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mAbs Volume 9, 2017 - Issue 7
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Brief Report

Nonspecificity in a nonimmune human scFv repertoire

Ryan L. KellyDepartment of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, U.S.A.
,
Jessie ZhaoDepartment of Chemical Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, U.S.A.
,
Doris LeDepartment of Chemical Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, U.S.A.
&
K. Dane WittrupDepartment of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, U.S.A.;Department of Chemical Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, U.S.A.Correspondence[email protected]
Pages 1029-1035 | Received 13 Apr 2017, Accepted 11 Jul 2017, Published online: 18 Sep 2017

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Hristo L. Svilenov, Paolo Arosio, Tim Menzen, Peter Tessier & Pietro Sormanni. (2023) Approaches to expand the conventional toolbox for discovery and selection of antibodies with drug-like physicochemical properties. mAbs 15:1.
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Beichen Gao, Jiami Han & Sai T. Reddy. (2022) Learning what not to select for in antibody drug discovery. Cell Reports Methods 2:7, pages 100258.
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Maxime Lecerf, Alexia Kanyavuz, Sofia Rossini & Jordan D. Dimitrov. (2021) Interaction of clinical-stage antibodies with heme predicts their physiochemical and binding qualities. Communications Biology 4:1.
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Manali S. Sawant, Craig N. Streu, Lina Wu & Peter M. Tessier. (2020) Toward Drug-Like Multispecific Antibodies by Design. International Journal of Molecular Sciences 21:20, pages 7496.
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Thuy Duong Nguyen, Teruyuki Nagamune & Masahiro Kawahara. (2018) A Suicide Switch Directly Eliminates Intracellular scFv Oligomers in the Cytoplasm of Mammalian Cells. Biotechnology Journal 14:1.
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Lilia A Rabia, Yulei Zhang, Seth D Ludwig, Mark C Julian & Peter M Tessier. (2018) Net charge of antibody complementarity-determining regions is a key predictor of specificity. Protein Engineering, Design and Selection 31:11, pages 409-418.
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