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A bispecific antibody effectively neutralizes all four serotypes of dengue virus by simultaneous blocking virus attachment and fusion

Xin ShiInternational Joint Cancer Institute, Second Military Medical University, Shanghai, China
,
Yongqiang DengDepartment of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing, China;State Key Laboratory of Pathogen and Biosecurity, Beijing, China
,
Huajing WangInternational Joint Cancer Institute, Second Military Medical University, Shanghai, China
,
Guanghui JiDepartment of Traditional Chinese Medicine, Navy General Hospital, Beijing, China
,
Wenlong TanInternational Joint Cancer Institute, Second Military Medical University, Shanghai, China
,
Tao JiangDepartment of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing, China;State Key Laboratory of Pathogen and Biosecurity, Beijing, China
,
Xiaofeng LiDepartment of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing, China
,
Hui ZhaoDepartment of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing, China
,
Tian XiaInternational Joint Cancer Institute, Second Military Medical University, Shanghai, China
,
Yanchun MengInternational Joint Cancer Institute, Second Military Medical University, Shanghai, China
,
Chao WangInternational Joint Cancer Institute, Second Military Medical University, Shanghai, China
,
Xiaojie YuInternational Joint Cancer Institute, Second Military Medical University, Shanghai, China
,
Yang YangInternational Joint Cancer Institute, Second Military Medical University, Shanghai, China
,
Bohua LiInternational Joint Cancer Institute, Second Military Medical University, Shanghai, China;State Key Laboratory of Antibody Medicine and Targeting Therapy, Shanghai, China
,
E-De QinDepartment of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing, China
,
Jianxin DaiInternational Joint Cancer Institute, Second Military Medical University, Shanghai, China;State Key Laboratory of Antibody Medicine and Targeting Therapy, Shanghai, ChinaCorrespondence[email protected] [email protected]
,
Cheng-Feng QinDepartment of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing, China;State Key Laboratory of Pathogen and Biosecurity, Beijing, ChinaCorrespondence[email protected] [email protected]
&
Yajun GuoState Key Laboratory of Antibody Medicine and Targeting Therapy, Shanghai, China
 show all
Pages 574-584 | Received 08 Sep 2015, Accepted 25 Jan 2016, Published online: 10 Mar 2016

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Elisabeth K. Nyakatura, Alexandra Y. Soare & Jonathan R. Lai. (2017) Bispecific antibodies for viral immunotherapy. Human Vaccines & Immunotherapeutics 13:4, pages 836-842.
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Articles from other publishers (21)

