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Autophagy Volume 12, 2016 - Issue 10
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Basic Research Papers

Anti-aging treatments slow propagation of synucleinopathy by restoring lysosomal function

Dong-Kyu KimDepartment of Biomedical Sciences and Neuroscience Research Institute, Seoul National University College of Medicine, Seoul, Korea;Department of Biomedical Science and Technology, Konkuk University, Seoul, Korea
,
Hee-Sun LimDepartment of Biomedical Science and Technology, Konkuk University, Seoul, Korea
,
Ichiro KawasakiDepartment of Bioscience and Biotechnoloy and Institute of KU Biotechnology, Konkuk University, Seoul, Korea
,
Yhong-Hee ShimDepartment of Bioscience and Biotechnoloy and Institute of KU Biotechnology, Konkuk University, Seoul, Korea
,
Nishant N. VaikathDepartment of Biochemistry, College of Medicine and Health Science, United Arab University, Al Ain, United Arab Emirates
,
Omar M. A. El-AgnafNeurological Disorders Center, Qatar Biomedical Research Institute (QBRI), and College of Science and Engineering, Hamad Bin Khalifa University (HBKU), Education City, Qatar Foundation, Doha, Qatar
,
He-Jin LeeDepartment of Anatomy, School of Medicine, Konkuk University, Seoul, Korea
&
Seung-Jae LeeDepartment of Biomedical Sciences and Neuroscience Research Institute, Seoul National University College of Medicine, Seoul, KoreaCorrespondence[email protected]
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Pages 1849-1863 | Received 04 Jan 2016, Accepted 22 Jun 2016, Published online: 19 Aug 2016

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Margaret MP Pearce. (2017) Prion-like transmission of pathogenic protein aggregates in genetic models of neurodegenerative disease. Current Opinion in Genetics & Development 44, pages 149-155.
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Bryan A Martinez, Kim A Caldwell & Guy A Caldwell. (2017) C . elegans as a model system to accelerate discovery for Parkinson disease. Current Opinion in Genetics & Development 44, pages 102-109.
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