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Clinical Toxicology Volume 56, 2018 - Issue 8
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Magnesium sulfate and calcium channel blocking drugs as antidotes for acute organophosphorus insecticide poisoning – a systematic review and meta-analysis

Miran BrvarPharmacology, Toxicology, and Therapeutics, University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK; ;Centre for Clinical Toxicology and Pharmacology, University Medical Centre Ljubljana, Ljubljana, Slovenia;
,
Ming Yin ChanAccident and Emergency Department, Pamela Youde Nethersole Eastern Hospital, Hong Kong, ROC;
,
Andrew H. DawsonSydney Medical School, University of Sydney, Sydney, Australia; ;South Asian Clinical Toxicology Research Collaboration, University of Peradeniya, Kandy, Sri Lanka;
,
Richard R. RibchesterCentre for Integrated Physiology, University of Edinburgh, Edinburgh, UK
&
Michael EddlestonPharmacology, Toxicology, and Therapeutics, University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK; ;South Asian Clinical Toxicology Research Collaboration, University of Peradeniya, Kandy, Sri Lanka; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-6857-3441
ORCID Icon
Pages 725-736 | Received 19 Jan 2018, Accepted 22 Feb 2018, Published online: 20 Mar 2018

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Fazle Rabbi Chowdhury, Suvodip Shaw, Abdullah Abu Sayeed, Soumitra Roy, Abu Shahin Mohammad Mahbubur Rahman, Nahida Zafrin, Pritish Tarafder, Muhammad Halimur Rashid, Aniruddha Ghose, Shishir Ranjan Chakraborty, Muhammad Khalilur Rahman, Muhammad Sayedur Rahman, Richard Parker, Muhammad Mahib Ullah, Zakir Hassan, Abdullah Al Mamun Sohag, Muhammad Robed Amin, Muhammad Shafiqul Bari, John Norrie, M. A. Faiz & Michael Eddleston. (2023) Effectiveness of calcium channel blockade for organophosphorus and carbamate pesticide poisoning – study protocol for an open label, pragmatic, 3-arm RCT repurposing two widely available medicines. Toxicology Communications 7:1.
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Ashok Kumar Pannu, Sahil Garg, Ashish Bhalla, Deba Prasad Dhibar & Navneet Sharma. (2022) Lipid emulsion for the treatment of acute organophosphate poisoning: an Open-Label randomized trial. Clinical Toxicology 60:5, pages 602-608.
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Kosala N. Dissanayake, Robert Chang-Chih Chou, Adrian Thompson, Filip Margetiny, Charlotte Davie, Scott McKinnon, Vishwendra Patel, Lester Sultatos, Joseph J. McArdle, Richard E. Clutton, Michael Eddleston & Richard R. Ribchester. (2021) Impaired neuromuscular function by conjoint actions of organophosphorus insecticide metabolites omethoate and cyclohexanol with implications for treatment of respiratory failure. Clinical Toxicology 59:12, pages 1239-1258.
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Maria Alozi & Mutasem Rawas-Qalaji. (2020) Treating organophosphates poisoning: management challenges and potential solutions. Critical Reviews in Toxicology 50:9, pages 764-779.
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Articles from other publishers (24)

