mAbs, Volume 11, Issue 1 (2019)

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mAbs, Volume 11, Issue 1 (2019)

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Perspective

Article Commentary
Evolution of a comprehensive, orthogonal approach to sequence variant analysis for biotherapeutics
T. Jennifer Lin, Kathryn M. Beal, Paul W. Brown, Heather S. DeGruttola, Mellisa Ly, Wenge Wang, Chia H. Chu, Robert L. Dufield, Gerald F. Casperson, James A. Carroll, Olga V. Friese, Bruno Figueroa Jr., Lisa A. Marzilli, Karin Anderson & Jason C. Rouse
Pages: 1-12
Published online: 25 Oct 2018
AbstractforEvolution of a comprehensive, orthogonal approach to sequence variant analysis for biotherapeutics | Full Text | References | PDF (1.7 MB) | EPUB
  • 5348 Views
  • 18 CrossRef citations
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Open Access

Brief Report

Brief Report
The first World Health Organization International Standard for infliximab products: A step towards maintaining harmonized biological activity
Clive Metcalfe, Thomas Dougall, Chris Bird, Peter Rigsby, Marie-Emmanuelle Behr-Gross, Meenu Wadhwa & participants of the study
Pages: 13-25
Published online: 05 Nov 2018
AbstractforThe first World Health Organization International Standard for infliximab products: A step towards maintaining harmonized biological activity | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
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Report

