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Editorial

Minipigs as models in drug discovery

, &
Pages 1131-1134 | Received 13 Jun 2016, Accepted 08 Aug 2016, Published online: 22 Aug 2016

Keep up to date with the latest research on this topic with citation updates for this article.

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Yingying Du, Jianmin Fang, Ming Liang, Zumeng Xia, Jieyi Long, Tao Peng & Xiaoliang Lin. (2023) Immune modulatory effects of food supplement products Zeng Jian Heath Tonic and Zhen Yuan Capsule in elderly mice. CyTA - Journal of Food 21:1, pages 433-441.
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Kristine Langthaler, Christopher R. Jones, Rasmus B. Christensen, Elin Eneberg, Birger Brodin & Christoffer Bundgaard. (2022) Characterisation of intravenous pharmacokinetics in Göttingen minipig and clearance prediction using established in vitro to in vivo extrapolation methodologies. Xenobiotica 52:6, pages 591-607.
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Kristine Langthaler, Christopher R. Jones, Birger Brodin & Christoffer Bundgaard. (2023) Assessing extent of brain penetration in vivo (Kp,uu,brain) in Göttingen minipig using a diverse set of reference drugs. European Journal of Pharmaceutical Sciences 190, pages 106554.
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Luyao Wang, Yuexian Piao, Fucheng Guo, Jiarui Wei, Yurong Chen, Xiangpeng Dai & Xiaoling Zhang. (2023) Current progress of pig models for liver cancer research. Biomedicine & Pharmacotherapy 165, pages 115256.
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Sarah E. Lindley, Yiyang Lu & Diwakar Shukla. (2023) The Experimentalist’s Guide to Machine Learning for Small Molecule Design. ACS Applied Bio Materials.
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Alexandre A. Vetcher, Kirill V. Zhukov, Bagrat A. Gasparyan, Pavel I. Borovikov, Arfenia S. Karamian, Dovlet T. Rejepov, Maria N. Kuznetsova & Alexander Y. Shishonin. (2023) Different Trajectories for Diabetes Mellitus Onset and Recovery According to the Centralized Aerobic–Anaerobic Energy Balance Compensation Theory. Biomedicines 11:8, pages 2147.
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Marina-Stefania Stroe, Lieselotte Van Bockstal, Allan Valenzuela, Miriam Ayuso, Karen Leys, Pieter Annaert, Sebastien Carpentier, Anne Smits, Karel Allegaert, Adrian Zeltner, Antonius Mulder, Chris Van Ginneken & Steven Van Cruchten. (2023) Development of a neonatal Göttingen Minipig model for dose precision in perinatal asphyxia: technical opportunities, challenges, and potential further steps. Frontiers in Pediatrics 11.
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Saravanakumar Selvaraj, Jung-Hwa Oh, Seokjoo Yoon & Jürgen Borlak. (2023) Diclofenac Disrupts the Circadian Clock and through Complex Cross-Talks Aggravates Immune-Mediated Liver Injury—A Repeated Dose Study in Minipigs for 28 Days. International Journal of Molecular Sciences 24:2, pages 1445.
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Max Karlsson, Evelina Sjöstedt, Per Oksvold, Åsa Sivertsson, Jinrong Huang, María Bueno Álvez, Muhammad Arif, Xiangyu Li, Lin Lin, Jiaying Yu, Tao Ma, Fengping Xu, Peng Han, Hui Jiang, Adil Mardinoglu, Cheng Zhang, Kalle von Feilitzen, Xun Xu, Jian Wang, Huanming Yang, Lars Bolund, Wen Zhong, Linn Fagerberg, Cecilia Lindskog, Fredrik Pontén, Jan Mulder, Yonglun Luo & Mathias Uhlen. (2022) Genome-wide annotation of protein-coding genes in pig. BMC Biology 20:1.
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Zhukov Kirill V, Gasparyan Bagrat A, Vetcher Alexandre A & Shishonin Alexander Y. (2022) Left ventricular hypertrophy linked with arterial hypertension through centralized aerobic-anaerobic energy balance compensation theory. Annals of Clinical Hypertension 6:1, pages 012-014.
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Zhukov Kirill V, Gasparuan Bagrat A, Vetcher Alexandre A & Shishonin Alexander Y. (2022) Centralized aerobic-anaerobic energy balance compensation theory perspective in biomedicine. Archives of Biotechnology and Biomedicine 6:1, pages 007-009.
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Trine Pagh Ludvigsen, Lisbeth Høier Olsen, Henrik Duelund Pedersen, Berit Østergaard Christoffersen & Lars Jørn Jensen. (2019) Hyperglycemia-induced transcriptional regulation of ROCK1 and TGM2 expression is involved in small artery remodeling in obese diabetic Göttingen Minipigs. Clinical Science 133:24, pages 2499-2516.
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Francesca L. Wood, Sam Shepherd, Angela Hayes, Manjuan Liu, Katia Grira, Yi Mok, Butrus Atrash, Amir Faisal, Vassilios Bavetsias, Spiros Linardopoulos, Julian Blagg & Florence I. Raynaud. (2019) Metabolism of the dual FLT-3/Aurora kinase inhibitor CCT241736 in preclinical and human in vitro models: Implication for the choice of toxicology species. European Journal of Pharmaceutical Sciences 139, pages 104899.
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Monika Lavan, Stephen R. Byrn & Gregory Knipp. (2019) Pediatric Formulations: Knowledge Gaps Limiting the Expedited Preclinical to Clinical Translation in Children. AAPS PharmSciTech 20:2.
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Xiangqian Liu, Ting Peng & He Li. (2018) Using Huntingtin Knock-In Minipigs to Fill the Gap Between Mouse Models and Patients with Huntington’s Disease. Neuroscience Bulletin 34:5, pages 870-872.
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