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mAbs Volume 9, 2017 - Issue 5
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Inhibition of HER3 activation and tumor growth with a human antibody binding to a conserved epitope formed by domain III and IV

Lisa C. SchmittInstitute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, GermanyORCID Iconhttp://orcid.org/0000-0003-2593-1285
ORCID Icon,
Alexander RauInstitute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany
,
Oliver SeifertInstitute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, GermanyORCID Iconhttp://orcid.org/0000-0003-1876-4212
ORCID Icon,
Jonas HonerInstitute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany
,
Meike HuttInstitute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, GermanyORCID Iconhttp://orcid.org/0000-0002-5696-2140
ORCID Icon,
Simone SchmidInstitute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany
,
Jonas ZantowInstitute of Biochemistry, Biotechnology and Bioinformatics, Technische Universität Braunschweig, Braunschweig, Germany
,
Michael HustInstitute of Biochemistry, Biotechnology and Bioinformatics, Technische Universität Braunschweig, Braunschweig, GermanyORCID Iconhttp://orcid.org/0000-0003-3418-6045
ORCID Icon,
Stefan DübelInstitute of Biochemistry, Biotechnology and Bioinformatics, Technische Universität Braunschweig, Braunschweig, GermanyORCID Iconhttp://orcid.org/0000-0001-8811-7390
ORCID Icon,
Monilola A. OlayioyeInstitute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany;Stuttgart Research Center Systems Biology, University of Stuttgart, Stuttgart, GermanyORCID Iconhttp://orcid.org/0000-0003-1093-263X
ORCID Icon &
Roland E. KontermannInstitute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany;Stuttgart Research Center Systems Biology, University of Stuttgart, Stuttgart, GermanyCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0001-7139-1350
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Pages 831-843 | Received 18 Nov 2016, Accepted 07 Apr 2017, Published online: 06 Jun 2017

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Lennart Kühl, Nadine Aschmoneit, Roland E. Kontermann & Oliver Seifert. (2022) The eIg technology to generate Ig-like bispecific antibodies. mAbs 14:1.
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Alexander Rau, Katharina Kocher, Mirjam Rommel, Lennart Kühl, Maximilian Albrecht, Hannes Gotthard, Nadine Aschmoneit, Bettina Noll, Monilola A. Olayioye, Roland E. Kontermann & Oliver Seifert. (2021) A bivalent, bispecific Dab-Fc antibody molecule for dual targeting of HER2 and HER3. mAbs 13:1.
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Oliver Seifert, Alexander Rau, Nadine Beha, Fabian Richter & Roland E. Kontermann. (2019) Diabody-Ig: a novel platform for the generation of multivalent and multispecific antibody molecules. mAbs 11:5, pages 919-929.
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Articles from other publishers (12)

Xueqi Hu, Dongdong Zhang, Zheng Zeng, Linjie Huang, Xiahui Lin & Shanni Hong. (2022) Aptamer-Based Probes for Cancer Diagnostics and Treatment. Life 12:11, pages 1937.
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Lucía Gandullo-Sánchez, Alberto Ocaña & Atanasio Pandiella. (2022) HER3 in cancer: from the bench to the bedside. Journal of Experimental & Clinical Cancer Research 41:1.
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Alexander Rau, Nicole Janssen, Lennart Kühl, Thomas Sell, Svetlana Kalmykova, Thomas E. Mürdter, Marc-H. Dahlke, Christine Sers, Markus Morkel, Matthias Schwab, Roland E. Kontermann & Monilola A. Olayioye. (2022) Triple Targeting of HER Receptors Overcomes Heregulin-mediated Resistance to EGFR Blockade in Colorectal Cancer. Molecular Cancer Therapeutics 21:5, pages 799-809.
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Danesh Hassani, Mahmood Jeddi-Tehrani, Parisa Yousefi, Samaneh Mansouri-Fard, Maryam Mobini, Hengameh Ahmadi-Zare, Forough Golsaz-Shirazi, Mohammad Mehdi Amiri & Fazel Shokri. (2022) Differential tumor inhibitory effects induced by HER3 extracellular subdomain-specific mouse monoclonal antibodies. Cancer Chemotherapy and Pharmacology 89:3, pages 347-361.
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Nadine Aschmoneit, Lennart Kühl, Oliver Seifert & Roland E Kontermann. (2021) Fc-comprising scDb-based trivalent, bispecific T-cell engagers for selective killing of HER3-expressing cancer cells independent of cytokine release. Journal for ImmunoTherapy of Cancer 9:11, pages e003616.
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Nadine Aschmoneit, Sophia Steinlein, Lennart Kühl, Oliver Seifert & Roland E. Kontermann. (2021) A scDb-based trivalent bispecific antibody for T-cell-mediated killing of HER3-expressing cancer cells. Scientific Reports 11:1.
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Danesh Hassani, Mohammad Mehdi Amiri, Mehdi Mohammadi, Parisa Yousefi, Mohammad Ali Judaki, Maryam Mobini, Forough Golsaz-Shirazi, Mahmood Jeddi-Tehrani & Fazel Shokri. (2021) A novel tumor inhibitory hybridoma monoclonal antibody with dual specificity for HER3 and HER2. Current Research in Translational Medicine 69:2, pages 103277.
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Takumi Yokoyama, Takehiro Ando, Rina Iwamoto, Daisuke Fuji, Mizuki Yamamoto & Takashi Kawakami. (2021) A human epidermal growth factor receptor 3/heregulin interaction inhibitor aptamer discovered using SELEX. Biochemical and Biophysical Research Communications 553, pages 148-153.
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Alexander Rau, Wolfgang S. Lieb, Oliver Seifert, Jonas Honer, Dennis Birnstock, Fabian Richter, Nadine Aschmoneit, Monilola A. Olayioye & Roland E. Kontermann. (2020) Inhibition of Tumor Cell Growth and Cancer Stem Cell Expansion by a Bispecific Antibody Targeting EGFR and HER3. Molecular Cancer Therapeutics 19:7, pages 1474-1485.
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Oliver Seifert & Roland E. Kontermann. (2020) Db-Igs — eine Plattform zur Herstellung multispezifischer Antikörper. BIOspektrum 26:3, pages 276-278.
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Nicola Fenderico, Revina C. van Scherpenzeel, Michael Goldflam, Davide Proverbio, Ingrid Jordens, Tomica Kralj, Sarah Stryeck, Tarek Z. Bass, Guy Hermans, Christopher Ullman, Teodor Aastrup, Piet Gros & Madelon M. Maurice. (2019) Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells. Nature Communications 10:1.
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André Frenzel, Jonas Kügler, Saskia Helmsing, Doris Meier, Thomas Schirrmann, Michael Hust & Stefan Dübel. (2017) Designing Human Antibodies by Phage Display. Transfusion Medicine and Hemotherapy 44:5, pages 312-318.
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