Advanced search
Publication Cover
mAbs Volume 11, 2019 - Issue 6
Submit an article Journal homepage
5,546
Views
10
CrossRef citations to date
0
Altmetric
Report

Using bispecific antibodies in forced degradation studies to analyze the structure–function relationships of symmetrically and asymmetrically modified antibodies

Adam R. EvansDiscovery and Manufacturing Sciences, Janssen Research and Development, LLC, Malvern, PA, USACorrespondence[email protected]
,
Michael T. CapaldiDiscovery and Manufacturing Sciences, Janssen Research and Development, LLC, Malvern, PA, USA
,
Geetha GoparajuDiscovery and Manufacturing Sciences, Janssen Research and Development, LLC, Malvern, PA, USAORCID Iconhttps://orcid.org/0000-0003-1041-7742
ORCID Icon,
David ColterDiscovery and Manufacturing Sciences, Janssen Research and Development, LLC, Malvern, PA, USAORCID Iconhttps://orcid.org/0000-0003-2104-0450
ORCID Icon,
Frank F. ShiDiscovery and Manufacturing Sciences, Janssen Research and Development, LLC, Malvern, PA, USAORCID Iconhttps://orcid.org/0000-0001-5990-0255
ORCID Icon,
Sarah AubertDiscovery and Manufacturing Sciences, Janssen Research and Development, LLC, Malvern, PA, USAORCID Iconhttps://orcid.org/0000-0003-1276-7703
ORCID Icon,
Lian-Chao LiDiscovery and Manufacturing Sciences, Janssen Research and Development, LLC, Malvern, PA, USA
,
Jingjie MoDiscovery and Manufacturing Sciences, Janssen Research and Development, LLC, Malvern, PA, USA
,
Michael J. LewisDiscovery and Manufacturing Sciences, Janssen Research and Development, LLC, Malvern, PA, USA
,
Ping HuDiscovery and Manufacturing Sciences, Janssen Research and Development, LLC, Malvern, PA, USA
,
Pedro AlfonsoDiscovery and Manufacturing Sciences, Janssen Research and Development, LLC, Malvern, PA, USAORCID Iconhttps://orcid.org/0000-0001-8442-1459
ORCID Icon &
Promod MehndirattaDiscovery and Manufacturing Sciences, Janssen Research and Development, LLC, Malvern, PA, USA;Analytical Development, Biologics Research and Development, Celgene Corporation, Summit, NJ, USA
 show all
Pages 1101-1112 | Received 27 Dec 2018, Accepted 06 May 2019, Published online: 04 Jun 2019

Citations (10)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Dennis J. Underwood, Jeffrey Bettencourt & Zahra Jawad. (2022) The manufacturing considerations of bispecific antibodies. Expert Opinion on Biological Therapy 22:8, pages 1043-1065.
Read now
Steffen Lippold, Alexander Knaupp, Arnoud H. de Ru, Rayman T. N. Tjokrodirijo, Peter A. van Veelen, Erwin van Puijenbroek, Steven W. de Taeye, Dietmar Reusch, Gestur Vidarsson, Manfred Wuhrer, Tilman Schlothauer & David Falck. (2021) Fc gamma receptor IIIb binding of individual antibody proteoforms resolved by affinity chromatography–mass spectrometry. mAbs 13:1.
Read now

Articles from other publishers (8)

Ziyu Jiang & Paul A. Dalby. (2023) Challenges in scaling up AAV-based gene therapy manufacturing. Trends in Biotechnology.
Crossref
Jingyue Kang, Tonglin Sun & Yan Zhang. (2022) Immunotherapeutic progress and application of bispecific antibody in cancer. Frontiers in Immunology 13.
Crossref
Yujia Ying & Huilin Li. (2022) Recent progress in the analysis of protein deamidation using mass spectrometry. Methods 200, pages 42-57.
Crossref
Ingrid Grunert, Katrin Heinrich, Juliane Ernst, Michael Hingar, Alexandre Briguet, Michael Leiss, Manfred Wuhrer, Dietmar Reusch & Patrick Bulau. (2022) Detailed Analytical Characterization of a Bispecific IgG1 CrossMab Antibody of the Knob-into-Hole Format Applying Various Stress Conditions Revealed Pronounced Stability. ACS Omega 7:4, pages 3671-3679.
Crossref
James R. Arndt, Kelly L. Wormwood Moser, Gregory Van Aken, Rory M. Doyle, Tatjana Talamantes, Daniel DeBord, Laura Maxon, George Stafford, John Fjeldsted, Bryan Miller & Melissa Sherman. (2021) High-Resolution Ion-Mobility-Enabled Peptide Mapping for High-Throughput Critical Quality Attribute Monitoring. Journal of the American Society for Mass Spectrometry 32:8, pages 2019-2032.
Crossref
Dipanwita Batabyal, Harrison Lord, Ben Ahlstrom & Mats Wikström. (2021) Determination of the experimental extinction coefficient of therapeutic proteins using the Edelhoch method. Biologicals 71, pages 42-47.
Crossref
Manali S. Sawant, Craig N. Streu, Lina Wu & Peter M. Tessier. (2020) Toward Drug-Like Multispecific Antibodies by Design. International Journal of Molecular Sciences 21:20, pages 7496.
Crossref
William S. Sawyer, Neha SrikumarJoseph CarverPhillip Y. ChuAmy ShenAnkai XuAmbrose J. WilliamsChristoph Spiess, Cong Wu, Yichin LiuJohn C. Tran. (2020) High-throughput antibody screening from complex matrices using intact protein electrospray mass spectrometry. Proceedings of the National Academy of Sciences 117:18, pages 9851-9856.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.