhard, Damien Ambrosetti & Gilles Pagès. (2021) Plk1, upregulated by HIF-2, mediates metastasis and drug resistance of clear cell renal cell carcinoma. Communications Biology 4:1.
Crossref
Ziying Ren, Long Zhang, Wei Ding, Yilang Luo, Zhiqiang Shi, Bikal Shrestha, Xuan Kan, Zhuhua Zhang, Jing Ding, Haojie He & Xuegang Hu. (2021) Development and validation of a novel survival model for head and neck squamous cell carcinoma based on autophagy-related genes. Genomics 113:1, pages 1166-1175.
Crossref
Ninadh M. D’Costa, Matthew R. Lowerison, Peter A. Raven, Zheng Tan, Morgan E. Roberts, Raunak Shrestha, Matthew W. Urban, Cesar U. Monjaras-Avila, Htoo Zarni Oo, Antonio Hurtado-Coll, Claudia Chavez-Munoz & Alan I. So. (2020) Y-box binding protein-1 is crucial in acquired drug resistance development in metastatic clear-cell renal cell carcinoma. Journal of Experimental & Clinical Cancer Research 39:1.
Crossref
Dechao Li, Changfu Li, Yongsheng Chen, Lichen Teng, Yan Cao, Wentao Wang, Hongxin Pan, Yongpeng Xu & Dan Yang. (2020) LncRNA HOTAIR induces sunitinib resistance in renal cancer by acting as a competing endogenous RNA to regulate autophagy of renal cells. Cancer Cell International 20:1.
Crossref
Baicun Li, Jie Yao, Kaiqiang Guo, Fengming He, Kun Chen, Zongxin Lin, Shunzhi Liu, Jiangang Huang, Qiaoqiong Wu, Meijuan Fang, Jinzhang Zeng & Zhen Wu. (2020) Design, synthesis, and biological evaluation of 5-((8-methoxy-2-methylquinolin-4-yl)amino)-1H-indole-2-carbohydrazide derivatives as novel Nur77 modulators. European Journal of Medicinal Chemistry 204, pages 112608.
Crossref
Gong Cheng, Yuenan Liu, Lilong Liu, Hailong Ruan, Qi Cao, Zhengshuai Song, Lin Bao, Tianbo Xu, Zhiyong Xiong, Jingchong Liu, Di Liu, Huageng Liang, Guosong Jiang, Xiong Yang, Hongmei Yang, Ke Chen & Xiaoping Zhang. (2020) LINC00160 mediates sunitinib resistance in renal cell carcinoma via SAA1 that is implicated in STAT3 activation and compound transportation. Aging 12:17, pages 17459-17479.
Crossref
P. Mlejnek, J. Havlasek, N. Pastvova & P. Dolezel. (2020) Can image analysis provide evidence that lysosomal sequestration mediates daunorubicin resistance?. Chemico-Biological Interactions 327, pages 109138.
Crossref
Christopher Montemagno & Gilles Pagès. (2020) Resistance to Anti-angiogenic Therapies: A Mechanism Depending on the Time of Exposure to the Drugs. Frontiers in Cell and Developmental Biology 8.
Crossref
Nazila Fathi Maroufi, Sina Taefehshokr, Mohammad-Reza Rashidi, Nima Taefehshokr, Mahdieh Khoshakhlagh, Alireza Isazadeh, Narmin Mokarizadeh, Behzad Baradaran & Mohammad Nouri. (2020) Vascular mimicry: changing the therapeutic paradigms in cancer. Molecular Biology Reports 47:6, pages 4749-4765.
Crossref
Magdalena Rudzińska, Alessandro Parodi, Valentina D. Maslova, Yuri M. Efremov, Neonila V. Gorokhovets, Vladimir A. Makarov, Vasily A. Popkov, Andrey V. Golovin, Evgeni Y. Zernii & Andrey A. ZamyatninJr.Jr.. (2020) Cysteine Cathepsins Inhibition Affects Their Expression and Human Renal Cancer Cell Phenotype. Cancers 12:5, pages 1310.
