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Autophagy Volume 16, 2020 - Issue 4
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Translational Research Paper

SNX10 (sorting nexin 10) inhibits colorectal cancer initiation and progression by controlling autophagic degradation of SRC

Sulin ZhangDepartment of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China;Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, ChinaView further author information
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Zhiwen YangDepartment of Pharmacy, Songjiang Hospital Affiliated Shanghai First People’s Hospital, Shanghai Jiao Tong University, Shanghai, ChinaView further author information
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Weilian BaoDepartment of Pharmacology, School of Pharmacy, Fudan University, Shanghai, ChinaView further author information
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Lixin LiuDepartment of Pharmacology, School of Pharmacy, Fudan University, Shanghai, ChinaView further author information
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Yan YouDepartment of Pharmacology, School of Pharmacy, Fudan University, Shanghai, ChinaView further author information
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Xu WangDepartment of Pharmacology, School of Pharmacy, Fudan University, Shanghai, ChinaView further author information
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Liming ShaoDepartment of Pharmacology, School of Pharmacy, Fudan University, Shanghai, ChinaView further author information
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Wei FuDepartment of Pharmacology, School of Pharmacy, Fudan University, Shanghai, ChinaView further author information
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Xinhui KouDepartment of Pharmacology, School of Pharmacy, Fudan University, Shanghai, ChinaView further author information
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Weixing ShenThe Translational Medicine Research Center, Nanjing University of Traditional Chinese Medicine, Nanjing, ChinaView further author information
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Congmin YuanDepartment of Pharmacology, School of Pharmacy, Fudan University, Shanghai, ChinaView further author information
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Bin HuDepartment of Pharmacology, School of Pharmacy, Fudan University, Shanghai, ChinaView further author information
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Wenzhen DangDepartment of Pharmacology, School of Pharmacy, Fudan University, Shanghai, ChinaView further author information
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Kutty Selva NandakumarSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou, ChinaORCID Iconhttps://orcid.org/0000-0001-7790-8197View further author information
ORCID Icon,
Hualiang JiangDrug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, ChinaView further author information
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Mingyue ZhengDrug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, ChinaCorrespondence[email protected]
View further author information
&
Xiaoyan ShenDepartment of Pharmacology, School of Pharmacy, Fudan University, Shanghai, ChinaCorrespondence[email protected]
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Pages 735-749 | Received 25 Jan 2019, Accepted 10 Jun 2019, Published online: 04 Jul 2019

