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Structure and characterization of a high affinity C5a monoclonal antibody that blocks binding to C5aR1 and C5aR2 receptors

Caroline S. ColleyAntibody Discovery and Protein Engineering, MedImmune Ltd, Cambridge, UKCorrespondence[email protected]
,
Bojana PopovicAntibody Discovery and Protein Engineering, MedImmune Ltd, Cambridge, UK
,
Sudharsan SridharanAntibody Discovery and Protein Engineering, MedImmune Ltd, Cambridge, UK
,
Judit E. DebreczeniDiscovery Sciences, AstraZeneca R&D, Cambridge, UK
,
David HargeavesDiscovery Sciences, AstraZeneca R&D, Cambridge, UK
,
Michael FungRespiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, MD, USA
,
Ling–Ling AnRespiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, MD, USA
,
Bryan EdwardsAntibody Discovery and Protein Engineering, MedImmune Ltd, Cambridge, UK
,
Joanne ArnoldAntibody Discovery and Protein Engineering, MedImmune Ltd, Cambridge, UK
,
Elizabeth EnglandAntibody Discovery and Protein Engineering, MedImmune Ltd, Cambridge, UK
,
Laura EghobamienRespiratory, Inflammation and Autoimmunity, MedImmune Ltd, Cambridge, UK
,
Ulf SivarsTranslational Biology, IMED RIA Biotech Unit, AstraZeneca, Gothenburg, Sweden
,
Liz FlavellDiscovery Sciences, AstraZeneca R&D, Cambridge, UK
,
Jonathan RenshawDiscovery Sciences, AstraZeneca R&D, Cambridge, UK
,
Kate WicksonDiscovery Sciences, AstraZeneca R&D, Cambridge, UK
,
Paul WarrenerInfectious Diseases, MedImmune LLC, Gaithersburg, MD, USA
,
Jingying ZhaInfectious Diseases, MedImmune LLC, Gaithersburg, MD, USA
,
Jessica BonnellInfectious Diseases, MedImmune LLC, Gaithersburg, MD, USA
,
Rob WoodsAntibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, MD, USA
,
Trevor WilkinsonAntibody Discovery and Protein Engineering, MedImmune Ltd, Cambridge, UK
,
Claire DobsonAntibody Discovery and Protein Engineering, MedImmune Ltd, Cambridge, UK
&
Tristan J. VaughanAntibody Discovery and Protein Engineering, MedImmune Ltd, Cambridge, UK
 show all
Pages 104-117 | Received 14 Aug 2017, Accepted 22 Sep 2017, Published online: 24 Oct 2017

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Richa Mishra, Lalita Mohan Behera & Soumendra Rana. (2022) Binding of raloxifene to human complement fragment 5a (hC5a): a perspective on cytokine storm and COVID19. Journal of Biomolecular Structure and Dynamics 40:3, pages 982-994.
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Aurosikha Das, Lalita Mohan Behera & Soumendra Rana. (2021) Interaction of Human C5a with the Major Peptide Fragments of C5aR1: Direct Evidence in Support of “Two-Site” Binding Paradigm. ACS Omega 6:35, pages 22876-22887.
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Sandor Vajda, Kathryn A Porter & Dima Kozakov. (2021) Progress toward improved understanding of antibody maturation. Current Opinion in Structural Biology 67, pages 226-231.
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Min Hu, Guangbo Kang, Xin Cheng, Jiewen Wang, Ruowei Li, Zixuan Bai, Dong Yang & He Huang. (2020) In vitro affinity maturation to improve the efficacy of a hypoxia-inducible factor 1α single-domain intrabody. Biochemical and Biophysical Research Communications 529:4, pages 936-942.
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Mark L. Chiu, Dennis R. Goulet, Alexey Teplyakov & Gary L. Gilliland. (2019) Antibody Structure and Function: The Basis for Engineering Therapeutics. Antibodies 8:4, pages 55.
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Richa Mishra & Soumendra Rana. (2019) A rational search for discovering potential neutraligands of human complement fragment 5a (hC5a). Bioorganic & Medicinal Chemistry 27:19, pages 115052.
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Daniel A. Cannon, Lu Shan, Qun Du, Lena Shirinian, Keith W. Rickert, Kim L. Rosenthal, Martin Korade, Lilian E. van Vlerken-Ysla, Andrew Buchanan, Tristan J. Vaughan, Melissa M. Damschroder & Bojana Popovic. (2019) Experimentally guided computational antibody affinity maturation with de novo docking, modelling and rational design. PLOS Computational Biology 15:5, pages e1006980.
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Yuanyuan Ma, Yanqun Liu, Zhijun Zhang & Guo-Yuan Yang. (2019) Significance of Complement System in Ischemic Stroke: A Comprehensive Review. Aging and disease 10:2, pages 429.
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Wang Yuxuan. (2019) Important roles of C5a and C5aR in tumor development and cancer treatment. E3S Web of Conferences 136, pages 06012.
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