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Epigenetics Volume 14, 2019 - Issue 8
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Research Paper

Epigenome-wide DNA methylation in placentas from preterm infants: association with maternal socioeconomic status

Hudson P. Santos JrSchool of Nursing, University of North Carolina, Chapel Hill, NC, USA;Institute for Environmental Health Solutions, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USACorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-4040-366XView further author information
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Arjun BhattacharyaDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USAORCID Iconhttp://orcid.org/0000-0003-1196-4385View further author information
ORCID Icon,
Elizabeth M. MartinCurriculum in Toxicology and Environmental Medicine, University of North Carolina, Chapel Hill, NC, USAView further author information
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Kezia AddoCurriculum in Toxicology and Environmental Medicine, University of North Carolina, Chapel Hill, NC, USA;Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USAView further author information
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Matt PsiodaDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USAView further author information
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Lisa SmeesterInstitute for Environmental Health Solutions, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA;Curriculum in Toxicology and Environmental Medicine, University of North Carolina, Chapel Hill, NC, USA;Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USAView further author information
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Robert M. JosephDepartment of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USAView further author information
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Stephen R. HooperDepartment of Allied Health Sciences, School of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USAView further author information
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Jean A. FrazierEunice Kennedy Shriver Center, University of Massachusetts Medical School, Worcester, MA, USA;Department of Psychiatry, University of Massachusetts Medical School/University of Massachusetts Memorial Health Care, Worcester, MA, USAORCID Iconhttp://orcid.org/0000-0001-7055-3530View further author information
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Karl C. KubanDepartment of Pediatrics, Division of Pediatric Neurology, Boston University Medical Center, Boston, MA, USAView further author information
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T.Michael O’SheaDepartment of Pediatrics, School of Medicine, University of North Carolina, Chapel Hill, NC, USAORCID Iconhttp://orcid.org/0000-0001-6692-911XView further author information
ORCID Icon &
Rebecca C. FryInstitute for Environmental Health Solutions, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA;Curriculum in Toxicology and Environmental Medicine, University of North Carolina, Chapel Hill, NC, USA;Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USAView further author information
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Pages 751-765 | Received 01 Feb 2019, Accepted 26 Apr 2019, Published online: 21 May 2019

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Jeliyah Clark, Catherine M. Bulka, Chantel L. Martin, Kyle Roell, Hudson P. Santos, T. Michael O’Shea, Lisa Smeester, Rebecca Fry & Radhika Dhingra. (2022) Placental epigenetic gestational aging in relation to maternal sociodemographic factors and smoking among infants born extremely preterm: a descriptive study. Epigenetics 17:13, pages 2389-2403.
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Gang Li, Laura Raffield, Mark Logue, Mark W. Miller, Hudson P. Santos$suffix/text()$suffix/text(), T. Michael O’Shea, Rebecca C. Fry & Yun Li. (2021) CUE: CpG impUtation ensemble for DNA methylation levels across the human methylation450 (HM450) and EPIC (HM850) BeadChip platforms. Epigenetics 16:8, pages 851-861.
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Moshe Szyf. (2019) The epigenetics of perinatal stress
. Dialogues in Clinical Neuroscience 21:4, pages 369-378.
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Jeliyah Clark, Elizabeth Martin, Catherine M. Bulka, Lisa Smeester, Hudson P. Santos, T.Michael O’Shea & Rebecca C. Fry. (2019) Associations between placental CpG methylation of metastable epialleles and childhood body mass index across ages one, two and ten in the Extremely Low Gestational Age Newborns (ELGAN) cohort. Epigenetics 14:11, pages 1102-1111.
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Articles from other publishers (35)

Cavin Ward-Caviness, William E. Kraus, Radhika Dhingra, Chantel L. Martin, Andres Cardenas, Jamaji Nwanaji-Enwerem & Wayne E. Cascio. 2024. Comprehensive Precision Medicine. Comprehensive Precision Medicine 413 429 .
Jane W. Y. Ng, Janine F. Felix & David M. Olson. (2023) A novel approach to risk exposure and epigenetics—the use of multidimensional context to gain insights into the early origins of cardiometabolic and neurocognitive health. BMC Medicine 21:1.
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Harry Adynski, Cathi Propper, Linda Beeber, John H. Gilmore, Baiming Zou & Hudson P. SantosJrJr. (2023) The role of social adversity on emotional dysregulation during infancy and early childhood. Journal of Pediatric Nursing 72, pages 26-35.
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Hudson P. SantosJr.Jr., Adam E. Enggasser, Jeliyah Clark, Kyle Roell, Vasyl Zhabotynsky, William Adam Gower, Diana Yanni, Nou Gao Yang, Lisa Washburn, Semsa Gogcu, Carmen J. Marsit, Karl Kuban, T. Michael O’Shea & Rebecca C. Fry. (2023) Sexually dimorphic methylation patterns characterize the placenta and blood from extremely preterm newborns. BMC Biology 21:1.
