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mAbs Volume 12, 2020 - Issue 1
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Improved translation of stability for conjugated antibodies using an in vitro whole blood assay

Aimee Fourie-O’Donohuea Biochemical and Cellular Pharmacology Department, Genentech Inc, South San Francisco, CA, USA
,
Phillip Y. Chua Biochemical and Cellular Pharmacology Department, Genentech Inc, South San Francisco, CA, USA
,
Josefa dela Cruz Chuha Biochemical and Cellular Pharmacology Department, Genentech Inc, South San Francisco, CA, USA
,
Robert Tchelepia Biochemical and Cellular Pharmacology Department, Genentech Inc, South San Francisco, CA, USAORCID Iconhttps://orcid.org/0000-0002-7210-0380
ORCID Icon,
Siao Ping Tsaia Biochemical and Cellular Pharmacology Department, Genentech Inc, South San Francisco, CA, USA
,
John C. Trana Biochemical and Cellular Pharmacology Department, Genentech Inc, South San Francisco, CA, USA
,
William S. Sawyera Biochemical and Cellular Pharmacology Department, Genentech Inc, South San Francisco, CA, USA
,
Dian Sub BioAnalytical Sciences Department, Genentech Inc, South San Francisco, CA, USAORCID Iconhttps://orcid.org/0000-0003-4572-462X
ORCID Icon,
Carl Ngb BioAnalytical Sciences Department, Genentech Inc, South San Francisco, CA, USAORCID Iconhttps://orcid.org/0000-0003-0148-7677
ORCID Icon,
Keyang Xub BioAnalytical Sciences Department, Genentech Inc, South San Francisco, CA, USA
,
Shang-Fan Yuc In Vivo Pharmacology Department, Genentech Inc, South San Francisco, CA, USA
,
Thomas H. Pillowd Discovery Chemistry Department, Genentech Inc, South San Francisco, CA, USAORCID Iconhttps://orcid.org/0000-0001-7300-1002
ORCID Icon,
Jack Sadowskye Protein Chemistry Department, Genentech Inc, South San Francisco, CA, USA
,
Peter S. Dragovichd Discovery Chemistry Department, Genentech Inc, South San Francisco, CA, USA
,
Yichin Liua Biochemical and Cellular Pharmacology Department, Genentech Inc, South San Francisco, CA, USAORCID Iconhttps://orcid.org/0000-0003-0917-1132
ORCID Icon &
Katherine R. Kozaka Biochemical and Cellular Pharmacology Department, Genentech Inc, South San Francisco, CA, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-3751-7225
ORCID Icon show all
Article: 1715705 | Received 18 Sep 2019, Accepted 04 Jan 2020, Published online: 30 Jan 2020

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Josefa Dela Cruz Chuh, MaryAnn Go, Yvonne Chen, Jun Guo, Hanine Rafidi, Danielle Mandikian, Yonglian Sun, Zhonghua Lin, Kellen Schneider, Pamela Zhang, Rajesh Vij, Danielle Sharpnack, Pamela Chan, Cecile de la Cruz, Jack Sadowsky, Dhaya Seshasayee, James T. Koerber, Thomas H. Pillow, Gail D. Phillips, Rebecca K Rowntree, C. Andrew Boswell, Katherine R. Kozak, Andrew G. Polson, Paul Polakis, Shang-Fan Yu, Peter S. Dragovich & Nicholas J. Agard. (2021) Preclinical optimization of Ly6E-targeted ADCs for increased durability and efficacy of anti-tumor response. mAbs 13:1.
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Markus Walles, Michael Berna, Wenying Jian, Simon Hauri, Shawna Hengel, Lloyd King, John C. Tran, Cong Wei, Keyang Xu & Xiaochun Zhu. (2022) A Cross Company Perspective on the Assessment of Therapeutic Protein Biotransformation. Drug Metabolism and Disposition 50:6, pages 846-857.
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Syed Muhammad Usama, Sierra C. Marker, Donald R. Caldwell, Nimit L. Patel, Yang Feng, Joseph D. Kalen, Brad St. Croix & Martin J. Schnermann. (2021) Targeted Fluorogenic Cyanine Carbamates Enable In Vivo Analysis of Antibody–Drug Conjugate Linker Chemistry . Journal of the American Chemical Society 143:51, pages 21667-21675.
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John F. Kellie, John C. Tran, Wenying Jian, Barry Jones, John T. Mehl, Ying Ge, Jack Henion & Kevin P. Bateman. (2020) Intact Protein Mass Spectrometry for Therapeutic Protein Quantitation, Pharmacokinetics, and Biotransformation in Preclinical and Clinical Studies: An Industry Perspective. Journal of the American Society for Mass Spectrometry 32:8, pages 1886-1900.
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J. Edward FisherJr.Jr.. (2021) Considerations for the Nonclinical Safety Evaluation of Antibody–Drug Conjugates. Antibodies 10:2, pages 15.
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Peter S. Dragovich, Thomas H. Pillow, Robert A. Blake, Jack D. Sadowsky, Emel Adaligil, Pragya Adhikari, Jinhua Chen, Nicholas Corr, Josefa dela Cruz-Chuh, Geoffrey Del Rosario, Aaron Fullerton, Steven J. Hartman, Fan Jiang, Susan Kaufman, Tracy Kleinheinz, Katherine R. Kozak, Liling Liu, Ying Lu, Melinda M. Mulvihill, Jeremy M. Murray, Aimee O’Donohue, Rebecca K. Rowntree, William S. Sawyer, Leanna R. Staben, John Wai, Jian Wang, BinQing Wei, Wentao Wei, Zijin Xu, Hui Yao, Shang-Fan Yu, Donglu Zhang, Hongyan Zhang, Shenhua Zhang, Yongxin Zhao, Hao Zhou & Xiaoyu Zhu. (2021) Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy. Journal of Medicinal Chemistry 64:5, pages 2576-2607.
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Peter S. Dragovich, Thomas H. Pillow, Robert A. Blake, Jack D. Sadowsky, Emel Adaligil, Pragya Adhikari, Sunil Bhakta, Nicole Blaquiere, Jinhua Chen, Josefa dela Cruz-Chuh, Karen E. Gascoigne, Steven J. Hartman, Mingtao He, Susan Kaufman, Tracy Kleinheinz, Katherine R. Kozak, Liang Liu, Liling Liu, Qi Liu, Ying Lu, Fanwei Meng, Melinda M. Mulvihill, Aimee O’Donohue, Rebecca K. Rowntree, Leanna R. Staben, Steven T. Staben, John Wai, Jian Wang, BinQing Wei, Catherine Wilson, Jianfeng Xin, Zijin Xu, Hui Yao, Donglu Zhang, Hongyan Zhang, Hao Zhou & Xiaoyu Zhu. (2021) Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 1: Exploration of Antibody Linker, Payload Loading, and Payload Molecular Properties. Journal of Medicinal Chemistry 64:5, pages 2534-2575.
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Wilson Z. Shou. (2020) Current status and future directions of high-throughput ADME screening in drug discovery. Journal of Pharmaceutical Analysis 10:3, pages 201-208.
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