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Basic Research

In-vivo evidence of nephrotoxicity and altered hepatic function in rats following administration of diglycolic acid, a metabolite of diethylene glycol

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Pages 196-205 | Received 03 Aug 2016, Accepted 02 Dec 2016, Published online: 11 Jan 2017

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Julie D. Tobin, Courtney N. Jamison, Corie N. Robinson & Kenneth E. McMartin. (2023) Variable sensitivity to diethylene glycol poisoning is related to differences in the uptake transporter for the toxic metabolite diglycolic acid. Clinical Toxicology 61:4, pages 207-211.
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Courtney N. Jamison, Robert D. Dayton, Brian Latimer, Mary P. McKinney, Hannah G. Mitchell & Kenneth E. McMartin. (2022) Diethylene glycol produces nephrotoxic and neurotoxic effects in female rats. Clinical Toxicology 60:3, pages 324-331.
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Courtney N. Jamison, Robert D. Dayton, Brian Latimer, Mary P. McKinney, Hannah G. Mitchell & Kenneth E. McMartin. (2021) Neurotoxic effects of nephrotoxic compound diethylene glycol. Clinical Toxicology 59:9, pages 810-821.
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Steven A. Seifert. (2017) Clinical toxicology: past and future. Clinical Toxicology 55:5, pages 311-312.
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Jon B. Cole, Travis D. Olives, Christian P. J. Lintner, Stacey A. Bangh, Shin K. Kwon & Samuel J. Stellpflug. (2017) A 15-year retrospective review of brake fluid exposures in children from a single poison center. Toxicology Communications 1:1, pages 45-52.
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Articles from other publishers (17)

Grace Malvar, Deepthi Gunasekaran, Nazanin Vaghari Mehr, Shuta Ishibe & Gilbert Moeckel. (2023) Thrombotic Microangiopathy and Acute Tubular Injury After Diethylene Glycol Ingestion: A Kidney Biopsy Teaching Case. Kidney Medicine, pages 100758.
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Stanley de Almeida Araújo, Bárbara Caroline Dias Faria, Júlia Cunha Vasconcelos, Aniel Feitosa da Cruz, Vitor Santos de Souza, David Campos Wanderley & Ana Cristina Simões-e-Silva. (2023) Renal toxicity caused by diethylene glycol: an overview. International Urology and Nephrology.
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Julie D. Tobin, Corie N. Robinson, Elliot S. Luttrell-Williams, Greg M. Landry & Kenneth E. McMartin. (2023) Lack of efflux of diglycolic acid from proximal tubule cells leads to its accumulation and to toxicity of diethylene glycol. Toxicology Letters 379, pages 48-55.
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Kristi J. Reed & Greg M. Landry. (2023) Diglycolic acid inhibits succinate dehydrogenase activity, depletes mitochondrial membrane potential, and induces inflammation in an SH-SY5Y neuroblastoma model of neurotoxicity in vitro. Toxicology and Applied Pharmacology 463, pages 116414.
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Julie D Tobin, Corie N Robinson, Elliot S Luttrell-Williams, Greg M Landry, Donard Dwyer & Kenneth E McMartin. (2022) Role of Plasma Membrane Dicarboxylate Transporters in the Uptake and Toxicity of Diglycolic Acid, a Metabolite of Diethylene Glycol, in Human Proximal Tubule Cells. Toxicological Sciences 190:1, pages 1-12.
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N. Jamison Courtney, K. Cuevas-Ocampo Areli, B. Flowers Ashley, W. Nam Hyung, D. Dayton Robert, P. McKinney Mary, G. Mitchell Hannah, S. Fitzgerald Joseph, E. Steib Mattie, R. Toups Colton & E. McMartin Kenneth. (2022) Histopathological evidence that diethylene glycol produces kidney and nervous system damage in rats. NeuroToxicology 91, pages 200-210.
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Cristiano O L Goulart, Leonardo S Bordoni, Clésia C Nascentes & Letícia M Costa. (2022) Analysis of Diglycolic Acid after Mass Poisoning by Diethylene Glycol. Journal of Analytical Toxicology 46:1, pages 64-68.
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Alan D. Woolf. 2022. History of Modern Clinical Toxicology. History of Modern Clinical Toxicology 139 148 .
Kristi J. Reed, Dylan T. Freeman & Greg M. Landry. (2021) Diethylene glycol and its metabolites induce cell death in SH-SY5Y neuronal cells in vitro. Toxicology in Vitro 75, pages 105196.
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Kirsten Eckstrum, Anneliese Striz, Martine Ferguson, Yang Zhao, Bonnie Welch, Nick Solomotis, Nicholas Olejnik & Robert Sprando. (2020) Utilization of a model hepatotoxic compound, diglycolic acid, to evaluate liver Organ-Chip performance and in vitro to in vivo concordance. Food and Chemical Toxicology 146, pages 111850.
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Chinedu Imo, Ojochenemi E. Yakubu, Nkeiruka G. Imo, Ifeoma S. Udegbun, Silas V. Tatah & Ogochukwu J. Onukwug. (2018) Proximate, Mineral and Phytochemical Composition of Piper guineense Seeds and Leaves. Journal of Biological Sciences 18:7, pages 329-337.
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Jeffrey A. KrautMichael E. Mullins. (2018) Toxic Alcohols. New England Journal of Medicine 378:3, pages 270-280.
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Kenneth E. McMartin. 2018. Mitochondrial Biology and Experimental Therapeutics. Mitochondrial Biology and Experimental Therapeutics 193 211 .
Jeff Fowles, Marcy Banton, Joanna Klapacz & Hua Shen. (2017) A toxicological review of the ethylene glycol series: Commonalities and differences in toxicity and modes of action. Toxicology Letters 278, pages 66-83.
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Robert L. Sprando, Miriam E. Mossoba, Thomas Black, Zachary Keltner, Sanah Vohra, Nicholas Olejnik, Howard Toomer, Cynthia Stine, Eric Evans, Jessica L. Sprando & Martine Ferguson. (2017) 28-day repeated dose response study of diglycolic acid: Renal and hepatic effects. Food and Chemical Toxicology 106, pages 558-567.
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William M. Snellings, Kenneth E. McMartin, Marcy I. Banton, Fred Reitman & Joanna Klapacz. (2017) Human health assessment for long-term oral ingestion of diethylene glycol. Regulatory Toxicology and Pharmacology 87, pages S1-S20.
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Miriam E. Mossoba, Sanah Vohra, Howard Toomer, Shelia Pugh-Bishop, Zachary Keltner, Vanessa Topping, Thomas Black, Nicholas Olejnik, Ana Depina, Kathleen Belgrave, Jessica Sprando, Joyce Njorge, Thomas J. Flynn, Paddy L. Wiesenfeld & Robert L. Sprando. (2017) Comparison of diglycolic acid exposure to human proximal tubule cells in vitro and rat kidneys in vivo. Toxicology Reports 4, pages 342-347.
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