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Evidence for intermolecular domain exchange in the Fab domains of dimer and oligomers of an IgG1 monoclonal antibody

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Pages 916-926 | Received 21 Mar 2017, Accepted 13 May 2017, Published online: 05 Jul 2017

References

  • Rosenberg AS. Effects of protein aggregates: an immunologic perspective. AAPS J 2006; 8:E501-E7; PMID:17025268; https://doi.org/10.1208/aapsj080359
  • Bachmann MF, Fehr T, Freer G, Hengartner H, Zinkernagel RM. Correlation of tolerogenicity of a viral antigen with its immunogenicity. J Immunol 1997; 158:5106-11; PMID:9164925
  • Dintzis RZ, Middleton MH, Dintzis HM. Studies on the immunogenicity and tolerogenicity of T-independent antigens. J Immunol 1983; 131:2196-203; PMID:6631009
  • Henney CS, Ellis EF. Antibody production to aggregated human gamma-G-globulin in acquired hypogammaglobulinemia. N Engl J Med 1968; 278:1144-6; PMID:4171617; https://doi.org/10.1056/NEJM196805232782104
  • Joubert M, Hokom M, Eakin C, Zhou L, Deshpande M, Baker MP, Goletz TJ, Kerwin BA, Chirmule N, Narhi LO, et al. Highly aggregated antibody therapeutics can enhance the in vitro innate and late-stage T-cell immune responses. J Biol Chem 2012; 287:25266-79; PMID:22584577; https://doi.org/10.1074/jbc.M111.330902
  • Joubert MK, Luo Q, Nashed-Samuel Y, Wypych J, Narhi LO. Classification and characterization of therapeutic antibody aggregates. J Biol Chem 2011; 286:25118-33; PMID:21454532; https://doi.org/10.1074/jbc.M110.160457
  • Luo Q, Joubert M, Stevenson R, Ketchem RR, Narhi LO, Wypych J. Chemical modifications in therapeutic protein aggregates generated under different stress conditions. J Biol Chem 2011; 286:25134-44; PMID:21518762; https://doi.org/10.1074/jbc.M110.160440
  • Moussa EM, Panchal JP, Moorthy BS, Blum JS, Joubert MK, Narhi LO, Topp EM. Immunogenicity of therapeutic protein aggregates. J Pharm Sci 2016; 105:417-30; PMID:26869409; https://doi.org/10.1016/j.xphs.2015.11.002
  • Luo Y, Lu Z, Raso SW, Entrican E, Tangarone B. Dimers and multimers of monoclonal IgG1 exhibit higher in vitro binding affinities to Fcγ receptors. mAbs 2009; 1:491-504; PMID:20065648; https://doi.org/10.4161/mabs.1.5.9631
  • Liu Y, Hart PJ, Schlunegger MP, Eisenberg D. The crystal structure of a 3D domain-swapped dimer of RNase A at a 2.1-A resolution. Proc Natl Acad Sci USA 1998; 95:3437-42; PMID:9520384; https://doi.org/10.1073/pnas.95.7.3437
  • Wang T, Joshi SB, Kumru OS, Telikepalli S, Middaugh CR, Volkin DB. Case studies applying biophysical techniques to better characterize protein aggregates and particulates of varying size, in Biophysics for Therapeutic Protein Development, Narhi LO, Editor. 2013, Springer New York. p. 205-43; https://doi.org/10.1007/978-1-4614-4316-2_9
  • McConkey EH. Molecular evolution, intracellular organization, and the quinary structure of proteins. Proc Natl Acad Sci USA 1982; 79:3236-40; PMID:6954476; https://doi.org/10.1073/pnas.79.10.3236
  • Wirth AJ, Gruebele M. Quinary protein structure and the consequences of crowding in living cells: leaving the test-tube behind. Bioessays 2013; 35:984-93; PMID:23943406; https://doi.org/10.1002/bies.201300080
  • Edelstein SJ. Patterns in the quinary structures of proteins. Plasticity and inequivalence of individual molecules in helical arrays of sickle cell hemoglobin and tubulin. Biophys J 1980; 32:347-60; PMID:7248453; https://doi.org/10.1016/S0006-3495(80)84961-7
  • Srere PA. The metabolon. Trends Biochem Sci 1985; 10:109-10; https://doi.org/10.1016/0968-0004(85)90266-X
  • Monteith WB, Cohen RD, Smith AE, Guzman-Cisneros E. Quinary structure modulates protein stability in cells. Proc Natl Acad Sci USA 2015; 112:1739-42; PMID:25624496; https://doi.org/10.1073/pnas.1417415112
