2,713
Views
72
CrossRef citations to date
0
Altmetric
Basic Research Paper

Autophagy regulates T lymphocyte proliferation through selective degradation of the cell-cycle inhibitor CDKN1B/p27Kip1

, , , , &
Pages 2335-2345 | Received 27 Jun 2013, Accepted 15 Oct 2015, Published online: 06 Jan 2016

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Yiming Lei, Xuan Xu, Huiling Liu, Lingjun Chen, Haoxiong Zhou, Jie Jiang, Yidong Yang & Bin Wu. (2021) HBx induces hepatocellular carcinogenesis through ARRB1-mediated autophagy to drive the G1/S cycle. Autophagy 17:12, pages 4423-4441.
Read now
Gerrit Müller, Charlotte Lübow & Günther Weindl. (2020) Lysosomotropic beta blockers induce oxidative stress and IL23A production in Langerhans cells. Autophagy 16:8, pages 1380-1395.
Read now
Ignacio Guerrero-Ros, Cristina C. Clement, Cara A. Reynolds, Bindi Patel, Laura Santambrogio, Ana M. Cuervo & Fernando Macian. (2020) The negative effect of lipid challenge on autophagy inhibits T cell responses. Autophagy 16:2, pages 223-238.
Read now
Michael J. Kerins, Pengfei Liu, Wang Tian, William Mannheim, Donna D. Zhang & Aikseng Ooi. (2019) Genome-Wide CRISPR Screen Reveals Autophagy Disruption as the Convergence Mechanism That Regulates the NRF2 Transcription Factor. Molecular and Cellular Biology 39:13.
Read now
Anna Onnis, Valentina Cianfanelli, Chiara Cassioli, Dijana Samardzic, Pier Giuseppe Pelicci, Francesco Cecconi & Cosima T Baldari. (2018) The pro-oxidant adaptor p66SHC promotes B cell mitophagy by disrupting mitochondrial integrity and recruiting LC3-II. Autophagy 14:12, pages 2117-2138.
Read now
Siyuan Ma, Xiaohua Chen, Quanhui Tan, Dan Li, Shenglan Dai, Shanshan Wu, Yongsheng Yu, Guoqing Zang & Zhenghao Tang. (2018) An engineered novel lentivector specifically transducing dendritic cells and eliciting robust HBV-specific CTL response by upregulating autophagy in T cells. Cell Cycle 17:10, pages 1220-1234.
Read now
Qiburi He, Yanfeng Wang, Keyu Zhao, Uyanga Binderiya, Lili Bao, Pingping Zhao, Dandan Yan, Huifang Hao, Xudong Guo & Zhigang Wang. (2018) SQSTM1/p62 interacts with FKBP38 and regulates cell cycle in Cashmere goat foetal fibroblasts. Journal of Applied Animal Research 46:1, pages 1247-1252.
Read now

Articles from other publishers (65)

Manuela Giansanti, Tobias Theinert, Sarah Katharina Boeing, Dorothee Haas, Paul-Gerhardt Schlegel, Paola Vacca, Francesca Nazio & Ignazio Caruana. (2023) Exploiting autophagy balance in T and NK cells as a new strategy to implement adoptive cell therapies. Molecular Cancer 22:1.
Crossref
A. Elisabeth Gressler, Houfu Leng, Heidi Zinecker & Anna Katharina Simon. (2023) Proteostasis in T cell aging. Seminars in Immunology 70, pages 101838.
Crossref
Xiangwen Wang, Liwen Zhou, Hongpeng Wang, Wei Chen, Lei Jiang, Guangtao Ming & Jun Wang. (2023) Metabolic reprogramming, autophagy, and ferroptosis: Novel arsenals to overcome immunotherapy resistance in gastrointestinal cancer. Cancer Medicine 12:21, pages 20573-20589.
