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Expert Opinion on Drug Discovery Volume 16, 2021 - Issue 11
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Review

An overview of rational design of mRNA-based therapeutics and vaccines

Kenneth K.W. Toa School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-2755-0283
ORCID Icon &
William C.S. Chob Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong, ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-4174-4586
ORCID Icon
Pages 1307-1317 | Received 21 Dec 2020, Accepted 25 May 2021, Published online: 19 Jul 2021

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Wubetu Yihunie, Getinet Nibret & Yibeltal Aschale. (2023) Recent Advances in Messenger Ribonucleic Acid (mRNA) Vaccines and Their Delivery Systems: A Review. Clinical Pharmacology: Advances and Applications 15, pages 77-98.
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Lin Wang, Huanchun Xing, Shuai Guo, Wenbin Cao, Zinan Zhang, Lijuan Huang, Sui Xin, Yuan Luo, Yongan Wang & Jun Yang. (2023) Negatively charged phospholipids doped liposome delivery system for mRNA with high transfection efficiency and low cytotoxicity. Drug Delivery 30:1.
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Peixian Chen, Xiaoye Shi, Weixin He, Guowei Zhong, Yan Tang, Hailin Wang & Peidong Zhang. (2022) mRNA vaccine-a desirable therapeutic strategy for surmounting COVID-19 pandemic. Human Vaccines & Immunotherapeutics 18:1.
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Articles from other publishers (15)

Xiao Guo, Dongying Liu, Yukai Huang, Youcai Deng, Ying Wang, Jingrui Mao, Yuancheng Zhou, Yongai Xiong & Xinghong Gao. (2023) Revolutionizing viral disease vaccination: the promising clinical advancements of non-replicating mRNA vaccines. Virology Journal 20:1.
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Sean D. McCarthy, Christopher B. RohdeMatt AngelClaire H. MastersonRonan MacLoughlin, Juan FandiñoHéctor E. GonzálezDeclan ByrnesJohn G. LaffeyDaniel O'Toole. (2023) Aerosolized Pulmonary Delivery of mRNA Constructs Attenuates Severity of Escherichia coli Pneumonia in the Rat . Nucleic Acid Therapeutics 33:2, pages 148-158.
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Malgorzata Ewa Rogalska, Claudia Vivori & Juan Valcárcel. (2022) Regulation of pre-mRNA splicing: roles in physiology and disease, and therapeutic prospects. Nature Reviews Genetics 24:4, pages 251-269.
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Huan-Huan Wei, Liangliang Zheng & Zefeng Wang. (2023) mRNA therapeutics: New vaccination and beyond. Fundamental Research.
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Divya Sharma, Tracey Baas, Aitor Nogales, Luis Martinez-Sobrido & M Michael Gromiha. (2023) CoDe: a web-based tool for codon deoptimization. Bioinformatics Advances 3:1.
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Theofanis Vavilis, Eleni Stamoula, Alexandra Ainatzoglou, Athanasios Sachinidis, Malamatenia Lamprinou, Ioannis Dardalas & Ioannis S. Vizirianakis. (2023) mRNA in the Context of Protein Replacement Therapy. Pharmaceutics 15:1, pages 166.
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Luca Volpini, Federica Monaco, Lory Santarelli, Jiri Neuzil & Marco Tomasetti. (2023) Advances in RNA cancer therapeutics: New insight into exosomes as miRNA delivery. Aspects of Molecular Medicine 1, pages 100005.
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Hiroshi Nakayama, Yuko Nobe, Masami Koike & Masato Taoka. (2022) Liquid Chromatography–Mass Spectrometry-Based Qualitative Profiling of mRNA Therapeutic Reagents Using Stable Isotope-Labeled Standards Followed by the Automatic Quantitation Software Ariadne. Analytical Chemistry.
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Seokhwan Chung, Chan Mi Lee & Miqin Zhang. (2023) Advances in nanoparticle-based mRNA delivery for liver cancer and liver-associated infectious diseases. Nanoscale Horizons 8:1, pages 10-28.
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Yangzhuo Gu, Jiangyao Duan, Na Yang, Yuxin Yang & Xing Zhao. (2022) mRNA vaccines in the prevention and treatment of diseases. MedComm 3:3.
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Jessica R. Shartouny & Anice C. Lowen. (2022) Message in a bottle: mRNA vaccination for influenza. Journal of General Virology 103:7.
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María M. Lorenzo, Aitor Nogales, Kevin Chiem, Rafael Blasco & Luis Martínez-Sobrido. (2022) Vaccinia Virus Attenuation by Codon Deoptimization of the A24R Gene for Vaccine Development. Microbiology Spectrum 10:3.
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Wanbo Tai, Xiujuan Zhang, Yang Yang, Jiang Zhu & Lanying Du. (2022) Advances in mRNA and other vaccines against MERS-CoV. Translational Research 242, pages 20-37.
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Enyue Fang, Xiaohui Liu, Miao Li, Zelun Zhang, Lifang Song, Baiyu Zhu, Xiaohong Wu, Jingjing Liu, Danhua Zhao & Yuhua Li. (2022) Advances in COVID-19 mRNA vaccine development. Signal Transduction and Targeted Therapy 7:1.
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Andreas Ouranidis, Theofanis Vavilis, Evdokia Mandala, Christina Davidopoulou, Eleni Stamoula, Catherine K. Markopoulou, Anna Karagianni & Kyriakos Kachrimanis. (2021) mRNA Therapeutic Modalities Design, Formulation and Manufacturing under Pharma 4.0 Principles. Biomedicines 10:1, pages 50.
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