  • Chen K, Long DS, Lute SC, Levy MJ, Brorson KA, Keire DA. Simple NMR methods for evaluating higher order structures of monoclonal antibody therapeutics with quinary structure. J Pharm Biomed Anal 2016; 128:398-407; PMID:27344629; https://doi.org/10.1016/j.jpba.2016.06.007
  • Sun S, Luo Y, Jennings P. Purification of acidic proteins using ceramic hydroxyapatite chromatography, U.S. Patent number US008058407B2, 2011, Wyeth LLC: USA.
  • Brandis JF, Hunt L. The thermodynamics of protein denaturation. III. The denaturation of ribonuclease in water and in aqueous urea and aqueous ethonal mixtures. J Am Chem Soc 1967; 89:4826-38; PMID:6074801; https://doi.org/10.1021/ja00995a002
  • Lamoyi E. Preparation of F(ab')2 fragments from mouse IgG of various subclasses. Methods Enzymol 1986; 121:652-63; PMID:3088385; https://doi.org/10.1016/0022-1759(83)90415-5
  • Calarese DA, Scanlan CN, Zwick MB, Deechongkit S, Mimura Y, Kunert R, Zhu P, Wormald MR, Stanfield RL, Roux KH, et al. Antibody domain exchange is an immunological solution to carbohydrate cluster recognition. Science 2003; 300:2065-71; PMID:12829775; https://doi.org/10.1126/science.1083182
  • Ding F, Prutzman KC, Campbell SL, Dokholyan NV. Topological Determinants of Protein Domain Swapping. Structure 2006; 14:5-14; https://doi.org/10.1016/j.str.2005.09.008
  • Green SM, Gittis AG, Meeker AK, Lattman EE. One-step evolution of a dimer from a monomeric protein. Nat Struct Biol 1995; 2:746-15; PMID:7552745; https://doi.org/10.1038/nsb0995-746
  • Yang F, Bewley CA, Louis JM, Gustafson KR, Boyd MR, Gronenborn AM, Clore GM, Wlodawer A. Crystal structure of cyanovirin-N, a potent HIV-inactivating protein, shows unexpected domain swapping. J Mol Biol 1999; 288:403-12; PMID:10329150; https://doi.org/10.1006/jmbi.1999.2693
  • Kundu S, Jernigan RL. Molecular mechanism of domain swapping in proteins: An analysis of slower motions. Biophys J 2004; 86:3846-54; PMID:15189881; https://doi.org/10.1529/biophysj.103.034736
  • Khazanovich N, Bateman K, Chernaia M, Michalak M, James M. Crystal structure of the yeast cell-cycle control protein, p13suc1, in a strand-exchanged dimer. Structure 1996; 4:299-309; PMID:8805536; https://doi.org/10.1016/S0969-2126(96)00034-2
  • Liu Y, Eisenberg D. 3D domain swapping: As domains continue to swap. Protein Sci 2002; 11:1285-99; PMID:12021428; https://doi.org/10.1110/ps.0201402
  • Wu AM, Tan GJ, Sherman MA, Clarke P, Olafsen T, Forman SJ, Raubitschek AA. Multimerization of a chimeric anti-CD20 single-chain Fv-Fc fusion protein is mediated through variable domain exchange. Protein Engineering 2001; 14(12):1025-33; https://doi.org/10.1093/protein/14.12.1025
  • Zegers I, Deswarte J, Wyns L. Trimeric domain-swapped barnase. Proc Natl Acad Sci USA 1999; 96:818-22; PMID:9927651; https://doi.org/10.1073/pnas.96.3.818
  • Plath F, Ringler P, Graff-Meyer A, Stahlberg H, Lauer ME, Rufer AC, Graewert MA, Svergun D, Gellermann G, Finkler C, et al. Characterization of mAb dimers reveals predominant dimer forms common in therapeutic mAbs. mAbs 2016; 8:928-40; PMID:27031922; https://doi.org/10.1080/19420862.2016.1168960
  • Roux KH, Zhu P, Seavy M, Katinger H, Kunert R, Seamon V. Electron microscopic and immunochemical analysis of the broadly neutralizing HIV-1-specific, anti-carbohydrate antibody, 2G12. J Mol Immunol 2004; 41:1001-11; https://doi.org/10.1016/j.molimm.2004.05.008
  • Trkola A, Purtscher M, Muster T, Ballaun C, Buchacher A, Sullivan N, Srinivasan K, Sodroski J, Moore JP, Katinger H. Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1. J Virol 1996; 70:1100-8; PMID:8551569
  • Sterner E, Flanagan N, Gildersleeve JC. Perspectives on anti-glycan antibodies gleaned from development of a community resource database. ACS Chem Biol 2016; 11:1773-83; PMID:27220698; https://doi.org/10.1021/acschembio.6b00244

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