Crossref
Eleonora A. Starikova, Jennet T. Mammedova, Arina Ozhiganova, Tatiana A. Leveshko, Aleksandra M. Lebedeva, Alexey V. Sokolov, Dmitry V. Isakov, Alena B. Karaseva, Larissa A. Burova & Igor V. Kudryavtsev. (2023) Streptococcal Arginine Deiminase Inhibits T Lymphocyte Differentiation In Vitro. Microorganisms 11:10, pages 2585.
Crossref
Shaodan Chen, Qiulei Wang, Hui Wang & Sheng Xia. (2023) Endoplasmic reticulum stress in T cell‐mediated diseases. Scandinavian Journal of Immunology 98:3.
Crossref
Yuyan Xie, Yang Zhou, Jiale Wang, Lijuan Du, Yuanyuan Ren & Fang Liu. (2023) Ferroptosis, autophagy, tumor and immunity. Heliyon 9:9, pages e19799.
Crossref
Xiao-Li Yang, Yang Wang, Zhi Li, Peng Yu, Meng Lu, Xi-Yin Li, Zhong-Wei Wang, Xiao-Juan Zhang, Jian-Fang Gui & Li Zhou. (2023) Identification of a novel Carassius amphitetraploid clone and its transcriptomic responses to herpesvirus infection. Aquaculture 574, pages 739690.
Crossref
Ahmad Reza Panahi Meymandi, Behnia Akbari, Tahereh Soltantoyeh, Jamshid Hadjati, Daniel J. Klionsky, Behnam Badie & Hamid Reza Mirzaei. (2023) Crosstalk between autophagy and metabolic regulation of (CAR) T cells: therapeutic implications. Frontiers in Immunology 14.
Crossref
Dan Ma, Zewen Wu, Xingxing Zhao, Xueqing Zhu, Qi An, Yajing Wang, Jingwen Zhao, Yazhen Su, Baoqi Yang, Ke Xu & Liyun Zhang. (2023) Immunomodulatory effects of umbilical mesenchymal stem cell-derived exosomes on CD4+ T cells in patients with primary Sjögren's syndrome. Inflammopharmacology 31:4, pages 1823-1838.
Crossref
Nazanin Ghahari, Roman Telittchenko, Hamza Loucif, Stephane Isnard, Jean-Pierre Routy, David Olagnier & Julien van Grevenynghe. (2023) Harnessing Autophagy to Overcome Antigen-Specific T-Cell Dysfunction: Implication for People Living with HIV-1. International Journal of Molecular Sciences 24:13, pages 11018.
Crossref
Mengjiao Lv, Ting Yao, Yi Zhang, Siyuan Ma, Jinmei Chen, Zhenghao Tang, Guoqing Zang & Xiaohua Chen. (2023) Exosomes loading Tapasin enhance T cell immune response by autophagy to inhibit HBV replication. Journal of Medical Virology 95:4.
Crossref
Tiantian Yang, Yang Zhang, Junhang Chen & Longhao Sun. (2023) Crosstalk between autophagy and immune cell infiltration in the tumor microenvironment. Frontiers in Medicine 10.
Crossref
Si-Yuan Lu, Jie Hua, Jiang Liu, Miao-Yan Wei, Chen Liang, Qing-Cai Meng, Bo Zhang, Xian Jun Yu, Wei Wang & Jin Xu. (2022) Turning up the heat on non-immunoreactive tumors: autophagy influences the immune microenvironment in pancreatic cancer. BMC Medical Genomics 15:1.
Crossref
Chaoting Zhang, Yizhe Sun, Shance Li, Luyan Shen, Xia Teng, Yefei Xiao, Nan Wu & Zheming Lu. (2022) Autophagic flux restoration enhances the antitumor efficacy of tumor infiltrating lymphocytes. Journal for ImmunoTherapy of Cancer 10:10, pages e004868.
