Advanced search
Publication Cover
mAbs Volume 9, 2017 - Issue 6
Submit an article Journal homepage
1,757
Views
11
CrossRef citations to date
0
Altmetric
Report

Evidence for intermolecular domain exchange in the Fab domains of dimer and oligomers of an IgG1 monoclonal antibody

Yin LuoAnalytical Research and Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Andover, USACorrespondence[email protected]
,
Stephen W. RasoAnalytical Research and Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Andover, USA
,
Judith GallantAnalytical Research and Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Andover, USA
,
Colleen SteinmeyerAnalytical Research and Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Andover, USAORCID Iconhttp://orcid.org/0000-0003-0684-0652
ORCID Icon,
Yasuko MabuchiAnalytical Research and Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Andover, USA
,
Zhaojiang LuAnalytical Research and Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Andover, USA
,
Clifford EntricanAnalytical Research and Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Andover, USA
&
Jason C. RouseAnalytical Research and Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Andover, USA
 show all
Pages 916-926 | Received 21 Mar 2017, Accepted 13 May 2017, Published online: 05 Jul 2017

Citations (11)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Michael J. Knight, Léontine Floret, Nisha Patel, John O’Hara & Elizabeth Rodriguez. (2022) The impact of forced degradation conditions on mAb dimer formation and subsequent influence on aggregation propensity. mAbs 14:1.
Read now
Lila Kashi, Katharina Yandrofski, Renae J. Preston, Luke W. Arbogast, John P. Giddens, John P. Marino, John E. Schiel & Zvi Kelman. (2018) Heterologous recombinant expression of non-originator NISTmAb. mAbs 10:6, pages 922-933.
Read now

Articles from other publishers (9)

Takahiro Sakai, Tsuyoshi Mashima, Naoya Kobayashi, Hideaki Ogata, Lian Duan, Ryo Fujiki, Kowit Hengphasatporn, Taizo Uda, Yasuteru Shigeta, Emi Hifumi & Shun Hirota. (2023) Structural and thermodynamic insights into antibody light chain tetramer formation through 3D domain swapping. Nature Communications 14:1.
Crossref
Stefanie Wachter, Thibaut Angevin, Niket Bubna, Adelene Tan, Adam Cichy, David Brown, Leslie S. Wolfe, Ryan Sappington, Edward Lilla, Luke Berry, Dane Grismer, Christian Orth, Milan Blanusa, Sigma Mostafa, Hitto Kaufmann & Karin Felderer. (2023) Application of platform process development approaches to the manufacturing of Mabcalin™ bispecifics. Journal of Biotechnology 377, pages 13-22.
Crossref
Thomas Powell, Michael J. Knight, Amanda Wood, John O’Hara & William Burkitt. (2021) Detection of Isopeptide Bonds in Monoclonal Antibody Aggregates. Pharmaceutical Research 38:9, pages 1519-1530.
Crossref
Donald J. AbrahamYao‐ming Huang, Brian Bowes, Tzung‐Horng Yang, James N. Thomas, S. Sam Guhan & Dean K. Pettit. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 1 68 .
Serene W Chen & Wei Zhang. (2021) Current trends and challenges in the downstream purification of bispecific antibodies. Antibody Therapeutics 4:2, pages 73-88.
Crossref
Cheng-Chung Lee, Yu-Cheng Su, Tzu-Ping Ko, Li-Ling Lin, Chih-Ya Yang, Stanley Shi-Chung Chang, Steve R. Roffler & Andrew H.-J. Wang. (2020) Structural basis of polyethylene glycol recognition by antibody. Journal of Biomedical Science 27:1.
Crossref
Gaili Guo, Jinyu Han, Ying Wang & Yifeng Li. (2020) A potential downstream platform approach for WuXiBody-based IgG-like bispecific antibodies. Protein Expression and Purification 173, pages 105647.
Crossref
Steven A. Berkowitz. 2020. Biophysical Characterization of Proteins in Developing Biopharmaceuticals. Biophysical Characterization of Proteins in Developing Biopharmaceuticals 459 479 .
Yifeng Li, Ying Wang, Peter (Keqiang) Shen & Weichang Zhou. 2020. Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics. Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics 167 179 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.