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Anastasia N. Freedman, Jeliyah Clark, Lauren A. Eaves, Kyle Roell, Ali Oran, Lauren Koval, Julia Rager, Hudson P. SantosJr.Jr., Karl Kuban, Robert M. Joseph, Jean Frazier, Carmen J. Marsit, Amber A. Burt, T. Michael O'Shea & Rebecca C. Fry. (2023) A multi‐omic approach identifies an autism spectrum disorder ( ASD ) regulatory complex of functional epimutations in placentas from children born preterm . Autism Research 16:5, pages 918-934.
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Jianhong Chen, Mark D. Long, Sirinapa Sribenja, Sung Jun Ma, Li Yan, Qiang Hu, Song Liu, Thaer Khoury, Chi-Chen Hong, Elisa Bandera, Anurag K. Singh, Elizabeth A. Repasky, Elizabeth G. Bouchard, Michael Higgins, Christine B. Ambrosone & Song Yao. (2023) An epigenome-wide analysis of socioeconomic position and tumor DNA methylation in breast cancer patients. Clinical Epigenetics 15:1.
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T. Michael O’Shea, Monica McGrath, Judy L. Aschner, Barry Lester, Hudson P. SantosJrJr, Carmen Marsit, Annemarie Stroustrup, Crisma Emmanuel, Mark Hudak, Elisabeth McGowan, Simran Patel, Rebecca C. Fry, P. B. Smith, K. L. Newby, L. P. Jacobson & C. B. Parker. (2022) Environmental influences on child health outcomes: cohorts of individuals born very preterm. Pediatric Research 93:5, pages 1161-1176.
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Lauren A. Eaves, Adam E. Enggasser, Marie Camerota, Semsa Gogcu, William A. Gower, Hadley Hartwell, Wesley M. Jackson, Elizabeth Jensen, Robert M. Joseph, Carmen J. Marsit, Kyle Roell, Hudson P. Santos, Jeffrey S. Shenberger, Lisa Smeester, Diana Yanni, Karl C. K. Kuban, T. Michael O’Shea & Rebecca C. Fry. (2022) CpG methylation patterns in placenta and neonatal blood are differentially associated with neonatal inflammation. Pediatric Research 93:4, pages 1072-1084.
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Lauren A. Eaves, Catherine M. Bulka, Julia E. Rager, Amaree J. Gardner, Aubrey L. Galusha, Patrick J. Parsons, T. Michael O'Shea & Rebecca C. Fry. (2023) Metal mixtures modeling identifies birth weight-associated gene networks in the placentas of children born extremely preterm. Chemosphere 313, pages 137469.
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Meghna Rajaprakash, Lorraine T Dean, Meredith Palmore, Sara B Johnson, Joan Kaufman, Daniele M Fallin & Christine Ladd-Acosta. (2023) DNA methylation signatures as biomarkers of socioeconomic position. Environmental Epigenetics 9:1.
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Michael Mortillo & Carmen J. Marsit. (2022) Select Early-Life Environmental Exposures and DNA Methylation in the Placenta. Current Environmental Health Reports 10:1, pages 22-34.
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Carmen Amelia Marable, Kyle Roell, Karl Kuban, T. Michael O’Shea & Rebecca C. Fry. (2022) Placental transcriptional signatures associated with cerebral white matter damage in the neonate. Frontiers in Neuroscience 16.
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Robert M. Joseph, Stephen R. Hooper, Tim Heeren, Hudson P. SantosJrJr, Jean A. Frazier, Lauren Venuti, Ann Foley, Caitlin K. Rollins, Karl C. K. Kuban, Rebecca C. Fry & Thomas M. O’Shea. (2022) Maternal social risk, gestational age at delivery, and cognitive outcomes among adolescents born extremely preterm. Paediatric and Perinatal Epidemiology 36:5, pages 654-664.
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Ronan Adler Tavella, Flavia Saraçol Vignol, Rafael Frizzo Favero, Tatiane Britto da Silveira, Marina dos Santos, Edariane Menestrino Garcia & Flavio Manoel Rodrigues da Silva Júnior. (2022) DNA damage in Brazilian newborns admitted to NICUs - association with maternal and neonatal outcomes. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 881, pages 503521.
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Rose Schrott, Ashley Song & Christine Ladd-Acosta. (2022) Epigenetics as a Biomarker for Early-Life Environmental Exposure. Current Environmental Health Reports 9:4, pages 604-624.
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Wesley M. Jackson, Hudson P. SantosJrJr, Hadley J. Hartwell, William Adam Gower, Divya Chhabra, James S. Hagood, Matthew M. Laughon, Alexis Payton, Lisa Smeester, Kyle Roell, T. Michael O’Shea & Rebecca C. Fry. (2021) Differential placental CpG methylation is associated with chronic lung disease of prematurity. Pediatric Research 91:6, pages 1428-1435.
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Samantha Lapehn & Alison G. Paquette. (2022) The Placental Epigenome as a Molecular Link Between Prenatal Exposures and Fetal Health Outcomes Through the DOHaD Hypothesis. Current Environmental Health Reports 9:3, pages 490-501.
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Chantel L. Martin, Lea GhastineEvans K. Lodge, Radhika Dhingra & Cavin K. Ward-Caviness. (2022) Understanding Health Inequalities Through the Lens of Social Epigenetics. Annual Review of Public Health 43:1, pages 235-254.