Crossref
Qihong Yu, Jin-Xin Liu, Xichuan Zheng, Xueke Yan, Peng Zhao, Chuanzheng Yin, Wei Li & Zifang Song. (2022) Sox9 mediates autophagy-dependent vascular smooth muscle cell phenotypic modulation and transplant arteriosclerosis. iScience 25:10, pages 105161.
Crossref
Yuhe Lei, Enxin Zhang, Liangliang Bai & Yingjie Li. (2022) Autophagy in Cancer Immunotherapy. Cells 11:19, pages 2996.
Crossref
Dingxi Zhou, Mariana Borsa, Daniel J. Puleston, Susanne Zellner, Jesusa Capera, Sharon Sanderson, Martina Schifferer, Svenja S. Hester, Xin Ge, Roman Fischer, Luke Jostins, Christian Behrends, Ghada Alsaleh & Anna Katharina Simon. (2022) Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferation. Nature Communications 13:1.
Crossref
Weitong Gao, Xueying Wang, Yang Zhou, Xueqian Wang & Yan Yu. (2022) Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy. Signal Transduction and Targeted Therapy 7:1.
Crossref
Jiung Jeong, Young Joon Choi & Heung Kyu Lee. (2022) The Role of Autophagy in the Function of CD4+ T Cells and the Development of Chronic Inflammatory Diseases. Frontiers in Pharmacology 13.
Crossref
Dorian V. Ziegler, Katharina Huber & Lluis Fajas. (2021) The Intricate Interplay between Cell Cycle Regulators and Autophagy in Cancer. Cancers 14:1, pages 153.
Crossref
Man Lyang Kim, Melinda Y. Hardy, Laura E. Edgington-Mitchell, Sri H. Ramarathinam, Shan Zou Chung, Amy K. Russell, Iain Currie, Brad E. Sleebs, Anthony W. Purcell, Jason A. Tye-Din & Ian P. Wicks. (2021) Hydroxychloroquine inhibits the mitochondrial antioxidant system in activated T cells. iScience 24:12, pages 103509.
Crossref
Bhupinder Singh, Guru P. Maiti, Xujie Zhou, Mehdi Fazel‐Najafabadi, Sang‐Cheol Bae, Celi Sun, Chikashi Terao, Yukinori Okada, Kek Heng Chua, Yuta Kochi, Joel M. Guthridge, Hong Zhang, Matthew Weirauch, Judith A. James, John B. Harley, Gaurav K. Varshney, Loren L. Looger & Swapan K. Nath. (2021) Lupus Susceptibility Region Containing CDKN1B rs34330 Mechanistically Influences Expression and Function of Multiple Target Genes, Also Linked to Proliferation and Apoptosis . Arthritis & Rheumatology 73:12, pages 2303-2313.
Crossref
Chien-An Chu, Yi-Wen Wang, Yi-Lin Chen, Hui-Wen Chen, Jing-Jing Chuang, Hong-Yi Chang, Chung-Liang Ho, Chen Chang, Nan-Haw Chow & Chung-Ta Lee. (2021) The Role of Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3 in the Pathogenesis of Human Cancer. International Journal of Molecular Sciences 22:20, pages 10964.
Crossref
Yuxiang Fan, Yubo Wang, Jian Zhang, Xuechao Dong, Pu Gao, Kai Liu, Chengyuan Ma & Gang Zhao. (2021) Breaking Bad: Autophagy Tweaks the Interplay Between Glioma and the Tumor Immune Microenvironment. Frontiers in Immunology 12.
Crossref
Nina Germic, Aref Hosseini, Shida Yousefi, Alexander Karaulov & Hans-Uwe Simon. (2021) Regulation of eosinophil functions by autophagy. Seminars in Immunopathology 43:3, pages 347-362.
Crossref
Ting Jiang, Xisha Chen, Xingcong Ren, Jin-Ming Yang & Yan Cheng. (2021) Emerging role of autophagy in anti-tumor immunity: Implications for the modulation of immunotherapy resistance. Drug Resistance Updates 56, pages 100752.
