mAbs, Volume 10, Issue 1 (2018)

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mAbs, Volume 10, Issue 1 (2018)

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Perspective

Article Commentary
Safety testing of monoclonal antibodies in non-human primates: Case studies highlighting their impact on human risk assessment
Frank R. Brennan PhD, UCB Pharma, Joy Cavagnaro, Kathleen McKeever, Patricia C. Ryan, Melissa M. Schutten, John Vahle, Gerhard F. Weinbauer, Estelle Marrer-Berger & Lauren E. Black
Pages: 1-17
Published online: 26 Oct 2017
AbstractforSafety testing of monoclonal antibodies in non-human primates: Case studies highlighting their impact on human risk assessment | Full Text | References | PDF (502.9 KB)
  • 5821 Views
  • 28 CrossRef citations
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Review

Review
Practical considerations in clinical strategy to support the development of injectable drug-device combination products for biologics
Zhaoyang Li PhD & Rachael Easton MD, PhD
Pages: 18-33
Published online: 07 Nov 2017
AbstractforPractical considerations in clinical strategy to support the development of injectable drug-device combination products for biologics | Full Text | References | PDF (664.2 KB)
  • 11365 Views
  • 25 CrossRef citations
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Open Access

Reviews

Review
Personalized medicine with biologics for severe type 2 asthma: current status and future prospects
Marie Godar, Christophe Blanchetot, Hans de Haard, Bart N. Lambrecht & Guy Brusselle
Pages: 34-45
Published online: 14 Nov 2017
AbstractforPersonalized medicine with biologics for severe type 2 asthma: current status and future prospects | Full Text | References | PDF (806.7 KB) | Supplemental
  • 6625 Views
  • 58 CrossRef citations
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Review

Review
Enhanced immunization techniques to obtain highly specific monoclonal antibodies
Rodrigo de Almeida, Cecília Naomi Nakamura, Marina de Lima Fontes, Elenice Deffune, Sérgio Luis Felisbino, Ramon Kaneno, Wagner José Fávaro, Athanase Billis, Marcel Otavio Cerri, Ana Marisa Fusco-Almeida, Maria José Mendes Giannini & Andrei Moroz
Pages: 46-54
Published online: 06 Oct 2017
AbstractforEnhanced immunization techniques to obtain highly specific monoclonal antibodies | Full Text | References | PDF (761.6 KB)
  • 6936 Views
  • 12 CrossRef citations
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Open Access

Brief Report

Brief Report
Tolerability, response and outcome of high-risk neuroblastoma patients treated with long-term infusion of anti-GD2 antibody ch14.18/CHO
Ina Mueller, Karoline Ehlert, Stefanie Endres, Lena Pill, Nikolai Siebert, Silke Kietz, Penelope Brock, Alberto Garaventa, Dominique Valteau-Couanet, Evelyne Janzek, Norbert Hosten, Andreas Zinke, Winfried Barthlen, Emine Varol, Hans Loibner, Ruth Ladenstein & Holger N. Lode
Pages: 55-61
Published online: 05 Dec 2017
AbstractforTolerability, response and outcome of high-risk neuroblastoma patients treated with long-term infusion of anti-GD2 antibody ch14.18/CHO | Full Text | References | PDF (638.2 KB)
  • 3881 Views
  • 46 CrossRef citations
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Brief Report
Biomeasures and mechanistic modeling highlight PK/PD risks for a monoclonal antibody targeting Fn14 in kidney disease
Xiaoying Chen, Vahid Farrokhi, Pratap Singh, Mireia Fernandez Ocana, Jenil Patel, Lih-Ling Lin, Hendrik Neubert & Joanne Brodfuehrer
Pages: 62-70
Published online: 30 Nov 2017
AbstractforBiomeasures and mechanistic modeling highlight PK/PD risks for a monoclonal antibody targeting Fn14 in kidney disease | Full Text | References | PDF (804.4 KB)
  • 1870 Views
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Report

Report
Chickens with humanized immunoglobulin genes generate antibodies with high affinity and broad epitope coverage to conserved targets
Kathryn H. Ching, Ellen J. Collarini, Yasmina N. Abdiche, Daniel Bedinger, Darlene Pedersen, Shelley Izquierdo, Rian Harriman, Lei Zhu, Robert J. Etches, Marie-Cecile van de Lavoir, William D. Harriman & Philip A. Leighton
Pages: 71-80
Published online: 02 Nov 2017
AbstractforChickens with humanized immunoglobulin genes generate antibodies with high affinity and broad epitope coverage to conserved targets | Full Text | References | PDF (987.2 KB) | Supplemental
  • 4993 Views
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Open Access
Report
Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor (FcRn) and pharmacokinetics
Nicole M. Piche-Nicholas, Lindsay B. Avery, Amy C. King, Mania Kavosi, Mengmeng Wang, Denise M. O'Hara, Lioudmila Tchistiakova & Madan Katragadda
Pages: 81-94
Published online: 03 Nov 2017
AbstractforChanges in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor (FcRn) and pharmacokinetics | Full Text | References | PDF (1.2 MB) | Supplemental
  • 6433 Views
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Reports