Animesh Sarker, Nidhi Dhama & Rinkoo Devi Gupta. (2023) Dengue virus neutralizing antibody: a review of targets, cross-reactivity, and antibody-dependent enhancement. Frontiers in Immunology 14.
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Boon Hui Kok, Hui Ting Lim, Chin Peng Lim, Ngit Shin Lai, Chiuan Yee Leow & Chiuan Herng Leow. (2023) Dengue virus infection – a review of pathogenesis, vaccines, diagnosis and therapy. Virus Research 324, pages 199018.
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Fan Yang, Sijing Yan, Linwei Zhu, Frederick X.C. Wang, Fumin Liu, Linfang Cheng, Hangping Yao, Nanping Wu, Rufeng Lu & Haibo Wu. (2022) Evaluation of panel of neutralising murine monoclonal antibodies and a humanised bispecific antibody against influenza A(H1N1)pdm09 virus infection in a mouse model. Antiviral Research 208, pages 105462.
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Hong-Jiang Wang, Yan Guo, Meng-Jiao He, Zhong-Yu Liu, Qing Ye, Xing-Yao Huang, Yong-Qiang Deng, Xiao-Feng Li & Cheng-Feng Qin. (2022) Development of a Bicistronic Yellow Fever Live Attenuated Vaccine with Reduced Neurovirulence and Viscerotropism. Microbiology Spectrum 10:5.
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Cesar Armando Brito-Carreón, Karla Zavala-Maldonado, Erika Ivette Suárez-Andino, Randy E. David, Gerardo Perez- Ramírez, Alvaro Diaz-Badillo & María de Lourdes Muñoz. (2022) Cell membrane enolase of Aedes albopictus C6/36 cells is involved in the entrance mechanism of dengue virus (DENV). Journal of Asia-Pacific Entomology 25:2, pages 101924.
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Huiling Wei, Jie Tan, Bingjie Zhou, Xiaotong Guan, Qiaoxian Zhong & Jiaqi Wang. (2022) Charged Residue Implantation Improves the Affinity of a Cross-Reactive Dengue Virus Antibody. International Journal of Molecular Sciences 23:8, pages 4197.
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Yufeng Yu, Lulu Si & Yu Meng. 2022. Virus Entry Inhibitors. Virus Entry Inhibitors 171 197 .
Alexander Horst, Erand Smakaj, Eriberto Noel Natali, Deniz Tosoni, Lmar Marie Babrak, Patrick Meier & Enkelejda Miho. (2021) Machine Learning Detects Anti-DENV Signatures in Antibody Repertoire Sequences. Frontiers in Artificial Intelligence 4.
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V. S. Nesmeianova, D. N. Sherbakov & E. I. Kazachinskaia. (2021) Using Flavivirus-Specific Monoclonal Antibodies to Study the Antigenic Structure of Flaviviruses and Develop Anti-Flavivirus Drugs. Molecular Genetics, Microbiology and Virology 36:2, pages 57-67.
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Hang Su, Xiaohua Ye, Daniel C. Freed, Leike Li, Zhiqiang Ku, Wei Xiong, Peng Gao, Xinli Liu, Diana Montgomery, Weifeng Xu, Amy S. Espeseth, Dai Wang, Ningning Ma, Tong-Ming Fu, Ningyan Zhang & Zhiqiang An. (2021) Potent Bispecific Neutralizing Antibody Targeting Glycoprotein B and the gH/gL/pUL128/130/131 Complex of Human Cytomegalovirus. Antimicrobial Agents and Chemotherapy 65:3.
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V.S. Nesmeianova, D.N. Sherbakov & E.I. Kazachinskaia. (2021) The use of monoclonal antibodies specific to flavivirus to develop therapeutic drugs. Molecular Genetics Microbiology and Virology (Russian version) 39:2, pages 3.
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Ruta Kulkarni. 2020. Dynamics of Immune Activation in Viral Diseases. Dynamics of Immune Activation in Viral Diseases 9 41 .
Natasha D Durham, Aditi Agrawal, Eric Waltari, Derek Croote, Fabio Zanini, Mallorie Fouch, Edgar Davidson, Olivia Smith, Esteban Carabajal, John E Pak, Benjamin J Doranz, Makeda Robinson, Ana M Sanz, Ludwig L Albornoz, Fernando Rosso, Shirit Einav, Stephen R Quake, Krista M McCutcheon & Leslie Goo. (2019) Broadly neutralizing human antibodies against dengue virus identified by single B cell transcriptomics. eLife 8.
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Miriam Dibo, Eduardo C. Battocchio, Lucas M. dos Santos Souza, Matheus D. Veloso da Silva, Bruna K. Banin-Hirata, Milena M.M. Sapla, Poliana Marinello, Sérgio P.D. Rocha & Lígia C. Faccin-Galhardi. (2019) Antibody Therapy for the Control of Viral Diseases: An Update. Current Pharmaceutical Biotechnology 20:13, pages 1108-1121.
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Dan Hu, Zhongyu Zhu, Shun Li, Yongqiang Deng, Yanling Wu, Nana Zhang, Vinita Puri, Chunyu Wang, Peng Zou, Cheng Lei, Xiaolong Tian, Yulu Wang, Qi Zhao, Wei Li, Ponraj Prabakaran, Yang Feng, Jane Cardosa, Chengfeng Qin, Xiaohui Zhou, Dimiter S. Dimitrov & Tianlei Ying. (2019) A broadly neutralizing germline-like human monoclonal antibody against dengue virus envelope domain III. PLOS Pathogens 15:6, pages e1007836.
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Bing Zhou, Longfa Xu, Rui Zhu, Jixian Tang, Yangtao Wu, Ruopeng Su, Zhichao Yin, Dongxiao Liu, Yichao Jiang, Can Wen, Min You, Linlin Dai, Yu Lin, Yuanzhi Chen, Haijie Yang, Zhiqiang An, Changfa Fan, Tong Cheng, Wenxin Luo & Ningshao Xia. (2019) A bispecific broadly neutralizing antibody against enterovirus 71 and coxsackievirus A16 with therapeutic potential. Antiviral Research 161, pages 28-35.
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Bushra Husain & Diego Ellerman. (2018) Expanding the Boundaries of Biotherapeutics with Bispecific Antibodies. BioDrugs 32:5, pages 441-464.
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Kimberly A. DowdTheodore C. Pierson. (2018) The Many Faces of a Dynamic Virion: Implications of Viral Breathing on Flavivirus Biology and Immunogenicity. Annual Review of Virology 5:1, pages 185-207.
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E. A. Vasilenko, V. V. Mokhonov, E. N. Gorshkova & I. V. Astrakhantseva. (2018) Bispecific Antibodies: Formats and Areas of Application. Molecular Biology 52:3, pages 323-334.
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Rekha Khandia, Ashok Munjal, Kuldeep Dhama, Kumaragurubaran Karthik, Ruchi Tiwari, Yashpal Singh Malik, Raj Kumar Singh & Wanpen Chaicumpa. (2018) Modulation of Dengue/Zika Virus Pathogenicity by Antibody-Dependent Enhancement and Strategies to Protect Against Enhancement in Zika Virus Infection. Frontiers in Immunology 9.
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Meihui Xu, Roland Zuest, Sumathy Velumani, Farhana Tukijan, Ying Xiu Toh, Ramapraba Appanna, Ern Yu Tan, Daniela Cerny, Paul MacAry, Cheng-I Wang & Katja Fink. (2017) A potent neutralizing antibody with therapeutic potential against all four serotypes of dengue virus. npj Vaccines 2:1.
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