Crossref
Junfei Gu, Yong Zhang, Zhenwei Han, Lei Gao, Jinfeng Cui, Yin Sun, Yuanjie Niu, Bosen You, Chi-Ping Huang, Chawnshang Chang, Xiaolu Wang & Shuyuan Yeh. (2020) Targeting the ERβ/Angiopoietin-2/Tie-2 signaling-mediated angiogenesis with the FDA-approved anti-estrogen Faslodex to increase the Sunitinib sensitivity in RCC. Cell Death & Disease 11:5.
Crossref
Judith Jing Wen Wong, Maria Brandal Berstad, Ane Sofie Viset Fremstedal, Kristian Berg, Sebastian Patzke, Vigdis Sørensen, Qian Peng, Pål Kristian Selbo & Anette Weyergang. (2020) Photochemically-Induced Release of Lysosomal Sequestered Sunitinib: Obstacles for Therapeutic Efficacy. Cancers 12:2, pages 417.
Crossref
Lin Cui, Li-Ping Zhao, Jing-Ying Ye, Lei Yang, Yao Huang, Xu-Pin Jiang, Qiong Zhang, Jie-Zhi Jia, Dong-Xia Zhang & Yuesheng Huang. (2020) The Lysosomal Membrane Protein Lamp2 Alleviates Lysosomal Cell Death by Promoting Autophagic Flux in Ischemic Cardiomyocytes. Frontiers in Cell and Developmental Biology 8.
Crossref
Li Liu, Lu Yan, Ning Liao, Wan-Qin Wu & Jun-Ling Shi. (2020) A Review of ULK1-Mediated Autophagy in Drug Resistance of Cancer. Cancers 12:2, pages 352.
Crossref
Nikola Skoupa, Petr Dolezel & Petr Mlejnek. (2020) Lysosomal Fusion: An Efficient Mechanism Increasing Their Sequestration Capacity for Weak Base Drugs without Apparent Lysosomal Biogenesis. Biomolecules 10:1, pages 77.
Crossref
Etienne Brachet, Aurore Dumond, Wang-Qing Liu, Marie Fabre, Mohamed Selkti, Françoise Raynaud, Olivier Hermine, Rachid Benhida, Philippe Belmont, Christiane Garbay, Yves Lepelletier, Cyril Ronco, Gilles Pagès & Luc Demange. (2019) Synthesis, 3D-structure and stability analyses of NRPa-308, a new promising anti-cancer agent. Bioorganic & Medicinal Chemistry Letters 29:24, pages 126710.
Crossref
Shuang Wu, Limin Huang, Rong Shen, Melanie Bernard‑Cacciarella, Pei Zhou, Chaoquan Hu, Melanie Di Benedetto, Anne Janin, Guilhem Bousquet, Hong Li, Zhixu He & He Lu. (2019) Drug resistance‑related sunitinib sequestration in autophagolysosomes of endothelial cells. International Journal of Oncology.
Crossref
Eliska Ruzickova, Nikola Skoupa, Petr Dolezel, Dennis A. Smith & Petr Mlejnek. (2019) The Lysosomal Sequestration of Tyrosine Kinase Inhibitors and Drug Resistance. Biomolecules 9:11, pages 675.
Crossref
Bangbei Wan, Bo Liu, Gang Yu, Yuan Huang & Cai Lv. (2019) Differentially expressed autophagy-related genes are potential prognostic and diagnostic biomarkers in clear-cell renal cell carcinoma. Aging 11:20, pages 9025-9042.
Crossref
Pozas, San Román, Alonso-Gordoa, Pozas, Caracuel, Carrato & Molina-Cerrillo. (2019) Targeting Angiogenesis in Pancreatic Neuroendocrine Tumors: Resistance Mechanisms. International Journal of Molecular Sciences 20:19, pages 4949.
Crossref
Bolin Hou, Gang Wang, Quan Gao, Yanjie Wei, Caining Zhang, Yange Wang, Yuqing Huo, Huaiyi Yang, Xuejun Jiang & Zhijun Xi. (2019) SQSTM1/p62 loss reverses the inhibitory effect of sunitinib on autophagy independent of AMPK signaling. Scientific Reports 9:1.