Report
Hydrogen/deuterium exchange mass spectrometry and computational modeling reveal a discontinuous epitope of an antibody/TL1A Interaction
Richard Y.-C. Huang, Stanley R. Krystek Jr., Nathan Felix, Robert F. Graziano, Mohan Srinivasan, Achal Pashine & Guodong Chen
Pages: 95-103
Published online: 14 Nov 2017
AbstractforHydrogen/deuterium exchange mass spectrometry and computational modeling reveal a discontinuous epitope of an antibody/TL1A Interaction | Full Text | References | PDF (1.1 MB) | Supplemental
  • 2521 Views
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Report

Report
Structure and characterization of a high affinity C5a monoclonal antibody that blocks binding to C5aR1 and C5aR2 receptors
Caroline S. Colley, Bojana Popovic, Sudharsan Sridharan, Judit E. Debreczeni, David Hargeaves, Michael Fung, Ling–Ling An, Bryan Edwards, Joanne Arnold, Elizabeth England, Laura Eghobamien, Ulf Sivars, Liz Flavell, Jonathan Renshaw, Kate Wickson, Paul Warrener, Jingying Zha, Jessica Bonnell, Rob Woods, Trevor Wilkinson, Claire Dobson & Tristan J. Vaughan
Pages: 104-117
Published online: 24 Oct 2017
AbstractforStructure and characterization of a high affinity C5a monoclonal antibody that blocks binding to C5aR1 and C5aR2 receptors | Full Text | References | PDF (1.3 MB) | Supplemental
  • 4145 Views
  • 24 CrossRef citations
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Open Access
Report
Monoclonal antibodies targeting the disintegrin-like domain of ADAMDEC1 modulates the proteolytic activity and enables quantification of ADAMDEC1 protein in human plasma
Jacob Lund, Anne Mette Elimar Bitsch, Morten Grønbech Rasch, Mari Enoksson, Linda Troeberg, Hideaki Nagase, Mette Loftager, Michael Toft Overgaard & Helle Heibroch Petersen
Pages: 118-128
Published online: 29 Nov 2017
AbstractforMonoclonal antibodies targeting the disintegrin-like domain of ADAMDEC1 modulates the proteolytic activity and enables quantification of ADAMDEC1 protein in human plasma | Full Text | References | PDF (863.5 KB) | Supplemental
  • 1303 Views
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Report
International standards for monoclonal antibodies to support pre- and post-marketing product consistency: Evaluation of a candidate international standard for the bioactivities of rituximab
Sandra Prior, Simon E. Hufton, Bernard Fox, Thomas Dougall, Peter Rigsby, Adrian Bristow & participants of the study
Pages: 129-142
Published online: 03 Nov 2017
AbstractforInternational standards for monoclonal antibodies to support pre- and post-marketing product consistency: Evaluation of a candidate international standard for the bioactivities of rituximab | Full Text | References | PDF (779.2 KB) | Supplemental
  • 4873 Views
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Report
Assessment of structural and functional similarity of biosimilar products: Rituximab as a case study
Neh Nupur, Nidhi Chhabra, Rozaleen Dash & Anurag S. Rathore
Pages: 143-158
Published online: 07 Dec 2017
AbstractforAssessment of structural and functional similarity of biosimilar products: Rituximab as a case study | Full Text | References | PDF (890.4 KB) | Supplemental
  • 8734 Views
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Report
Manufacturing history of etanercept (Enbrel®): Consistency of product quality through major process revisions
Brian Hassett, Ena Singh, Ehab Mahgoub, Julie O'Brien, Steven M. Vicik & Brian Fitzpatrick
Pages: 159-165
Published online: 29 Nov 2017
AbstractforManufacturing history of etanercept (Enbrel®): Consistency of product quality through major process revisions | Full Text | References | PDF (545 KB)
  • 6644 Views
  • 29 CrossRef citations
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Report
Variability of intended copies for etanercept (Enbrel®): Data on multiple batches of seven products
Brian Hassett, Morton Scheinberg, Gilberto Castañeda-Hernández, Mengtao Li, Uppuluri R K Rao, Ena Singh, Ehab Mahgoub, Javier Coindreau, Julie O'Brien, Steven M Vicik & Brian Fitzpatrick
Pages: 166-176
Published online: 07 Nov 2017
AbstractforVariability of intended copies for etanercept (Enbrel®): Data on multiple batches of seven products | Full Text | References | PDF (612 KB)
  • 3705 Views
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