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Autophagy Volume 17, 2021 - Issue 7
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Research Paper

PKD2/polycystin-2 induces autophagy by forming a complex with BECN1

Daniel Peña-Oyarzuna Instituto de Investigación en Ciencias Odontológicas (ICOD), Facultad de Odontología, Universidad de Chile, Santiago, Chile;b Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas & Facultad de Medicina, Universidad de Chile, Santiago, ChileORCID Iconhttps://orcid.org/0000-0001-8881-8074View further author information
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Marcelo Rodriguez-Peñaa Instituto de Investigación en Ciencias Odontológicas (ICOD), Facultad de Odontología, Universidad de Chile, Santiago, Chile;b Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas & Facultad de Medicina, Universidad de Chile, Santiago, ChileORCID Iconhttps://orcid.org/0000-0002-7948-468XView further author information
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Francesca Burgos-Bravoc Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, ChileORCID Iconhttps://orcid.org/0000-0002-2306-1266View further author information
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Angelo Vergaraa Instituto de Investigación en Ciencias Odontológicas (ICOD), Facultad de Odontología, Universidad de Chile, Santiago, Chile;b Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas & Facultad de Medicina, Universidad de Chile, Santiago, ChileORCID Iconhttps://orcid.org/0000-0001-7898-0297View further author information
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Catalina Kretschmara Instituto de Investigación en Ciencias Odontológicas (ICOD), Facultad de Odontología, Universidad de Chile, Santiago, Chile;b Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas & Facultad de Medicina, Universidad de Chile, Santiago, ChileORCID Iconhttps://orcid.org/0000-0002-2365-6251View further author information
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Cristian Sotomayor-Floresb Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas & Facultad de Medicina, Universidad de Chile, Santiago, ChileORCID Iconhttps://orcid.org/0000-0001-8988-6167View further author information
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Cesar A. Ramirez-Sarmientod Institute for Biological and Medical Engineering, Facultades de Ingenieria, Medicina y Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, ChileORCID Iconhttps://orcid.org/0000-0003-4647-903XView further author information
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Humbert De Smedte Department of Cellular and Molecular Medicine, Katholieke Universiteit Leuven, BelgiumORCID Iconhttps://orcid.org/0000-0002-6459-603XView further author information
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Montserrat Reyesa Instituto de Investigación en Ciencias Odontológicas (ICOD), Facultad de Odontología, Universidad de Chile, Santiago, Chile;f Department of Pathology and Oral Medicine, Faculty of Dentistry, Universidad de Chile, Santiago, ChileORCID Iconhttps://orcid.org/0000-0002-4116-4074View further author information
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William Perezg Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX, USAORCID Iconhttps://orcid.org/0000-0003-0344-4160View further author information
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Vicente A. Torresa Instituto de Investigación en Ciencias Odontológicas (ICOD), Facultad de Odontología, Universidad de Chile, Santiago, Chile;b Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas & Facultad de Medicina, Universidad de Chile, Santiago, ChileORCID Iconhttps://orcid.org/0000-0002-5973-7248View further author information
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Eugenia Morsellih Departamento de Fisiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, ChileORCID Iconhttps://orcid.org/0000-0002-7840-8351View further author information
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Francisco Altamiranog Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX, USAORCID Iconhttps://orcid.org/0000-0002-1612-2729View further author information
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Christian A. M. Wilsonc Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, ChileORCID Iconhttps://orcid.org/0000-0002-6499-6957View further author information
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Joseph A. Hilli Cardiology Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA;j Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USAORCID Iconhttps://orcid.org/0000-0002-5379-1614View further author information
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Sergio Lavanderob Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas & Facultad de Medicina, Universidad de Chile, Santiago, Chile;c Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, Chile;i Cardiology Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-4258-1483View further author information
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Alfredo Criolloa Instituto de Investigación en Ciencias Odontológicas (ICOD), Facultad de Odontología, Universidad de Chile, Santiago, Chile;b Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas & Facultad de Medicina, Universidad de Chile, Santiago, Chile;k Autophagy Research Center, Universidad de Chile, Santiago, ChileCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-2737-7751View further author information
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Pages 1714-1728 | Received 01 Dec 2019, Accepted 03 Jun 2020, Published online: 30 Jun 2020