Report
Anti-PD1 ‘SHR-1210ʹ aberrantly targets pro-angiogenic receptors and this polyspecificity can be ablated by paratope refinement
William J.J. Finlay, James E. Coleman, Jonathan S. Edwards & Kevin S. Johnson
Pages: 26-44
Published online: 12 Dec 2018
AbstractforAnti-PD1 ‘SHR-1210ʹ aberrantly targets pro-angiogenic receptors and this polyspecificity can be ablated by paratope refinement | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
  • 9961 Views
  • 35 CrossRef citations
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Open Access
Report
Deamidation and isomerization liability analysis of 131 clinical-stage antibodies
Xiaojun Lu, R. Paul Nobrega, Heather Lynaugh, Tushar Jain, Kyle Barlow, Todd Boland, Arvind Sivasubramanian, Maximiliano Vásquez & Yingda Xu
Pages: 45-57
Published online: 10 Dec 2018
AbstractforDeamidation and isomerization liability analysis of 131 clinical-stage antibodies | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 22316 Views
  • 77 CrossRef citations
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Open Access
Report
Antigen binding allosterically promotes Fc receptor recognition
Jun Zhao, Ruth Nussinov & Buyong Ma
Pages: 58-74
Published online: 05 Oct 2018
AbstractforAntigen binding allosterically promotes Fc receptor recognition | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
  • 4390 Views
  • 41 CrossRef citations
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Open Access
Report
High-resolution glycosylation site-engineering method identifies MICA epitope critical for shedding inhibition activity of anti-MICA antibodies
T. Noelle Lombana, Marissa L. Matsumoto, Jack Bevers III, Amy M. Berkley, Evangeline Toy, Ryan Cook, Yutian Gan, Changchun Du, Peter Liu, Paul Schnier, Wendy Sandoval, Zhengmao Ye, Jill M. Schartner, Jeong Kim & Christoph Spiess
Pages: 75-93
Published online: 22 Nov 2018
AbstractforHigh-resolution glycosylation site-engineering method identifies MICA epitope critical for shedding inhibition activity of anti-MICA antibodies | Full Text | References | PDF (3.5 MB) | EPUB | Supplemental
  • 3615 Views
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Open Access
Report
Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics
Robert G. Brinson, John P. Marino, Frank Delaglio, Luke W. Arbogast, Ryan M. Evans, Anthony Kearsley, Geneviève Gingras, Houman Ghasriani, Yves Aubin, Gregory K. Pierens, Xinying Jia, Mehdi Mobli, Hamish G. Grant, David W. Keizer, Kristian Schweimer, Jonas Ståhle, Göran Widmalm, Edward R. Zartler, Chad W. Lawrence, Patrick N. Reardon, John R. Cort, Ping Xu, Feng Ni, Saeko Yanaka, Koichi Kato, Stuart R. Parnham, Desiree Tsao, Andreas Blomgren, Torgny Rundlöf, Nils Trieloff, Peter Schmieder, Alfred Ross, Ken Skidmore, Kang Chen, David Keire, Darón I. Freedberg, Thea Suter-Stahel, Gerhard Wider, Gregor Ilc, Janez Plavec, Scott A. Bradley, Donna M. Baldisseri, Mauricio Luis Sforça, Ana Carolina de Mattos Zeri, Julie Yu Wei, Christina M. Szabo, Carlos A. Amezcua, John B. Jordan & Mats Wikström
Pages: 94-105
Published online: 22 Dec 2018
AbstractforEnabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
  • 7860 Views
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Report
Comprehensive characterization of monoclonal antibody by Fourier transform ion cyclotron resonance mass spectrometry
Yutong Jin, Ziqing Lin, Qingge Xu, Cexiong Fu, Zhaorui Zhang, Qunying Zhang, Wayne A. Pritts & Ying Ge
Pages: 106-115
Published online: 22 Dec 2018
AbstractforComprehensive characterization of monoclonal antibody by Fourier transform ion cyclotron resonance mass spectrometry | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
  • 4738 Views
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Report
Comprehensive characterisation of the heterogeneity of adalimumab via charge variant analysis hyphenated on-line to native high resolution Orbitrap mass spectrometry
Florian Füssl, Anne Trappe, Ken Cook, Kai Scheffler, Oliver Fitzgerald & Jonathan Bones
Pages: 116-128
Published online: 11 Nov 2018
AbstractforComprehensive characterisation of the heterogeneity of adalimumab via charge variant analysis hyphenated on-line to native high resolution Orbitrap mass spectrometry | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
  • 8500 Views
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Report
Evaluation of similar quality attribute characteristics in SB5 and reference product of adalimumab
Nayoung Lee, JongAh Joanne Lee, Hahymn Yang, Serim Baek, Soohwan Kim, Sooshin Kim, Tongkeun Lee, Dami Song & Gwangmin Park
Pages: 129-144
Published online: 19 Oct 2018
AbstractforEvaluation of similar quality attribute characteristics in SB5 and reference product of adalimumab | Full Text | References | PDF (3.6 MB) | EPUB
  • 5757 Views
  • 35 CrossRef citations
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Report
Expression vector-derived heterogeneity in a therapeutic IgG4 monoclonal antibody
Douglas S. Rehder, Chris J. Wisniewski, Dengfeng Liu, Diya Ren, Dell Farnan & Matthew R. Schenauer
Pages: 145-152
Published online: 07 Nov 2018
AbstractforExpression vector-derived heterogeneity in a therapeutic IgG4 monoclonal antibody | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
  • 1368 Views
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Free Access
Report
Antibody-drug conjugates with HER2-targeting antibodies from synthetic antibody libraries are highly potent against HER2-positive human gastric tumor in xenograft models
Wei-Ying Kuo, Hung-Ju Hsu, Chun-Yi Wu, Hong-Sen Chen, Yu-Chi Chou, Yueh-Liang Tsou, Hung-Pin Peng, Jhih-Wei Jian, Chung-Ming Yu, Yi-Kai Chiu, Ing-Chien Chen, Chao-Ping Tung, Michael Hsiao, Chia-Lung Lin, Yong Alison Wang, Andrew H-J. Wang & An-Suei Yang
Pages: 153-165
Published online: 08 Nov 2018
AbstractforAntibody-drug conjugates with HER2-targeting antibodies from synthetic antibody libraries are highly potent against HER2-positive human gastric tumor in xenograft models | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
  • 3239 Views
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Report
Monovalent TNF receptor 1-selective antibody with improved affinity and neutralizing activity
Fabian Richter, Kirstin A. Zettlitz, Oliver Seifert, Andreas Herrmann, Peter Scheurich, Klaus Pfizenmaier & Roland E. Kontermann
Pages: 166-177
Published online: 02 Oct 2018
AbstractforMonovalent TNF receptor 1-selective antibody with improved affinity and neutralizing activity | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
  • 1912 Views
  • 14 CrossRef citations
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Report
Generation by phage display and characterization of drug-target complex-specific antibodies for pharmacokinetic analysis of biotherapeutics
Stefan Harth, Andre Ten Haaf, Christian Loew, Christian Frisch & Achim Knappik
Pages: 178-190
Published online: 05 Dec 2018
AbstractforGeneration by phage display and characterization of drug-target complex-specific antibodies for pharmacokinetic analysis of biotherapeutics | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
  • 2938 Views
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Report
Systematic development of temperature shift strategies for Chinese hamster ovary cells based on short duration cultures and kinetic modeling
Jianlin Xu, Peifeng Tang, Andrew Yongky, Barry Drew, Michael C. Borys, Shijie Liu & Zheng Jian Li
Pages: 191-204
Published online: 02 Oct 2018
AbstractforSystematic development of temperature shift strategies for Chinese hamster ovary cells based on short duration cultures and kinetic modeling | Full Text | References | PDF (2.4 MB) | EPUB
  • 5673 Views
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Report
Modulating cell culture oxidative stress reduces protein glycation and acidic charge variant formation
Stanley Chung, Jun Tian, Zhijun Tan, Jie Chen, Na Zhang, Yunping Huang, Erik Vandermark, Jongchan Lee, Michael Borys & Zheng Jian Li
Pages: 205-216
Published online: 03 Jan 2019
AbstractforModulating cell culture oxidative stress reduces protein glycation and acidic charge variant formation | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
  • 6301 Views
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Correction

Correction
Correction
Page: 217
Published online: 13 Nov 2018
CitationforCorrection | Full Text | PDF (85.2 KB) | EPUB
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