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Research Papers - Basic Science

HSPA5 negatively regulates lysosomal activity through ubiquitination of MUL1 in head and neck cancer

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Pages 385-403 | Received 29 Mar 2017, Accepted 01 Dec 2017, Published online: 21 Feb 2018

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N. Yu, J. Yang, Y. Mishina & W.V. Giannobile. (2018) Genome Editing: A New Horizon for Oral and Craniofacial Research. Journal of Dental Research 98:1, pages 36-45.
Crossref
Sheng Chen, Jian Wu, Kai Jiao, Qiong Wu, Jiaojiao Ma, Di Chen, Jianqin Kang, Guodong Zhao, Yongquan Shi, Daiming Fan & Guohong Zhao. (2018) MicroRNA-495-3p inhibits multidrug resistance by modulating autophagy through GRP78/mTOR axis in gastric cancer. Cell Death & Disease 9:11.
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