Crossref
Francesca Finetti, Chiara Cassioli, Valentina Cianfanelli, Fabrizia Zevolini, Anna Onnis, Monica Gesualdo, Jlenia Brunetti, Francesco Cecconi & Cosima T. Baldari. (2021) The Intraflagellar Transport Protein IFT20 Recruits ATG16L1 to Early Endosomes to Promote Autophagosome Formation in T Cells. Frontiers in Cell and Developmental Biology 9.
Crossref
Kaori Masuhara, Hisako Akatsuka, Mizuki Tokusanai, Chenyang Li, Yumi Iida, Yoshinori Okada, Takahiro Suzuki, Masato Ohtsuka, Ituro Inoue, Minoru Kimura, Hiroyuki Hosokawa, Katsuto Hozumi & Takehito Sato. (2021) AMBRA1 controls antigen-driven activation and proliferation of naive T cells. International Immunology 33:2, pages 107-118.
Crossref
Hai-Peng Li, Ji-Ting Liu, Yuan-Xiu Chen, Wen-Bin Wang, Yue Han, Qing-Ping Yao & Ying-Xin Qi. (2021) Suppressed nuclear envelope proteins activate autophagy of vascular smooth muscle cells during cyclic stretch application. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1868:1, pages 118855.
Crossref
Ghada Alsaleh, Isabel Panse, Leo Swadling, Hanlin Zhang, Felix Clemens Richter, Alain Meyer, Janet Lord, Eleanor Barnes, Paul Klenerman, Christopher Green & Anna Katharina Simon. (2020) Autophagy in T cells from aged donors is maintained by spermidine and correlates with function and vaccine responses. eLife 9.
Crossref
Shahram Golbabapour, Kamran Bagheri-Lankarani, Saeid Ghavami & Bita Geramizadeh. (2020) Autoimmune Hepatitis and Stellate Cells: An Insight into the Role of Autophagy. Current Medicinal Chemistry 27:35, pages 6073-6095.
Crossref
Marina Andrade-Tomaz, Izadora de Souza, Clarissa Ribeiro Reily Rocha & Luciana Rodrigues Gomes. (2020) The Role of Chaperone-Mediated Autophagy in Cell Cycle Control and Its Implications in Cancer. Cells 9:9, pages 2140.
Crossref
Ada Nowosad, Pauline Jeannot, Caroline Callot, Justine Creff, Renaud Thierry Perchey, Carine Joffre, Patrice Codogno, Stephane Manenti & Arnaud Besson. (2020) p27 controls Ragulator and mTOR activity in amino acid-deprived cells to regulate the autophagy–lysosomal pathway and coordinate cell cycle and cell growth. Nature Cell Biology 22:9, pages 1076-1090.
Crossref
Ruixue Huang, Shanshan Gao, Yanqin Han, Huacheng Ning, Yao Zhou, Hua Guan, Xiaodan Liu, Shuang Yan & Ping-Kun Zhou. (2020) BECN1 promotes radiation-induced G2/M arrest through regulation CDK1 activity: a potential role for autophagy in G2/M checkpoint. Cell Death Discovery 6:1.
Crossref
Jacob D. Painter, Lauriane Galle-Treger & Omid Akbari. (2020) Role of Autophagy in Lung Inflammation. Frontiers in Immunology 11.
Crossref
Vibhuti Joshi, Arun Upadhyay, Vijay K. Prajapati & Amit Mishra. (2020) How autophagy can restore proteostasis defects in multiple diseases?. Medicinal Research Reviews 40:4, pages 1385-1439.
Crossref
Jingting Zhu, Lingyan Yang, Qibo Zhang, Jia Meng, Zhi-Liang Lu & Rong Rong. (2020) Autophagy Induced by Simian Retrovirus Infection Controls Viral Replication and Apoptosis of Jurkat T Lymphocytes. Viruses 12:4, pages 381.