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Manuela Morleo, Helena L.A. Vieira, Petra Pennekamp, Alessandro Palma, Liliana Bento-Lopes, Heymut Omran, Susana S. Lopes, Duarte C. Barral & Brunella Franco. (2023) Crosstalk between cilia and autophagy: implication for human diseases. Autophagy 19:1, pages 24-43.
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Ruoxi Zhang, Rui Kang, Daniel J. Klionsky & Daolin Tang. (2022) Ion Channels and Transporters in Autophagy. Autophagy 18:1, pages 4-23.
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Rajasekharreddy Pala, Ayan K. Barui, Ashraf M. Mohieldin, Jing Zhou & Surya M. Nauli. (2023) Folate conjugated nanomedicines for selective inhibition of mTOR signaling in polycystic kidneys at clinically relevant doses. Biomaterials 302, pages 122329.
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Karla M. Márquez-Nogueras, Virdjinija Vuchkovska & Ivana Y. Kuo. (2023) Calcium signaling in polycystic kidney disease- cell death and survival. Cell Calcium 112, pages 102733.
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Lingfei Luo, Sudipto Roy, Li Li & Ming Ma. (2023) Polycystic kidney disease: novel insights into polycystin function. Trends in Molecular Medicine 29:4, pages 268-281.
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Xuesheng Chu, Xueyan Dai, Wenjing Pu, Huiling Guo, Gang Huang, Bingyan Huang, Ting Cui & Caiying Zhang. (2022) Co‐exposure to molybdenum and cadmium triggers pyroptosis and autophagy by PI3K / AKT axis in duck spleens . Environmental Toxicology 38:3, pages 635-644.
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Xiong Liu, Jingfeng Tang & Xing-Zhen Chen. (2022) Role of PKD2 in the endoplasmic reticulum calcium homeostasis. Frontiers in Physiology 13.
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Karla M. Márquez-Nogueras, Virdjinija Vuchkovska, Elisabeth DiNello, Sara Osorio-Valencia & Ivana Y. Kuo. (2022) Polycystin-2 (PC2) is a key determinant of in vitro myogenesis. American Journal of Physiology-Cell Physiology 323:2, pages C333-C346.
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Carlos Mateluna, Pedro Torres, Marcelo Rodriguez–Peña, Patricio Silva, Douglas J. Matthies, Alfredo Criollo, Floris J. Bikker, Jan G.M. Bolscher, Christian A.M. Wilson, Gerald Zapata–Torres & Vicente A. Torres. (2022) Identification of VEGFR2 as the Histatin-1 receptor in endothelial cells. Biochemical Pharmacology 201, pages 115079.
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Ewud Agborbesong, Linda Xiaoyan Li, Lu Li & Xiaogang Li. (2022) Molecular Mechanisms of Epigenetic Regulation, Inflammation, and Cell Death in ADPKD. Frontiers in Molecular Biosciences 9.
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Wendy N. Sánchez, Luka Robeson, Valentina Carrasco, Nataniel L. Figueroa, Francesca Burgos-Bravo, Christian A. M. Wilson & Nathalie Casanova-Morales. (2022) Determination of protein–protein interactions at the single-molecule level using optical tweezers. Quarterly Reviews of Biophysics 55.
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Jean-Paul Decuypere, Dorien Van Giel, Peter Janssens, Ke Dong, Stefan Somlo, Yiqiang Cai, Djalila Mekahli & Rudi Vennekens. (2021) Interdependent Regulation of Polycystin Expression Influences Starvation-Induced Autophagy and Cell Death. International Journal of Molecular Sciences 22:24, pages 13511.
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Bo Ning, Chuanzhi Guo, Anqi Kong, Kongdong Li, Yimin Xie, Haifeng Shi & Jie Gu. (2021) Calcium Signaling Mediates Cell Death and Crosstalk with Autophagy in Kidney Disease. Cells 10:11, pages 3204.
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Tom Cremer, Jacques Neefjes & Ilana Berlin. (2020) The journey of Ca2+ through the cell – pulsing through the network of ER membrane contact sites. Journal of Cell Science 133:24.
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