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Autophagy Volume 16, 2020 - Issue 7
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Research Paper

Tanycytic TSPO inhibition induces lipophagy to regulate lipid metabolism and improve energy balance

Seolsong Kima Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of KoreaView further author information
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Nayoun Kima Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of KoreaView further author information
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Seokjae Parka Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of Korea;b Neurometabolomics Research Center, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of KoreaView further author information
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Yoonjeong Jeona Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of Korea;b Neurometabolomics Research Center, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of KoreaView further author information
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Jaemeun Leea Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of KoreaView further author information
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Seung-Jun Yooa Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of Korea;c Convergence Research Advanced Centre for Olfaction, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of KoreaView further author information
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Ji-Won Leea Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of KoreaView further author information
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Cheil Moona Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of Korea;c Convergence Research Advanced Centre for Olfaction, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of KoreaORCID Iconhttps://orcid.org/0000-0002-9741-7229View further author information
ORCID Icon,
Seong-Woon Yua Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of Korea;b Neurometabolomics Research Center, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of KoreaView further author information
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Eun-Kyoung Kima Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of Korea;b Neurometabolomics Research Center, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of KoreaCorrespondence[email protected]
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Pages 1200-1220 | Received 19 Dec 2018, Accepted 09 Aug 2019, Published online: 30 Aug 2019

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Seokjae Park, Tae Seok Oh, Seolsong Kim & Eun-Kyoung Kim. (2019) Palmitate-induced autophagy liberates monounsaturated fatty acids and increases Agrp expression in hypothalamic cells. Animal Cells and Systems 23:6, pages 384-391.
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Sreekala Nampoothiri, Ruben Nogueiras, Markus Schwaninger & Vincent Prevot. (2022) Glial cells as integrators of peripheral and central signals in the regulation of energy homeostasis. Nature Metabolism 4:7, pages 813-825.
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Yanan Wang, Jiachen Shi, Fan Jiang, Yong-Jiang Xu & Yuanfa Liu. (2022) Metabolomics reveals the impact of the saturation of dietary lipids on the aging and longevity of C. elegans . Molecular Omics 18:5, pages 430-438.
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Yun Lim, Seolsong Kim & Eun-Kyoung Kim. (2021) Palmitate reduces starvation-induced ER stress by inhibiting ER-phagy in hypothalamic cells. Molecular Brain 14:1.
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Magdiel Salgado, María Á. García-Robles & Juan C. Sáez. (2021) Purinergic signaling in tanycytes and its contribution to nutritional sensing. Purinergic Signalling 17:4, pages 607-618.
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Nicole A. Morrissey, Craig Beall & Kate L. J. Ellacott. (2021) Absence of the mitochondrial translocator protein 18 kDa in mice does not affect body weight or food intake responses to altered energy availability. Journal of Neuroendocrinology 33:9.
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Joshua Wang & Kate Beecher. (2021) TSPO: an emerging role in appetite for a therapeutically promising biomarker. Open Biology 11:8.
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Serena Mirra, Rocío García-Arroyo, Elena B. Domènech, Aleix Gavaldà-Navarro, Carlos Herrera-Úbeda, Clara Oliva, Jordi Garcia-Fernàndez, Rafael Artuch, Francesc Villarroya & Gemma Marfany. (2021) CERKL, a retinal dystrophy gene, regulates mitochondrial function and dynamics in the mammalian retina. Neurobiology of Disease 156, pages 105405.
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Carrie Hiser, Beronda L. Montgomery & Shelagh Ferguson-Miller. (2021) TSPO protein binding partners in bacteria, animals, and plants. Journal of Bioenergetics and Biomembranes 53:4, pages 463-487.
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Matei Bolborea & Fanny Langlet. (2021) What is the physiological role of hypothalamic tanycytes in metabolism?. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 320:6, pages R994-R1003.
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Yuchang Li, Liting Chen, Lu Li, Chantal Sottas, Stephanie K. Petrillo, Anthoula Lazaris, Peter Metrakos, Hangyu Wu, Yuji Ishida, Takeshi Saito, Lucy Golden-Mason, Hugo R. Rosen, Jeremy J. Wolff, Cristina I. Silvescu, Samuel Garza, Garett Cheung, Tiffany Huang, Jinjiang Fan, Martine Culty, Bangyan Stiles, Kinji Asahina & Vassilios Papadopoulos. (2021) Cholesterol-binding translocator protein TSPO regulates steatosis and bile acid synthesis in nonalcoholic fatty liver disease. iScience 24:5, pages 102457.
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Vincent Prevot, Ruben Nogueiras & Markus Schwaninger. 2021. The Human Hypothalamus - Middle and Posterior Region. The Human Hypothalamus - Middle and Posterior Region 253 273 .
Brandon C. Farmer, Adeline E. Walsh, Jude C. Kluemper & Lance A. Johnson. (2020) Lipid Droplets in Neurodegenerative Disorders. Frontiers in Neuroscience 14.
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Helge Müller-Fielitz & Markus Schwaninger. (2019) The Role of Tanycytes in the Hypothalamus-Pituitary-Thyroid Axis and the Possibilities for Their Genetic Manipulation. Experimental and Clinical Endocrinology & Diabetes 128:06/07, pages 388-394.
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Calina Betlazar, Ryan J. Middleton, Richard Banati & Guo-Jun Liu. (2020) The Translocator Protein (TSPO) in Mitochondrial Bioenergetics and Immune Processes. Cells 9:2, pages 512.
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Younghwan Lee, Youngjin Park, Hyeri Nam, Ji-Won Lee & Seong-Woon Yu. (2020) Translocator protein (TSPO): the new story of the old protein in neuroinflammation. BMB Reports 53:1, pages 20-27.
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Fanny Langlet. (2020) Targeting Tanycytes: Balance between Efficiency and Specificity. Neuroendocrinology 110:7-8, pages 574-581.
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