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Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics

Robert G. BrinsonInstitute of Bioscience and Biotechnology Research, National Institute of Standards and Technology and the University of Maryland, Rockville, MD, USACorrespondence[email protected]
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John P. MarinoInstitute of Bioscience and Biotechnology Research, National Institute of Standards and Technology and the University of Maryland, Rockville, MD, USAView further author information
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Frank DelaglioInstitute of Bioscience and Biotechnology Research, National Institute of Standards and Technology and the University of Maryland, Rockville, MD, USAView further author information
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Luke W. ArbogastInstitute of Bioscience and Biotechnology Research, National Institute of Standards and Technology and the University of Maryland, Rockville, MD, USAORCID Iconhttps://orcid.org/0000-0001-6871-450XView further author information
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Ryan M. EvansApplied and Computational Mathematics Division, National Institute of Standards and Technology, Gaithersburg, MD, USAView further author information
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Anthony KearsleyApplied and Computational Mathematics Division, National Institute of Standards and Technology, Gaithersburg, MD, USAView further author information
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Geneviève GingrasCentre for Biologics Evaluation, Biologics and Genetic Therapies Directorate, Health Canada, Ottawa, ON, CanadaView further author information
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Houman GhasrianiCentre for Biologics Evaluation, Biologics and Genetic Therapies Directorate, Health Canada, Ottawa, ON, CanadaORCID Iconhttps://orcid.org/0000-0002-9646-0006View further author information
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Yves AubinCentre for Biologics Evaluation, Biologics and Genetic Therapies Directorate, Health Canada, Ottawa, ON, CanadaORCID Iconhttps://orcid.org/0000-0002-8554-0297View further author information
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Gregory K. PierensThe Centre for Advanced Imaging, The University of Queensland, St Lucia, QLD, AustraliaView further author information
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Xinying JiaThe Centre for Advanced Imaging, The University of Queensland, St Lucia, QLD, AustraliaORCID Iconhttps://orcid.org/0000-0002-2831-4605View further author information
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Mehdi MobliThe Centre for Advanced Imaging, The University of Queensland, St Lucia, QLD, AustraliaORCID Iconhttps://orcid.org/0000-0003-2420-4262View further author information
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Hamish G. GrantBio21 Molecular Science & Biotechnology Institute, The University of Melbourne, Victoria, AustraliaView further author information
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David W. KeizerBio21 Molecular Science & Biotechnology Institute, The University of Melbourne, Victoria, AustraliaView further author information
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Kristian SchweimerLehrstuhl Biopolymere, Universitaet Bayreuth, Bayreuth, GermanyView further author information
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Jonas StåhleDepartment of Organic Chemistry, Arrhenius Laboratory, Stockholm University, Stockholm, SwedenORCID Iconhttps://orcid.org/0000-0001-5657-8635View further author information
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Göran WidmalmDepartment of Organic Chemistry, Arrhenius Laboratory, Stockholm University, Stockholm, SwedenView further author information
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Edward R. ZartlerAnalytical R&D, Pfizer Essential Health, Lake Forest, IL, USAView further author information
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Chad W. LawrencePacific Northwest National Laboratory, Earth and Biological Sciences Directorate, Richland, DC, USAView further author information
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Patrick N. ReardonPacific Northwest National Laboratory, Earth and Biological Sciences Directorate, Richland, DC, USAORCID Iconhttps://orcid.org/0000-0002-6858-0086View further author information
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John R. CortPacific Northwest National Laboratory, Earth and Biological Sciences Directorate, Richland, DC, USAORCID Iconhttps://orcid.org/0000-0001-6342-6461View further author information
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Ping XuDepartment of Downstream Processing and Analytics, Human Health Therapeutics Research Centre, National Research Council of Canada, Montreal, Quebec, CanadaView further author information
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Feng NiDepartment of Downstream Processing and Analytics, Human Health Therapeutics Research Centre, National Research Council of Canada, Montreal, Quebec, CanadaView further author information
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Saeko YanakaInstitute for Molecular Science and Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences, Myodaiji, Okazaki, JapanView further author information