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Yun Zhang & Chunyu Liu. (2022) Evaluating the challenges and reproducibility of studies investigating DNA methylation signatures of psychological stress. Epigenomics 14:7, pages 405-421.
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Celina I. Valencia, Francine C. Gachupin, Yamilé Molina & Ken Batai. (2022) Interrogating Patterns of Cancer Disparities by Expanding the Social Determinants of Health Framework to Include Biological Pathways of Social Experiences. International Journal of Environmental Research and Public Health 19:4, pages 2455.
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Arjun Bhattacharya, Anastasia N. Freedman, Vennela Avula, Rebeca Harris, Weifang Liu, Calvin Pan, Aldons J. Lusis, Robert M. Joseph, Lisa Smeester, Hadley J. Hartwell, Karl C. K. Kuban, Carmen J. Marsit, Yun Li, T. Michael O’Shea, Rebecca C. Fry & Hudson P. SantosJrJr. (2022) Placental genomics mediates genetic associations with complex health traits and disease. Nature Communications 13:1.
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Genevieve L. Taylor & T. Michael O'Shea. (2022) Extreme prematurity: Risk and resiliency. Current Problems in Pediatric and Adolescent Health Care 52:2, pages 101132.
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Janine Cerutti, Alexandre A. Lussier, Yiwen Zhu, Jiaxuan Liu & Erin C. Dunn. (2021) Associations between indicators of socioeconomic position and DNA methylation: a scoping review. Clinical Epigenetics 13:1.
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Ai-ris Y Collier, Rachel Ledyard, Diana Montoya-Williams, Maylene Qiu, Alexandra E Dereix, Minou Raschid Farrokhi, Michele R Hacker & Heather H Burris. (2021) Racial and ethnic representation in epigenomic studies of preterm birth: a systematic review. Epigenomics 13:21, pages 1735-1746.
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Pan Zhang, Olivia C. Perez, Bruce R. Southey, Jonathan V. Sweedler, Amynah A. Pradhan & Sandra L. Rodriguez-Zas. (2021) Alternative Splicing Mechanisms Underlying Opioid-Induced Hyperalgesia. Genes 12:10, pages 1570.
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Jeliyah Clark, Vennela Avula, Caroline Ring, Lauren A Eaves, Thomas Howard, Hudson P SantosJrJr, Lisa Smeester, Jacqueline T Bangma, Thomas Michael O’Shea, Rebecca C Fry & Julia E Rager. (2021) Comparing the Predictivity of Human Placental Gene, microRNA, and CpG Methylation Signatures in Relation to Perinatal Outcomes. Toxicological Sciences 183:2, pages 269-284.
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Xiumei Hong, Tami R. Bartell & Xiaobin Wang. (2020) Gaining a deeper understanding of social determinants of preterm birth by integrating multi-omics data. Pediatric Research 89:2, pages 336-343.
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Jacqueline T. Bangma, Hadley Hartwell, Hudson P. SantosJr.Jr., T. Michael O’Shea & Rebecca C. Fry. (2020) Placental programming, perinatal inflammation, and neurodevelopment impairment among those born extremely preterm. Pediatric Research 89:2, pages 326-335.
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Hudson P. Santos Jr, Arjun Bhattacharya, Robert M. Joseph, Lisa Smeester, Karl C. K. Kuban, Carmen J. Marsit, T. Michael O’Shea & Rebecca C. Fry. (2020) Evidence for the placenta-brain axis: multi-omic kernel aggregation predicts intellectual and social impairment in children born extremely preterm. Molecular Autism 11:1.
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Aleksandra Stanković. 2020. DNA Methylation Mechanism. DNA Methylation Mechanism.
Marine Poullet & Ludovic Orlando. (2020) Assessing DNA Sequence Alignment Methods for Characterizing Ancient Genomes and Methylomes. Frontiers in Ecology and Evolution 8.
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Michael G. Gottschalk, Katharina Domschke & Miriam A. Schiele. (2020) Epigenetics Underlying Susceptibility and Resilience Relating to Daily Life Stress, Work Stress, and Socioeconomic Status. Frontiers in Psychiatry 11.
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Isabel Benavente-Fernández, Arjumand Siddiqi & Steven P. Miller. (2019) Socioeconomic status and brain injury in children born preterm: modifying neurodevelopmental outcome. Pediatric Research 87:2, pages 391-398.
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Katie Kerr, Helen McAneney, Cheryl Flanagan, Alexander P. Maxwell & Amy Jayne McKnight. (2019) Differential methylation as a diagnostic biomarker of rare renal diseases: a systematic review. BMC Nephrology 20:1.
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Lauren A. Eaves, Catherine M. Bulka, Julia E. Rager, Aubrey L. Galusha, Patrick J. Parsons, Thomas Michael O'Shea & Rebecca C. Fry. (2022) Metals Mixtures Modeling Identifies Birth Weight-Associated Gene Networks in the Placentas of Children Born Extremely Preterm. SSRN Electronic Journal.
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