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Expert Opinion on Drug Metabolism & Toxicology Volume 17, 2021 - Issue 8: Alternatives to Animal Models in Toxicology
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Review

Novel test strategies for in vitro seizure liability assessment

Anke M. Tukkera School of Health Sciences, Purdue University, Hall for Discovery and Learning Research (DLR 339), INUSAORCID Iconhttps://orcid.org/0000-0001-8973-4809View further author information
ORCID Icon &
Remco H. S. Westerinkb Neurotoxicology Research Group, Toxicology Division, Institute for Risk Assessment Sciences (IRAS), Faculty of Veterinary Medicine, Utrecht University, TD Utrecht, The NetherlandsCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-4948-2007View further author information
ORCID Icon
Pages 923-936 | Received 03 Nov 2020, Accepted 11 Jan 2021, Published online: 17 Feb 2021

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Elisa Giovannetti & Godefridus Peters. (2021) Beyond animal models: implementing the 3Rs principles and improving pharmacological studies with new model systems. Expert Opinion on Drug Metabolism & Toxicology 17:8, pages 867-868.
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Articles from other publishers (5)

Genhao Fan, Menglin Liu, Jia Liu & Yuhong Huang. (2023) The initiator of neuroexcitotoxicity and ferroptosis in ischemic stroke: Glutamate accumulation. Frontiers in Molecular Neuroscience 16.
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Hua-Rong Lu, Manabu Seo, Mohamed Kreir, Tetsuya Tanaka, Rie Yamoto, Cristina Altrocchi, Karel van Ammel, Fetene Tekle, Ly Pham, Xiang Yao, Ard Teisman & David J. Gallacher. (2023) High-Throughput Screening Assay for Detecting Drug-Induced Changes in Synchronized Neuronal Oscillations and Potential Seizure Risk Based on Ca2+ Fluorescence Measurements in Human Induced Pluripotent Stem Cell (hiPSC)-Derived Neuronal 2D and 3D Cultures. Cells 12:6, pages 958.
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Ropafadzo Mzezewa, Johanna Lotila, Heikki Kiiski, Andrey Vinogradov, Fikret Emre Kapucu, Jukka Peltola, Sanna Hagman & Susanna Narkilahti. (2022) A kainic acid-induced seizure model in human pluripotent stem cell-derived cortical neurons for studying the role of IL-6 in the functional activity. Stem Cell Research 60, pages 102665.
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Helena T. Hogberg & Lena Smirnova. (2022) The Future of 3D Brain Cultures in Developmental Neurotoxicity Testing. Frontiers in Toxicology 4.
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Nadine Euskirchen, Michael A. Nitsche & Christoph van Thriel. (2021) Direct Current Stimulation in Cell Culture Systems and Brain Slices—New Approaches for Mechanistic Evaluation of Neuronal Plasticity and Neuromodulation: State of the Art. Cells 10:12, pages 3583.
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