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Koichi KatoInstitute for Molecular Science and Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences, Myodaiji, Okazaki, JapanView further author information
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Stuart R. ParnhamDepartment of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USAORCID Iconhttps://orcid.org/0000-0002-8205-5827View further author information
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Desiree TsaoAnalytical Development, Momenta Pharmaceuticals, Cambridge, MA, USAView further author information
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Andreas BlomgrenLaboratory Unit, Swedish Medical Products Agency, Laboratory, Uppsala, SwedenORCID Iconhttps://orcid.org/0000-0001-8171-4678View further author information
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Torgny RundlöfLaboratory Unit, Swedish Medical Products Agency, Laboratory, Uppsala, SwedenORCID Iconhttps://orcid.org/0000-0001-9004-7272View further author information
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Nils TrieloffNMR-supported Structural Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, GermanyORCID Iconhttps://orcid.org/0000-0002-3530-9273View further author information
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Peter SchmiederNMR-supported Structural Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, GermanyView further author information
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Alfred RossRoche Pharmaceutical Research & Early Development, Pre-Clinical CMC, Roche Innovation Center Basel, Basel, SwitzerlandView further author information
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Ken SkidmoreAnalytical Operations, Genentech, South San Francisco, CA, USAView further author information
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Kang ChenCenter for Drug Evaluation and Research, Food and Drug Administration, Maryland, USAORCID Iconhttps://orcid.org/0000-0003-0276-2474View further author information
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David KeireCenter for Drug Evaluation and Research, Food and Drug Administration, Maryland, USAORCID Iconhttps://orcid.org/0000-0002-7767-7904View further author information
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Darón I. FreedbergCenter for Biologics Evaluation and Research, Food and Drug Administration, Maryland, USAORCID Iconhttps://orcid.org/0000-0003-1991-5174View further author information
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Thea Suter-StahelDepartment of Biology, Institute of Molecular Biology and Biophysics, ETH Zurich, Zurich, SwitzerlandView further author information
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Gerhard WiderDepartment of Biology, Institute of Molecular Biology and Biophysics, ETH Zurich, Zurich, SwitzerlandView further author information
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Gregor IlcNMR Centre, EN-FIST Centre of Excellence, Ljubljana, Slovenia;NMR Centre, National Institute of Chemistry, Ljubljana, SloveniaView further author information
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Janez PlavecNMR Centre, EN-FIST Centre of Excellence, Ljubljana, Slovenia;NMR Centre, National Institute of Chemistry, Ljubljana, SloveniaORCID Iconhttps://orcid.org/0000-0003-1570-8602View further author information
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Scott A. BradleyEli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USAView further author information
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Donna M. BaldisseriMRS – Application Science, Bruker BioSpin Corporation, Billerica, MA, USAView further author information
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Mauricio Luis SforçaBrazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, BrazilView further author information
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Ana Carolina de Mattos ZeriBrazilian Synchrotron Light Laboratory (LNLS), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, Brazil, CEPView further author information
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Julie Yu WeiProtein Product Development, Biogen Inc., Cambridge, MA, USAView further author information
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Christina M. SzaboBaxter Pharmaceuticals R&D, Baxter Healthcare, Round Lake, IL, USAORCID Iconhttps://orcid.org/0000-0003-0403-6337View further author information
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Carlos A. AmezcuaBaxter Pharmaceuticals R&D, Baxter Healthcare, Round Lake, IL, USAORCID Iconhttps://orcid.org/0000-0003-1644-8689View further author information
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John B. JordanGlobal Regulatory and R&D Policy, Amgen Inc., Thousand Oaks, CA, USAView further author information
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Mats WikströmHigher Order Structure, Attribute Sciences, Amgen Inc., Thousand Oaks, CA, USAView further author information
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Pages 94-105 | Received 12 Jul 2018, Accepted 31 Oct 2018, Published online: 22 Dec 2018

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