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Improved translation of stability for conjugated antibodies using an in vitro whole blood assay
Aimee Fourie-O’Donohuea Biochemical and Cellular Pharmacology Department, Genentech Inc, South San Francisco, CA, USA
, Phillip Y. Chua Biochemical and Cellular Pharmacology Department, Genentech Inc, South San Francisco, CA, USA
, Josefa dela Cruz Chuha Biochemical and Cellular Pharmacology Department, Genentech Inc, South San Francisco, CA, USA
, Robert Tchelepia Biochemical and Cellular Pharmacology Department, Genentech Inc, South San Francisco, CA, USAhttps://orcid.org/0000-0002-7210-0380
, Siao Ping Tsaia Biochemical and Cellular Pharmacology Department, Genentech Inc, South San Francisco, CA, USA
, John C. Trana Biochemical and Cellular Pharmacology Department, Genentech Inc, South San Francisco, CA, USA
, William S. Sawyera Biochemical and Cellular Pharmacology Department, Genentech Inc, South San Francisco, CA, USA
, Dian Sub BioAnalytical Sciences Department, Genentech Inc, South San Francisco, CA, USAhttps://orcid.org/0000-0003-4572-462X
, Carl Ngb BioAnalytical Sciences Department, Genentech Inc, South San Francisco, CA, USAhttps://orcid.org/0000-0003-0148-7677
, Keyang Xub BioAnalytical Sciences Department, Genentech Inc, South San Francisco, CA, USA
, Shang-Fan Yuc In Vivo Pharmacology Department, Genentech Inc, South San Francisco, CA, USA
, Thomas H. Pillowd Discovery Chemistry Department, Genentech Inc, South San Francisco, CA, USAhttps://orcid.org/0000-0001-7300-1002
, Jack Sadowskye Protein Chemistry Department, Genentech Inc, South San Francisco, CA, USA
, Peter S. Dragovichd Discovery Chemistry Department, Genentech Inc, South San Francisco, CA, USA
, Yichin Liua Biochemical and Cellular Pharmacology Department, Genentech Inc, South San Francisco, CA, USAhttps://orcid.org/0000-0003-0917-1132
& Katherine R. Kozaka Biochemical and Cellular Pharmacology Department, Genentech Inc, South San Francisco, CA, USACorrespondence[email protected]
https://orcid.org/0000-0003-3751-7225
show allhttps://orcid.org/0000-0003-3751-7225
Article: 1715705
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Received 18 Sep 2019, Accepted 04 Jan 2020, Published online: 30 Jan 2020
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