Crossref
Piotr Wierzbicki, Jakub Klacz, Anna Kotulak‑Chrzaszcz, Agata Wronska, Marcin Stanislawowski, Agnieszka Rybarczyk, Aleksandra Ludziejewska, Zbigniew Kmiec & Marcin Matuszewski. (2019) Prognostic significance of VHL, HIF1A, HIF2A, VEGFA and p53 expression in patients with clear‑cell renal cell carcinoma treated with sunitinib as first‑line treatment. International Journal of Oncology.
Crossref
Qianwei Xing, Ran Li, Aiming Xu, Zhiqiang Qin, Jinyuan Tang, Lei Zhang, Min Tang, Peng Han, Wei Wang, Chao Qin, Mulong Du & Wei Zhang. (2019) Genetic variants in a long noncoding RNA related to Sunitinib Resistance predict risk and survival of patients with renal cell carcinoma. Cancer Medicine 8:6, pages 2886-2896.
Crossref
Kira L. Russell, Carolina Mendonça Gorgulho, Abigail Allen, Marianna Vakaki, Yue Wang, Andrea Facciabene, Daniel Lee, Partha Roy, William J. Buchser, Leonard J. Appleman, Jodi Maranchie, Walter J. Storkus & Michael T. Lotze. (2019) Inhibiting Autophagy in Renal Cell Cancer and the Associated Tumor Endothelium. The Cancer Journal 25:3, pages 165-177.
Crossref
Yann Cormerais, Marina Pagnuzzi‐Boncompagni, Sandra Schrötter, Sandy Giuliano, Eric Tambutté, Hitoshi Endou, Michael F. Wempe, Gilles Pagès, Jacques Pouysségur & Vincent Picco. (2019) Inhibition of the amino‐acid transporter LAT1 demonstrates anti‐neoplastic activity in medulloblastoma. Journal of Cellular and Molecular Medicine 23:4, pages 2711-2718.
Crossref
Zsuzsanna Lichner, Rola Saleeb, Henriett Butz, Qiang Ding, Roy Nofech-Mozes, Sara Riad, Mina Farag, Amir K. Varkouhi, Claudia C. Santos, András Kapus & George M. Yousef. (2018) Sunitinib induces early histomolecular changes in a subset of renal cancer cells that contribute to resistance. The FASEB Journal 33:1, pages 1347-1359.
Crossref
Prakash C. Thakur, Jennifer L. Miller-Ocuin, Khanh Nguyen, Rina Matsuda, Aatur D. Singhi, Herbert J. Zeh & Nathan Bahary. (2018) Inhibition of endoplasmic-reticulum-stress-mediated autophagy enhances the effectiveness of chemotherapeutics on pancreatic cancer. Journal of Translational Medicine 16:1.
Crossref
Lei Zhan, Jun Li & Bing Wei. (2018) Autophagy therapeutics: preclinical basis and initial clinical studies. Cancer Chemotherapy and Pharmacology 82:6, pages 923-934.
Crossref
Valentina Fonsato, Michela De Lena, Stefania Tritta, Alessia Brossa, Ruggero Calvetti, Ciro Tetta, Giovanni Camussi & Benedetta Bussolati. (2018) Human liver stem cell-derived extracellular vesicles enhance cancer stem cell sensitivity to tyrosine kinase inhibitors through Akt/mTOR/PTEN combined modulation. Oncotarget 9:90, pages 36151-36165.
Crossref
Laurel M. Schunselaar, Kim Monkhorst, Vincent van der Noort, Ruud Wijdeven, Dennis Peters, Wilbert Zwart, Jacques Neefjes & Paul Baas. (2018) Trophoblast Glycoprotein is Associated With a Favorable Outcome for Mesothelioma and a Target for Antibody Drug Conjugates. Journal of Thoracic Oncology 13:10, pages 1577-1587.