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Yongqiang Chen, Zhaoying Zhang, Elizabeth S. Henson, Andrew Cuddihy, Katharina Haigh, Ruobing Wang, Jody J. Haigh & Spencer B. Gibson. (2022) Autophagy inhibition by TSSC4 (tumor suppressing subtransferable candidate 4) contributes to sustainable cancer cell growth. Autophagy 18:6, pages 1274-1296.
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Wei-Lian Bao, Qibiao Wu, Bin Hu, Dongdong Sun, Shengnan Zhao, Xiaoyan Shen, Haibo Cheng & Weixing Shen. (2021) Oral Nanoparticles of SNX10-shRNA Plasmids Ameliorate Mouse Colitis. International Journal of Nanomedicine 16, pages 345-357.
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Gu Jie Wu, Kuan Ren, Min He, Jian Xun Xu, Zhen Qing Li, Ding Bo & Qun Xue. (2021) SNX20 Expression Correlates with Immune Cell Infiltration and Can Predict Prognosis in Lung Adenocarcinoma. International Journal of General Medicine 14, pages 7599-7611.
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Rong‐rong Deng & You‐ping Yuan. (2023) Ropivacaine inhibits the proliferation and metastasis of gastric cancer cells via the SNX10/SRC/STAT3 pathway. Chemical Biology & Drug Design.
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Tian-Fei Ma, Yue-Ren Fan, Yi-Hang Zhao & Bin Liu. (2023) Emerging role of autophagy in colorectal cancer: Progress and prospects for clinical intervention. World Journal of Gastrointestinal Oncology 15:6, pages 979-987.
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Xingrui Cai, Hui Yang, Yinglian Pan, Yang Wen, Chengmou Huang & Rucai Li. (2023) Circ_0060967 contributes to colorectal cancer progression by sponging miR-1184 to up-regulate SRC proto-oncogene. Arab Journal of Gastroenterology 24:2, pages 117-128.
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Ryan C. Gimple, Guoxin Zhang, Shuai Wang, Tengfei Huang, Jina Lee, Suchet Taori, Deguan Lv, Deobrat Dixit, Matthew E. Halbert, Andrew R. Morton, Reilly L. Kidwell, Zhen Dong, Briana C. Prager, Leo J.Y. Kim, Zhixin Qiu, Linjie Zhao, Qi Xie, Qiulian Wu, Sameer Agnihotri & Jeremy N. Rich. (2023) Sorting nexin 10 sustains PDGF receptor signaling in glioblastoma stem cells via endosomal protein sorting. JCI Insight 8:6.
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Hui Feng, Jiani Tan, Qijuan Wang, Tingting Zhou, Liu Li, Dongdong Sun, Minmin Fan, Haibo Cheng & Weixing Shen. (2023) α-hederin regulates glucose metabolism in intestinal epithelial cells by increasing SNX10 expression. Phytomedicine 111, pages 154677.
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Chengfei Xu, Fanghan Li, Zilin Liu, Chuanjing Yan & Jiangwei Xiao. (2023) Pan-cancer analysis of the prognostic and immunological role of SNX29: a potential target for survival and immunotherapy. BMC Medical Genomics 16:1.
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Juan Huang, Andrew C. Tiu, Pedro A. Jose & Jian Yang. (2021) Sorting nexins: role in the regulation of blood pressure. The FEBS Journal 290:3, pages 600-619.
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Yatian Yang, Chengcheng Qian, Rui Wu, Rui Wang, Jinmei Ou & Shoujin Liu. (2023) Exploring the mechanism of the Fructus Mume and Rhizoma Coptidis herb pair intervention in Ulcerative Colitis from the perspective of inflammation and immunity based on systemic pharmacology. BMC Complementary Medicine and Therapies 23:1.
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Zhiying Tian, Asif Iqbal Khan, Ata Ur Rehman, Ting Deng, Chao Ma & Liang Wang. (2023) Virulence factors and mechanisms of paediatric pneumonia caused by Enterococcus faecalis. Gut Pathogens 15:1.
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Weibo Dai, Jing Yang, Xin Liu, Quanxi Mei, Weijie Peng & Xianjing Hu. (2023) Anti-colorectal cancer of Ardisia gigantifolia Stapf. and targets prediction via network pharmacology and molecular docking study. BMC Complementary Medicine and Therapies 23:1.
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Shreya Deb & Jun Sun. (2022) Endosomal Sorting Protein SNX27 and Its Emerging Roles in Human Cancers. Cancers 15:1, pages 70.
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Beibei Hu, Guohui Yin & Xuren Sun. (2022) Identification of specific role of SNX family in gastric cancer prognosis evaluation. Scientific Reports 12:1.
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Liming Qiang, Hongpeng Li, Zhaohui Wang, Lin Wan & Guangfu Jiang. (2022) Deconvoluting the complexity of autophagy in colorectal cancer: From crucial pathways to targeted therapies. Frontiers in Oncology 12.
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Zonglang Lai, Huaibi Wang, Xiaohui Tang, Liufan Zhang, Tiantian Wang & Jun Cheng. (2022) Study on the Mechanism of Diosgenin Targeting STAT3 to Inhibit Colon Cancer Proliferation and Migration. Disease Markers 2022, pages 1-14.
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Fengsong Liu, Xiaojian Pang, Ziqi Yu & Kai Wang. (2022) Differential gene expression analysis for osteosarcoma lung metastases. Cancer Biomarkers 33:3, pages 379-387.
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Qingqing Zhou, Jiajun Li, Chao Ge, Jinsi Chen, Wei Tian & Hua Tian. (2022) SNX5 suppresses clear cell renal cell carcinoma progression by inducing CD44 internalization and epithelial-to-mesenchymal transition. Molecular Therapy - Oncolytics 24, pages 87-100.
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Xu Wang, Jiahui Ni, Yan You, Guize Feng, Sulin Zhang, Weilian Bao, Hui Hou, Haidong Li, Lixin Liu, Mingyue Zheng, Yirui Wang, Hua Zhou, Weixing Shen & Xiaoyan Shen. (2021) SNX10‐mediated LPS sensing causes intestinal barrier dysfunction via a caspase‐5‐dependent signaling cascade. The EMBO Journal 40:24.
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Weilian Bao, Xiaohong Liu, Yan You, Hui Hou, Xu Wang, Sulin Zhang, Haidong Li, Guize Feng, Xinyu Cao, Hualiang Jiang, Mingyue Zheng & Xiaoyan Shen. (2021) Targeting sorting nexin 10 improves mouse colitis via inhibiting PIKfyve-mediated TBK1/c-Rel signaling activation. Pharmacological Research 169, pages 105679.
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Jiake Xu, Heng Qiu, Jinmin Zhao & Nathan J. Pavlos. (2020) The molecular structure and function of sorting nexin 10 in skeletal disorders, cancers, and other pathological conditions. Journal of Cellular Physiology 236:6, pages 4207-4215.
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Ari Elson, Merle Stein, Grace Rabie, Maayan Barnea-Zohar, Sabina Winograd-Katz, Nina Reuven, Moran Shalev, Juraj Sekeres, Moien Kanaan, Jan Tuckermann & Benjamin Geiger. (2021) Sorting Nexin 10 as a Key Regulator of Membrane Trafficking in Bone-Resorbing Osteoclasts: Lessons Learned From Osteopetrosis. Frontiers in Cell and Developmental Biology 9.
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Lu Yang, Weihua Tan, Xinzhi Yang, Yong You, Jing Wang, Gebo Wen & Jing Zhong. (2020) Sorting nexins: A novel promising therapy target for cancerous/neoplastic diseases. Journal of Cellular Physiology 236:5, pages 3317-3335.
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Weilei Hu, Guosheng Wang, Lonny B. Yarmus & Yuan Wan. (2020) Combined Methylome and Transcriptome Analyses Reveals Potential Therapeutic Targets for EGFR Wild Type Lung Cancers with Low PD-L1 Expression. Cancers 12:9, pages 2496.
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Audrey Sirvent, Rudy Mevizou, Dana Naim, Marie Lafitte & Serge Roche. (2020) Src Family Tyrosine Kinases in Intestinal Homeostasis, Regeneration and Tumorigenesis. Cancers 12:8, pages 2014.
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Yihang Yuan, Ji Chen, Jue Wang, Ming Xu, Yunpeng Zhang, Peng Sun & Leilei Liang. (2020) Identification Hub Genes in Colorectal Cancer by Integrating Weighted Gene Co-Expression Network Analysis and Clinical Validation in vivo and vitro. Frontiers in Oncology 10.
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