Crossref
Yue Fu, Na Yao, Dong Ding, Xudong Zhang, Hanyang Liu, Le Ma, Weihai Shi, Chunfu Zhu & Liming Tang. (2019) TMEM158 promotes pancreatic cancer aggressiveness by activation of TGFβ1 and PI3K/AKT signaling pathway. Journal of Cellular Physiology 235:3, pages 2761-2775.
Crossref
Hang Yu Wang, Can Li, Wei Hua Liu, Feng Mei Deng, Yan Ma, Li Na Guo, De Hua Kong, Kang An Hu, Qin Liu, Jiang Wu, Jing Sun & Yi Lun Liu. (2019) Autophagy inhibition via Becn1 downregulation improves the mesenchymal stem cells antifibrotic potential in experimental liver fibrosis . Journal of Cellular Physiology 235:3, pages 2722-2737.
Crossref
Shengjun Fan, Trevor Price, Wei Huang, Michelle Plue, Jonathan Warren, Pasupathi Sundaramoorthy, Barry Paul, Daniel Feinberg, Nancie MacIver, Nelson Chao, Dorothy Sipkins & Yubin Kang. (2020) PINK1‐Dependent Mitophagy Regulates the Migration and Homing of Multiple Myeloma Cells via the MOB1B‐Mediated Hippo‐YAP/TAZ Pathway. Advanced Science 7:5.
Crossref
Guan-Min Jiang, Yuan Tan, Hao Wang, Liang Peng, Hong-Tao Chen, Xiao-Jun Meng, Ling-Ling Li, Yan Liu, Wen-Fang Li & Hong Shan. (2019) The relationship between autophagy and the immune system and its applications for tumor immunotherapy. Molecular Cancer 18:1.
Crossref
Fernando Macian. (2019) Autophagy in T Cell Function and Aging. Frontiers in Cell and Developmental Biology 7.
Crossref
Yahong You, Jiali Huo, Jinbo Huang, Min Wang, Yingqi Shao, Meili Ge, Xingxin Li, Zhendong Huang, Jing Zhang, Neng Nie & Yizhou Zheng. (2019) Contribution of autophagy‐related gene 5 variants to acquired aplastic anemia in Han‐Chinese population. Journal of Cellular Biochemistry 120:7, pages 11409-11417.
Crossref
Alexander J. Clarke & Anna Katharina Simon. (2018) Autophagy in the renewal, differentiation and homeostasis of immune cells. Nature Reviews Immunology 19:3, pages 170-183.
Crossref
Hendrik Folkerts, Susan Hilgendorf, Edo Vellenga, Edwin Bremer & Valerie R. Wiersma. (2018) The multifaceted role of autophagy in cancer and the microenvironment. Medicinal Research Reviews 39:2, pages 517-560.
Crossref
Wenzhuo He, Wenjing Xiong & Xiaojun Xia. 2019. Autophagy Regulation of Innate Immunity. Autophagy Regulation of Innate Immunity 7 22 .
Fernando Macian. 2019. Handbook of Immunosenescence. Handbook of Immunosenescence 1359 1378 .
Fernando Macian. 2018. Handbook of Immunosenescence. Handbook of Immunosenescence 1 20 .
Seth D. Merkley, Cameron J. Chock, Xuexian O. Yang, James Harris & Eliseo F. Castillo. (2018) Modulating T Cell Responses via Autophagy: The Intrinsic Influence Controlling the Function of Both Antigen-Presenting Cells and T Cells. Frontiers in Immunology 9.
Crossref
Florent Arbogast & Frédéric Gros. (2018) Lymphocyte Autophagy in Homeostasis, Activation, and Inflammatory Diseases. Frontiers in Immunology 9.
Crossref
Enric Mocholi, Samuel D. Dowling, Yair Botbol, Ross C. Gruber, Alex K. Ray, Sebastiaan Vastert, Bridget Shafit-Zagardo, Paul J. Coffer & Fernando Macian. (2018) Autophagy Is a Tolerance-Avoidance Mechanism that Modulates TCR-Mediated Signaling and Cell Metabolism to Prevent Induction of T Cell Anergy. Cell Reports 24:5, pages 1136-1150.