Samaneh Hajimohammadi, Mahdi Balali-Mood, Leila Etemad & Mohammad Moshiri. 2024. Encyclopedia of Toxicology. Encyclopedia of Toxicology 707 725 .
Christy Turco & Sidhartha D. Ray. 2024. Encyclopedia of Toxicology. Encyclopedia of Toxicology 591 601 .
Jayanta Kumar Mitra, Upendra Hansda, Debapriya Bandyopadhyay, Satyaki Sarkar & Joshna Sahoo. (2023) The role of a combination of N-acetylcysteine and magnesium sulfate as adjuvants to standard therapy in acute organophosphate poisoning: A randomized controlled trial. Heliyon 9:4, pages e15376.
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Martin J Morales-Cruz, Bridget Scheveck, Vanessa I Diaz, Keegan S McNally, Jennifer Elfman & Latha Ganti. (2023) Organophosphate Toxicity Presenting as a Stroke Alert. Cureus.
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Maciej Noga, Agata Michalska & Kamil Jurowski. (2023) Review of Possible Therapies in Treatment of Novichoks Poisoning and HAZMAT/CBRNE Approaches: State of the Art. Journal of Clinical Medicine 12:6, pages 2221.
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Hany H. Arab, Ali Khames, Shuruq E. Alsufyani, Azza A. K. El-Sheikh & Amany M. Gad. (2023) Targeting the Endoplasmic Reticulum Stress-Linked PERK/GRP78/CHOP Pathway with Magnesium Sulfate Attenuates Chronic-Restraint-Stress-Induced Depression-like Neuropathology in Rats. Pharmaceuticals 16:2, pages 300.
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F Uys, M O’Neill, Z Farina & J Belford. (2023) Case Report. South African Medical Journal, pages 57-60.
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Amirhosein Charejoo, Masoud Arabfard, Amir Jafari & Yazdan Hasani Nourian. (2023) A complete, evidence-based review on novichok poisoning based on epidemiological aspects and clinical management. Frontiers in Toxicology 4.
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Mutasem Rawas-Qalaji, Hnin Ei Thu & Zahid Hussain. 2023. Sensing of Deadly Toxic Chemical Warfare Agents, Nerve Agent Simulants, and their Toxicological Aspects. Sensing of Deadly Toxic Chemical Warfare Agents, Nerve Agent Simulants, and their Toxicological Aspects 539 568 .
Lenka Pulkrabkova, Barbora Svobodova, Jan Konecny, Tereza Kobrlova, Lubica Muckova, Jiri Janousek, Jaroslav Pejchal, Jan Korabecny & Ondrej Soukup. (2022) Neurotoxicity evoked by organophosphates and available countermeasures. Archives of Toxicology 97:1, pages 39-72.
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Elisabeth Wigenstam, Elisabet Artursson, Anders Bucht & Lina Thors. (2022) Supplemental treatment to atropine improves the efficacy to reverse nerve agent induced bronchoconstriction. Chemico-Biological Interactions 364, pages 110061.
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Kosala N. Dissanayake, Robert R. Redman, Harry Mackenzie, Michael Eddleston & Richard R. Ribchester. (2022) “Calcium bombs” as harbingers of synaptic pathology and their mitigation by magnesium at murine neuromuscular junctions. Frontiers in Molecular Neuroscience 15.
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HMohan Kumar, AshokKumar Pannu, Susheel Kumar, Navneet Sharma & Ashish Bhalla. (2022) Magnesium sulfate in organophosphorus compound poisoning: A prospective open-label clinician-initiated intervention trial with historical controls. International Journal of Critical Illness and Injury Science 12:1, pages 33.
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Gentle Sunder Shrestha, Gaurav Nepal & Rajeev Ojha. 2022. Emergencies in Neuromuscular Disorders. Emergencies in Neuromuscular Disorders 393 424 .
S.V. Kursov, V.V. Nikonov, O.V. Biletskyi, O.E. Feskov & S.M. Skoroplit. (2021) Physiology of magnesium metabolism and the use of magnesium in intensive care (part 2). EMERGENCY MEDICINE 17:6, pages 17-27.
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S.V. Kursov, V.V. Nikonov, O.V. Biletskyi, O.I. Fedets & V.O. Homenko. (2021) Physiology of magnesium metabolism and the use of magnesium in intensive care (literature review with the results of own observations, part 1). EMERGENCY MEDICINE 17:5, pages 56-67.
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Sakib Aman, Shrebash Paul & Fazle Rabbi Chowdhury. (2021) Management of Organophosphorus Poisoning. Critical Care Clinics 37:3, pages 673-686.
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Hafiz Ubaid ur Rahman, Waqas Asghar, Wahab Nazir, Mansur Abdullah Sandhu, Anwaar Ahmed & Nauman Khalid. (2021) A comprehensive review on chlorpyrifos toxicity with special reference to endocrine disruption: Evidence of mechanisms, exposures and mitigation strategies. Science of The Total Environment 755, pages 142649.
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Amira M. Badr. (2020) Organophosphate toxicity: updates of malathion potential toxic effects in mammals and potential treatments. Environmental Science and Pollution Research 27:21, pages 26036-26057.
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Shi-yuan Yu, Yan-xia Gao, Joseph Walline, Xin Lu, Li-na Zhao, Yuan-xu Huang, Jiang Tao, An-yong Yu, Na Ta, Ren-ju Xiao & Yi Li. (2020) Role of penehyclidine in acute organophosphorus pesticide poisoning. World Journal of Emergency Medicine 11:1, pages 37.
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Michiko Higashi, Takahiro Tamura & Yushi U. Adachi. (2019) Prolonged neuromuscular blockade by non-depolarizing neuromuscular blocking agents. JA Clinical Reports 5:1.
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Dong-Dong Zhang, Jing-Min Liu, Shi-Ming Sun, Chang Liu, Guo-Zhen Fang & Shuo Wang. (2019) Construction of Persistent Luminescence-Plastic Antibody Hybrid Nanoprobe for In Vivo Recognition and Clearance of Pesticide Using Background-Free Nanobioimaging. Journal of Agricultural and Food Chemistry 67:24, pages 6874-6883.
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Michael Eddleston. (2019) Novel Clinical Toxicology and Pharmacology of Organophosphorus Insecticide Self-Poisoning. Annual Review of Pharmacology and Toxicology 59:1, pages 341-360.
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Jayanta Kumar Mitra, Upendra Hansda, Debapriya Bandyopadhyay, Satyaki Sarkar & Joshna Sahoo. (2022) The Role of a Combination of N-Acetylcysteine and Magnesium Sulfate as Adjuvants to Standard Therapy in Acute Organophosphate Poisoning: A Randomized Controlled Trial. SSRN Electronic Journal.
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