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mAbs Volume 7, 2015 - Issue 5
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Engineered antibody domains with significantly increased transcytosis and half-life in macaques mediated by FcRn

Tianlei YingKey Laboratory of Medical Molecular Virology of Ministries of Education and Health; Shanghai Medical College; Fudan University; Shanghai, ChinaCorrespondence[email protected]
,
Yanping WangProtein Interactions Section; Laboratory of Experimental Immunology; Cancer and Inflammation Program; Center for Cancer Research; National Cancer Institute; National Institutes of Health; Frederick, MDUSA;Geneva Foundation; Tacoma, WAUSA
,
Yang FengProtein Interactions Section; Laboratory of Experimental Immunology; Cancer and Inflammation Program; Center for Cancer Research; National Cancer Institute; National Institutes of Health; Frederick, MDUSA
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Ponraj PrabakaranProtein Interactions Section; Laboratory of Experimental Immunology; Cancer and Inflammation Program; Center for Cancer Research; National Cancer Institute; National Institutes of Health; Frederick, MDUSA
,
Rui GongProtein Interactions Section; Laboratory of Experimental Immunology; Cancer and Inflammation Program; Center for Cancer Research; National Cancer Institute; National Institutes of Health; Frederick, MDUSA;Key Laboratory of Special Pathogens and Biosafety; Wuhan Institute of Virology; Chinese Academy of Sciences; Wuhan, Hubei, China
,
Lili WangKey Laboratory of Medical Molecular Virology of Ministries of Education and Health; Shanghai Medical College; Fudan University; Shanghai, China
,
Karalyne CrowderSNBL USA; Everett, WAUSA
&
Dimiter S DimitrovProtein Interactions Section; Laboratory of Experimental Immunology; Cancer and Inflammation Program; Center for Cancer Research; National Cancer Institute; National Institutes of Health; Frederick, MDUSA
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Pages 922-930 | Received 08 May 2015, Accepted 24 Jun 2015, Published online: 26 Aug 2015

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Shan Chung, Van Nguyen, Yuwen Linda Lin, Julien Lafrance-Vanasse, Suzie J. Scales, Kevin Lin, Rong Deng, Kathi Williams, Gizette Sperinde, Juan Jenny Li, Kai Zheng, Siddharth Sukumaran, Devin Tesar, James A. Ernst, Saloumeh Fischer, Greg A. Lazar, Saileta Prabhu & An Song. (2019) An in vitro FcRn- dependent transcytosis assay as a screening tool for predictive assessment of nonspecific clearance of antibody therapeutics in humans. mAbs 11:5, pages 942-955.
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Anke Steinmetz, François Vallée, Christian Beil, Christian Lange, Nicolas Baurin, Jochen Beninga, Cécile Capdevila, Carsten Corvey, Alain Dupuy, Paul Ferrari, Alexey Rak, Peter Wonerow, Jochen Kruip, Vincent Mikol & Ercole Rao. (2016) CODV-Ig, a universal bispecific tetravalent and multifunctional immunoglobulin format for medical applications. mAbs 8:5, pages 867-878.
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Huifang Wu, Dan Hu, Quanxiao Li, Chunyu Wang, Xiaoyi Zhu, Wei Li, Binfan Chen, Ping Ji, Keke Huang, Ailing Huang, Jinghe Huang, Dimiter S. Dimitrov, Yanling Wu & Tianlei Ying. (2023) Half-Life Extension Enhances Drug Efficacy in Adeno-Associated Virus Delivered Gene Therapy. Engineering 21, pages 203-213.
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Yibing Shi, Huifang Wu, Weiqiang Hu, Yujia Jin, Mengya Kong, Yulu Wang, Binfan Chen, Quanxiao Li, Keke Huang, Zhenlin Yang, Fuyou Li, Yanling Wu & Tianlei Ying. (2022) An antigen-strengthened dye-modified fully-human-nanobody-based immunoprobe for second near infrared bioimaging of metastatic tumors. Biomaterials 287, pages 121637.
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Sun-Hee Kim & Hee-Jin Jeong. (2021) Soluble Expression of Small Antibody Fragments against PD-L1 Using Escherichia coli with High Yield and Purity. Applied Sciences 11:19, pages 9149.
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Zhaoyong Xi, Xianglei Liu, Rui Lin, John D. Persons, Tatiana V. Ilina, Wei Li, Dimiter S. Dimitrov & Rieko Ishima. (2021) The reduced form of the antibody CH2 domain . Protein Science 30:9, pages 1895-1903.
