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mAbs Volume 10, 2018 - Issue 2
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Productive common light chain libraries yield diverse panels of high affinity bispecific antibodies

Thomas Van BlarcomOncology Research and Development, Pfizer Inc., South San Francisco, CA, USACorrespondence[email protected]
,
Kevin LindquistOncology Research and Development, Pfizer Inc., South San Francisco, CA, USAORCID Iconhttp://orcid.org/0000-0001-6059-7425
ORCID Icon,
Zea MeltonOncology Research and Development, Pfizer Inc., South San Francisco, CA, USA
,
Wai Ling CheungOncology Research and Development, Pfizer Inc., South San Francisco, CA, USA
,
Chris WagstromOncology Research and Development, Pfizer Inc., South San Francisco, CA, USA
,
Dan McDonoughOncology Research and Development, Pfizer Inc., South San Francisco, CA, USA
,
Cendy Valle OsegueraOncology Research and Development, Pfizer Inc., South San Francisco, CA, USA
,
Sheng DingOncology Research and Development, Pfizer Inc., South San Francisco, CA, USA
,
Andrea RossiOncology Research and Development, Pfizer Inc., South San Francisco, CA, USA
,
Shobha PotluriOncology Research and Development, Pfizer Inc., South San Francisco, CA, USA
,
Purnima SundarOncology Research and Development, Pfizer Inc., South San Francisco, CA, USA
,
Steven PittsOncology Research and Development, Pfizer Inc., South San Francisco, CA, USAORCID Iconhttp://orcid.org/0000-0002-9673-7394
ORCID Icon,
Marina SirotaOncology Research and Development, Pfizer Inc., South San Francisco, CA, USA
,
Meri Galindo CasasOncology Research and Development, Pfizer Inc., South San Francisco, CA, USAORCID Iconhttp://orcid.org/0000-0002-5034-1722
ORCID Icon,
Yu YanOncology Research and Development, Pfizer Inc., South San Francisco, CA, USA
,
Jeffrey JonesOncology Research and Development, Pfizer Inc., South San Francisco, CA, USA
,
Zygy Roe-ZurzOncology Research and Development, Pfizer Inc., South San Francisco, CA, USA
,
Surabhi Srivatsa SrinivasanOncology Research and Development, Pfizer Inc., South San Francisco, CA, USA
,
Wenwu ZhaiOncology Research and Development, Pfizer Inc., South San Francisco, CA, USA
,
Jaume PonsOncology Research and Development, Pfizer Inc., South San Francisco, CA, USA
,
Arvind RajpalOncology Research and Development, Pfizer Inc., South San Francisco, CA, USA
&
Javier Chaparro-RiggersOncology Research and Development, Pfizer Inc., South San Francisco, CA, USACorrespondence[email protected]
 show all
Pages 256-268 | Received 12 Oct 2017, Accepted 11 Nov 2017, Published online: 14 Dec 2017

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Jie Zhao, Liangfeng Jiang, Haodong Yang, Lan Deng, Xiaoqing Meng, Jian Ding, Sixing Yang, Le Zhao, Wei Xu, Xiaolong Wang, Zhenping Zhu & Haomin Huang. (2022) A strategy for the efficient construction of anti-PD1-based bispecific antibodies with desired IgG-like properties. mAbs 14:1.
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Dennis J. Underwood, Jeffrey Bettencourt & Zahra Jawad. (2022) The manufacturing considerations of bispecific antibodies. Expert Opinion on Biological Therapy 22:8, pages 1043-1065.
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Danyang Gong, Timothy P. Riley, Krzysztof P. Bzymek, Ana R. Correia, Danqing Li, Christopher Spahr, John H. Robinson, Ryan B. Case, Zhulun Wang & Fernando Garces. (2021) Rational selection of building blocks for the assembly of bispecific antibodies. mAbs 13:1.
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Kathryn H. Ching, Kimberley Berg, Kevin Reynolds, Darlene Pedersen, Alba Macias, Yasmina N. Abdiche, William D. Harriman & Philip A. Leighton. (2021) Common light chain chickens produce human antibodies of high affinity and broad epitope coverage for the engineering of bispecifics. mAbs 13:1.
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Zehua Sun, Chuan Chen, Wei Li, David R. Martinez, Aleksandra Drelich, Du-San Baek, Xianglei Liu, John W. Mellors, Chien-Te Tseng, Ralph S. Baric & Dimiter S. Dimitrov. (2020) Potent neutralization of SARS-CoV-2 by human antibody heavy-chain variable domains isolated from a large library with a new stable scaffold. mAbs 12:1.
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