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Epigenetics Volume 12, 2017 - Issue 9
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Research Paper

A MBD-seq protocol for large-scale methylome-wide studies with (very) low amounts of DNA

Karolina A. AbergCenter for Biomarker Research and Precision Medicine, Virginia Commonwealth University, Richmond, VA, USACorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0001-6103-5168View further author information
ORCID Icon,
Robin F. ChanCenter for Biomarker Research and Precision Medicine, Virginia Commonwealth University, Richmond, VA, USAView further author information
,
Andrey A. ShabalinCenter for Biomarker Research and Precision Medicine, Virginia Commonwealth University, Richmond, VA, USAView further author information
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Min ZhaoCenter for Biomarker Research and Precision Medicine, Virginia Commonwealth University, Richmond, VA, USAView further author information
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Gustavo TureckiDouglas Mental Health University Institute and Department of Psychiatry, McGill University, Montreal, Quebec, CanadaView further author information
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Nicklas Heine StaunstrupDepartment of Biomedicine, Aarhus University, Aarhus C, 8000, Denmark;Translational Neuropsychiatric Unit, Aarhus University Hospital, Risskov, 8240, Denmark;The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark;Center for Integrative Sequencing, iSEQ, Aarhus University, Aarhus C, 8000, DenmarkView further author information
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Anna StarnawskaDepartment of Biomedicine, Aarhus University, Aarhus C, 8000, Denmark;The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark;Center for Integrative Sequencing, iSEQ, Aarhus University, Aarhus C, 8000, DenmarkView further author information
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Ole MorsTranslational Neuropsychiatric Unit, Aarhus University Hospital, Risskov, 8240, Denmark;Psychosis Research Unit, Aarhus University Hospital, Risskov, 8240, Denmark;The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, DenmarkView further author information
,
Lin Y. XieCenter for Biomarker Research and Precision Medicine, Virginia Commonwealth University, Richmond, VA, USAView further author information
&
Edwin JCG van den OordCenter for Biomarker Research and Precision Medicine, Virginia Commonwealth University, Richmond, VA, USAView further author information
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Pages 743-750 | Received 14 Apr 2017, Accepted 22 May 2017, Published online: 06 Nov 2017

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Jinyong Huang, Alex C. Soupir & Liang Wang. (2022) Cell-free DNA methylome profiling by MBD-seq with ultra-low input. Epigenetics 17:3, pages 239-252.
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Karolina A. Aberg, Robin F. Chan & Edwin J. C. G. van den Oord. (2020) MBD-seq - realities of a misunderstood method for high-quality methylome-wide association studies. Epigenetics 15:4, pages 431-438.
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Articles from other publishers (31)

John M. Hettema, Edwin J. C. G. van den Oord, Min Zhao, Lin Y. Xie, William E. Copeland, Brenda W. J. H. Penninx, Karolina A. Aberg & Shaunna L. Clark. (2023) Methylome-wide association study of anxiety disorders. Molecular Psychiatry 28:8, pages 3484-3492.
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Emily Gruber, Alexander C. Lewis & Lev M. Kats. 2023. Precision Cancer Therapies, Volume 1 ‐ Targeting Oncogenic Drivers and Signaling Pathways in Lymphoid Malignancies. Precision Cancer Therapies, Volume 1 ‐ Targeting Oncogenic Drivers and Signaling Pathways in Lymphoid Malignancies 209 224 .
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William E. Copeland, Lilly Shanahan, Ellen W. McGinnis, Karolina A. Aberg & Edwin J.C.G. van den Oord. (2022) Early adversities accelerate epigenetic aging into adulthood: a 10‐year, within‐subject analysis. Journal of Child Psychology and Psychiatry 63:11, pages 1308-1315.
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Charlie L. J. D. van den Oord, William E. Copeland, Min Zhao, Lin Ying Xie, Karolina A. Aberg & Edwin J. C. G. van den Oord. (2022) DNA methylation signatures of childhood trauma predict psychiatric disorders and other adverse outcomes 17 years after exposure. Molecular Psychiatry 27:8, pages 3367-3373.
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Shaunna L. Clark, Robin F. Chan, Min Zhao, Lin Y. Xie, William E. Copeland, Brenda W. J. H. Penninx, Karolina A. Aberg & Edwin J. C. G. van den Oord. (2021) Dual methylation and hydroxymethylation study of alcohol use disorder. Addiction Biology 27:2.
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Edwin J. C. G. van den Oord, Lin Y. Xie, Charles J. Tran, Min Zhao & Karolina A. Aberg. (2021) A targeted solution for estimating the cell-type composition of bulk samples. BMC Bioinformatics 22:1.
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Huiyan Luo, Wei Wei, Ziyi Ye, Jiabo Zheng & Rui-hua Xu. (2021) Liquid Biopsy of Methylation Biomarkers in Cell-Free DNA. Trends in Molecular Medicine 27:5, pages 482-500.
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Robin F. Chan, Gustavo Turecki, Andrey A. Shabalin, Jerry Guintivano, Min Zhao, Lin Y. Xie, Gerard van Grootheest, Zachary A. Kaminsky, Brian Dean, Brenda W.J.H. Penninx, Karolina A. Aberg & Edwin J.C.G. van den Oord. (2020) Cell Type–Specific Methylome-wide Association Studies Implicate Neurotrophin and Innate Immune Signaling in Major Depressive Disorder. Biological Psychiatry 87:5, pages 431-442.
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Huang & Wang. (2019) Cell-Free DNA Methylation Profiling Analysis—Technologies and Bioinformatics. Cancers 11:11, pages 1741.
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Robin F Chan, Andrey A Shabalin, Carolina Montano, Eilis Hannon, Christina M Hultman, Margaret D Fallin, Andrew P Feinberg, Jonathan Mill, Edwin J C G van den Oord & Karolina A Aberg. (2019) Independent Methylome-Wide Association Studies of Schizophrenia Detect Consistent Case–Control Differences. Schizophrenia Bulletin.
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Claudius Grehl, Markus Kuhlmann, Claude Becker, Bruno Glaser & Ivo Grosse. (2018) How to Design a Whole-Genome Bisulfite Sequencing Experiment. Epigenomes 2:4, pages 21.
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Karolina A. Aberg, Andrey A. Shabalin, Robin F. Chan, Min Zhao, Gaurav Kumar, Gerard van Grootheest, Shaunna L. Clark, Lin Y. Xie, Yuri Milaneschi, Brenda W. J. H. Penninx & Edwin J. C. G. van den Oord. (2018) Convergence of evidence from a methylome-wide CpG-SNP association study and GWAS of major depressive disorder. Translational Psychiatry 8:1.
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Andrey A Shabalin, Mohammad W Hattab, Shaunna L Clark, Robin F Chan, Gaurav Kumar, Karolina A Aberg & Edwin J C G van den Oord. (2018) RaMWAS: fast methylome-wide association study pipeline for enrichment platforms. Bioinformatics 34:13, pages 2283-2285.
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