Crossref
Xiaoqing Ren, Yiting Chen, Haibao Peng, Xiaoling Fang, Xiulei Zhang, Qinyue Chen, Xiaofei Wang, Wuli Yang & Xianyi Sha. (2018) Blocking Autophagic Flux Enhances Iron Oxide Nanoparticle Photothermal Therapeutic Efficiency in Cancer Treatment. ACS Applied Materials & Interfaces 10:33, pages 27701-27711.
Crossref
Jayabal Pandiaraja. (2021) Incidence of Malignancy in the Future?. Indian Journal of Medical and Paediatric Oncology 39:03, pages 420-421.
Crossref
Hamid Marzag, Marwa Zerhouni, Hamza Tachallait, Luc Demange, Guillaume Robert, Khalid Bougrin, Patrick Auberger & Rachid Benhida. (2018) Modular synthesis of new C-aryl-nucleosides and their anti-CML activity. Bioorganic & Medicinal Chemistry Letters 28:10, pages 1931-1936.
Crossref
Helena Polena, Julie Creuzet, Maeva Dufies, Adama Sidibé, Abir Khalil-Mgharbel, Aude Salomon, Alban Deroux, Jean-Louis Quesada, Caroline Roelants, Odile Filhol, Claude Cochet, Ellen Blanc, Céline Ferlay-Segura, Delphine Borchiellini, Jean-Marc Ferrero, Bernard Escudier, Sylvie Négrier, Gilles Pages & Isabelle Vilgrain. (2018) The tyrosine-kinase inhibitor sunitinib targets vascular endothelial (VE)-cadherin: a marker of response to antitumoural treatment in metastatic renal cell carcinoma. British Journal of Cancer 118:9, pages 1179-1188.
Crossref
Yessica Castellanos-Esparza, Shuang Wu, Limin Huang, Catherine Buquet, Rong Shen, Berenice Sanchez-Gonzalez, Ethel Garc�a Latorre, Olivier Boyer, Remi Varin, Luis Jim�nez-Zamudio, Anne Janin, Jean-Pierre Vannier, Hong Li & He Lu. (2018) Synergistic promoting effects of pentoxifylline and simvastatin on the apoptosis of triple-negative MDA-MB-231 breast cancer cells. International Journal of Oncology.
Crossref
Nancy K. Gillis, Daniel M. Rotroff, Tania E. Mesa, Jiqiang Yao, Zhihua Chen, Michael A. Carulli, Sean J. Yoder, Christine M. Walko, Jamie K. Teer & Howard L. McLeod. (2017) Tumor exome sequencing and copy number alterations reveal potential predictors of intrinsic resistance to multi-targeted tyrosine kinase inhibitors. Oncotarget 8:70, pages 115114-115127.
Crossref
Tetsuya Yumioka, Mitsuhiko Osaki, Ryo Sasaki, Noriya Yamaguchi, Kunishige Onuma, Hideto Iwamoto, Shuichi Morizane, Masashi Honda, Atsushi Takenaka & Futoshi Okada. (2017) Lysosome‑associated membrane protein 2 (LAMP‑2) expression induced by miR‑194‑5p downregulation contributes to sunitinib resistance in human renal cell carcinoma cells. Oncology Letters.
Crossref
Tabea Wiedmer, Annika Blank, Sophia Pantasis, Lea Normand, Ruben Bill, Philippe Krebs, Mario P. Tschan, Ilaria Marinoni & Aurel Perren. (2017) Autophagy Inhibition Improves Sunitinib Efficacy in Pancreatic Neuroendocrine Tumors via a Lysosome-dependent Mechanism. Molecular Cancer Therapeutics 16:11, pages 2502-2515.
Crossref
Amal Kamal Abdel-Aziz, Ashraf B. Abdel-Naim, Samia Shouman, Saverio Minucci & Mohamed Elgendy. (2017) From Resistance to Sensitivity: Insights and Implications of Biphasic Modulation of Autophagy by Sunitinib. Frontiers in Pharmacology 8.
