Structure and characterization of a high affinity C5a monoclonal antibody that blocks binding to C5aR1 and C5aR2 receptors

Caroline S. ColleyAntibody Discovery and Protein Engineering, MedImmune Ltd, Cambridge, UKCorrespondence[email protected]

Bojana PopovicAntibody Discovery and Protein Engineering, MedImmune Ltd, Cambridge, UK

Sudharsan SridharanAntibody Discovery and Protein Engineering, MedImmune Ltd, Cambridge, UK

Judit E. DebreczeniDiscovery Sciences, AstraZeneca R&D, Cambridge, UK

David HargeavesDiscovery Sciences, AstraZeneca R&D, Cambridge, UK

Michael FungRespiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, MD, USA

Ling–Ling AnRespiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, MD, USA

Bryan EdwardsAntibody Discovery and Protein Engineering, MedImmune Ltd, Cambridge, UK

Joanne ArnoldAntibody Discovery and Protein Engineering, MedImmune Ltd, Cambridge, UK

Elizabeth EnglandAntibody Discovery and Protein Engineering, MedImmune Ltd, Cambridge, UK

Laura EghobamienRespiratory, Inflammation and Autoimmunity, MedImmune Ltd, Cambridge, UK

Ulf SivarsTranslational Biology, IMED RIA Biotech Unit, AstraZeneca, Gothenburg, Sweden

Liz FlavellDiscovery Sciences, AstraZeneca R&D, Cambridge, UK

Jonathan RenshawDiscovery Sciences, AstraZeneca R&D, Cambridge, UK

Kate WicksonDiscovery Sciences, AstraZeneca R&D, Cambridge, UK

Paul WarrenerInfectious Diseases, MedImmune LLC, Gaithersburg, MD, USA

Jingying ZhaInfectious Diseases, MedImmune LLC, Gaithersburg, MD, USA

Jessica BonnellInfectious Diseases, MedImmune LLC, Gaithersburg, MD, USA

Rob WoodsAntibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, MD, USA

Trevor WilkinsonAntibody Discovery and Protein Engineering, MedImmune Ltd, Cambridge, UK

Claire DobsonAntibody Discovery and Protein Engineering, MedImmune Ltd, Cambridge, UK

Tristan J. VaughanAntibody Discovery and Protein Engineering, MedImmune Ltd, Cambridge, UK

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