Crossref
Elise Jacquin & Lionel Apetoh. (2018) Cell-Intrinsic Roles for Autophagy in Modulating CD4 T Cell Functions. Frontiers in Immunology 9.
Crossref
Yu Matsuzawa-IshimotoSeungmin HwangKen Cadwell. (2018) Autophagy and Inflammation. Annual Review of Immunology 36:1, pages 73-101.
Crossref
Diane Murera, Florent Arbogast, Johan Arnold, Delphine Bouis, Sylviane Muller & Frédéric Gros. (2018) CD4 T cell autophagy is integral to memory maintenance. Scientific Reports 8:1.
Crossref
Samuel D. Dowling & Fernando Macian. (2018) Autophagy and T cell metabolism. Cancer Letters 419, pages 20-26.
Crossref
Q Heydt, C Larrue, E Saland, S Bertoli, J-E Sarry, A Besson, S Manenti, C Joffre & V Mansat-De Mas. (2017) Oncogenic FLT3-ITD supports autophagy via ATF4 in acute myeloid leukemia. Oncogene 37:6, pages 787-797.
Crossref
Wei Jia, Ian McLeod, Ming-Xiao He & You-Wen He. 2018. Immunology. Immunology 23 33 .
Yun-Peng Peng, Yi Zhu, Ling-Di Yin, Jing-Jing Zhang, Ji-Shu Wei, Xian Liu, Xin-Chun Liu, Wen-Tao Gao, Kui-Rong Jiang & Yi Miao. (2017) PEG10 overexpression induced by E2F-1 promotes cell proliferation, migration, and invasion in pancreatic cancer. Journal of Experimental & Clinical Cancer Research 36:1.
Crossref
Debora Bencivenga, Ilaria Caldarelli, Emanuela Stampone, Francesco Paolo Mancini, Maria Luisa Balestrieri, Fulvio Della Ragione & Adriana Borriello. (2017) p27 Kip1 and human cancers: A reappraisal of a still enigmatic protein. Cancer Letters 403, pages 354-365.
Crossref
Jilong Zhou, Wang Yao, Chengyu Li, Wangjun Wu, Qifa Li & Honglin Liu. (2017) Administration of follicle-stimulating hormone induces autophagy via upregulation of HIF-1α in mouse granulosa cells. Cell Death & Disease 8:8, pages e3001-e3001.
Crossref
Guihua Qiu, Jian Liu, Qianqian Cheng, Qingyang Wang, Zhaofei Jing, Yujun Pei, Min Zhao, Jing Wang, Jessie Yanxiang Guo & Jiyan Zhang. (2017) Impaired Autophagy and Defective T Cell Homeostasis in Mice with T Cell-Specific Deletion of Receptor for Activated C Kinase 1. Frontiers in Immunology 8.
Crossref
Xiao Liu, Haihong Qin & Jinhua Xu. (2016) The role of autophagy in the pathogenesis of systemic lupus erythematosus. International Immunopharmacology 40, pages 351-361.
Crossref
Hanlin Zhang, Daniel J. Puleston & Anna Katharina Simon. (2016) Autophagy and Immune Senescence. Trends in Molecular Medicine 22:8, pages 671-686.
Crossref
Tao Liu, Qin Tang, Kunpeng Liu, Weihong Xie, Xin Liu, Huishan Wang, Rong-Fu Wang & Jun Cui. (2016) TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p62-Dependent Selective Autophagy. Cell Reports 16:7, pages 1988-2002.
Crossref
Yair Botbol, Ignacio Guerrero-Ros & Fernando Macian. (2016) Key roles of autophagy in regulating T-cell function. European Journal of Immunology 46:6, pages 1326-1334.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.