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Cláudia Azevedo, Soraia Pinto, Sopisa Benjakul, Jeannette Nilsen, Hélder A. Santos, Giovanni Traverso, Jan Terje Andersen & Bruno Sarmento. (2021) Prevention of diabetes-associated fibrosis: Strategies in FcRn-targeted nanosystems for oral drug delivery. Advanced Drug Delivery Reviews 175, pages 113778.
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Chang Liu, Yeon Su Kim, John Hok-Nin Lowe & Shan Chung. (2021) A cell-based FcRn-dependent recycling assay for predictive pharmacokinetic assessment of therapeutic antibodies. Bioanalysis 13:14, pages 1135-1144.
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Timothy Qi & Yanguang Cao. (2021) In Translation: FcRn across the Therapeutic Spectrum. International Journal of Molecular Sciences 22:6, pages 3048.
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Lili Wang, Jiyan Xu, Yu Kong, Ruiying Liang, Wei Li, Jinyao Li, Jun Lu, Dimiter S. Dimitrov, Fei Yu, Yanling Wu & Tianlei Ying. (2019) Engineering a Novel Antibody-Peptide Bispecific Fusion Protein Against MERS-CoV. Antibodies 8:4, pages 53.
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Amita Datta-Mannan. (2019) Mechanisms Influencing the Pharmacokinetics and Disposition of Monoclonal Antibodies and Peptides. Drug Metabolism and Disposition 47:10, pages 1100-1110.
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Amita Datta-Mannan, Jeffrey Boyles, Lihua Huang, Zhaoyan Y. Jin, Amber Peariso, Anthony T. Murphy, Bernice Ellis, Nicole Douglass, Fariba Norouziyan-Cooper & Derrick R. Witcher. (2019) Engineered FcRn Binding Fusion Peptides Significantly Enhance the Half-Life of a Fab Domain in Cynomolgus Monkeys. Biotechnology Journal 14:3, pages 1800007.
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Nicholas Vance, Neelie Zacharias, Mark Ultsch, Guangmin Li, Aimee Fourie, Peter Liu, Julien LaFrance-Vanasse, James A. Ernst, Wendy Sandoval, Katherine R. Kozak, Gail Phillips, Weiru Wang & Jack Sadowsky. (2018) Development, Optimization, and Structural Characterization of an Efficient Peptide-Based Photoaffinity Cross-Linking Reaction for Generation of Homogeneous Conjugates from Wild-Type Antibodies. Bioconjugate Chemistry 30:1, pages 148-160.
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Chunpeng Yang, Xinyu Gao & Rui Gong. (2018) Engineering of Fc Fragments with Optimized Physicochemical Properties Implying Improvement of Clinical Potentials for Fc-Based Therapeutics. Frontiers in Immunology 8.
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Yanling Wu, Shibo Jiang & Tianlei Ying. (2017) Single-Domain Antibodies As Therapeutics against Human Viral Diseases. Frontiers in Immunology 8.
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Chunyu Wang, Yanling Wu, Lili Wang, Binbin Hong, Yujia Jin, Dan Hu, Gang Chen, Yu Kong, Ailing Huang, Guoqiang Hua & Tianlei Ying. (2017) Engineered Soluble Monomeric IgG1 Fc with Significantly Decreased Non-Specific Binding. Frontiers in Immunology 8.
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Hongyan Liu, Abhishek Saxena, Sachdev S. Sidhu & Donghui Wu. (2017) Fc Engineering for Developing Therapeutic Bispecific Antibodies and Novel Scaffolds. Frontiers in Immunology 8.
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Diana Spiegelberg & Johan Nilvebrant. (2017) CD44v6-Targeted Imaging of Head and Neck Squamous Cell Carcinoma: Antibody-Based Approaches. Contrast Media & Molecular Imaging 2017, pages 1-14.
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Gang Chen, Sachdev S. Sidhu & Johan Nilvebrant. 2017. Recombinant Antibodies for Infectious Diseases. Recombinant Antibodies for Infectious Diseases 79 98 .
Lu Shan, Magali Colazet, Kim L. Rosenthal, Xiang-Qing Yu, Jared S. Bee, Andrew Ferguson, Melissa M. Damschroder, Herren Wu, William F. Dall’Acqua, Ping Tsui & Vaheh Oganesyan. (2016) Generation and Characterization of an IgG4 Monomeric Fc Platform. PLOS ONE 11:8, pages e0160345.
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Yangsheng Qiu, Wei Lv, Min Xu & Yuhong Xu. (2016) Single chain antibody fragments with pH dependent binding to FcRn enabled prolonged circulation of therapeutic peptide in vivo. Journal of Controlled Release 229, pages 37-47.
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