Crossref
Siyuan Yan, Ling Liu, Fengxia Ren, Quan Gao, Shanshan Xu, Bolin Hou, Yange Wang, Xuejun Jiang & Yongsheng Che. (2017) Sunitinib induces genomic instability of renal carcinoma cells through affecting the interaction of LC3-II and PARP-1. Cell Death & Disease 8:8, pages e2988-e2988.
Crossref
Jing Zou, Zhaoyu Chen, Xiaobo Wei, Zhigang Chen, Yongmei Fu, Xiaoyan Yang, Dan Chen, Rui Wang, Peter Jenner, Jia-Hong Lu, Min Li, Zhuohua Zhang, Beisha Tang, Kunlin Jin & Qing Wang. (2017) Cystatin C as a potential therapeutic mediator against Parkinson’s disease via VEGF-induced angiogenesis and enhanced neuronal autophagy in neurovascular units. Cell Death & Disease 8:6, pages e2854-e2854.
Crossref
Jinyang Cai, Ming Sun, Xin Ge & Yue Sun. (2017) EGFR tyrosine kinase inhibitors differentially affect autophagy in head and neck squamous cell carcinoma. Biochemical and Biophysical Research Communications 486:4, pages 1027-1033.
Crossref
Maeva Dufies, Sandy Giuliano, Damien Ambrosetti, Audrey Claren, Papa Diogop Ndiaye, Michalis Mastri, Walid Moghrabi, Lindsay S. Cooley, Marc Ettaiche, Emmanuel Chamorey, Julien Parola, Valerie Vial, Marilena Lupu-Plesu, Jean Christophe Bernhard, Alain Ravaud, Delphine Borchiellini, Jean-Marc Ferrero, Andréas Bikfalvi, John M. Ebos, Khalid Saad Khabar, Renaud Grépin & Gilles Pagès. (2017) Sunitinib Stimulates Expression of VEGFC by Tumor Cells and Promotes Lymphangiogenesis in Clear Cell Renal Cell Carcinomas. Cancer Research 77:5, pages 1212-1226.
Crossref
Thomas Simon, Teresa Gagliano & Georgios Giamas. (2017) Direct Effects of Anti-Angiogenic Therapies on Tumor Cells: VEGF Signaling. Trends in Molecular Medicine 23:3, pages 282-292.
Crossref
Mélanie Guyot, Caroline Hilmi, Damien Ambrosetti, Marco Merlano, Cristiana Lo Nigro, Jérôme Durivault, Renaud Grépin & Gilles Pagès. (2016) Targeting the pro-angiogenic forms of VEGF or inhibiting their expression as anti-cancer strategies. Oncotarget 8:6, pages 9174-9188.
Crossref
Silvia Bono, Matteo Lulli, Vito Giuseppe D'Agostino, Federico Di Gesualdo, Rosa Loffredo, Maria Grazia Cipolleschi, Alessandro Provenzani, Elisabetta Rovida & Persio Dello Sbarba. (2016) Different BCR/Abl protein suppression patterns as a converging trait of chronic myeloid leukemia cell adaptation to energy restriction. Oncotarget 7:51, pages 84810-84825.
Crossref
Xiaoli Ji, Bo Xu, Mengmeng Yao, Zhilei Mao, Yuqing Zhang, Guofeng Xu, Qiusha Tang, Xinru Wang & Yankai Xia. (2016) Graphene oxide quantum dots disrupt autophagic flux by inhibiting lysosome activity in GC-2 and TM4 cell lines. Toxicology 374, pages 10-17.
Crossref
Jian Guan, Zhenchao Yuan, Juliang He, Zhenjie Wu, Bin Liu, Xiang Lin, Ligen Mo & Hao Mo. (2016) Overexpression of caveolin-1 reduces Taxol resistance in human osteosarcoma cells by attenuating PI3K-Akt-JNK dependent autophagy. Experimental and Therapeutic Medicine 12:5, pages 2815-2822.
Crossref
Yuchen Gu, He Lu, Catherine Boisson-Vidal, Hong Li, Guilhem Bousquet, Anne Janin & Mélanie Di Benedetto. (2016) La résistance aux traitements antiangiogéniques. médecine/sciences 32:4, pages 370-377.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.