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mAbs Volume 12, 2020 - Issue 1
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Investigation of anomalous charge variant profile reveals discrete pH-dependent conformations and conformation-dependent charge states within the CDR3 loop of a therapeutic mAb

Wenkui Lana Drug Product Development, Bristol Myers Squibb, New Brunswick, United StatesCorrespondence[email protected]
,
Joseph J. Valentea Drug Product Development, Bristol Myers Squibb, New Brunswick, United States
,
Andrew Ilotta Drug Product Development, Bristol Myers Squibb, New Brunswick, United States
,
Naresh Chennamsettyb Biophysics Center of Excellence, Global Product Development and Supply, Bristol Myers Squibb, New Brunswick, United States
,
Zhihua Liua Drug Product Development, Bristol Myers Squibb, New Brunswick, United States
,
Joseph M. Rizzoc Discovery Biotherapeutics, Bristol Myers Squibb, Pennington, United States
,
Aaron P. Yamniukc Discovery Biotherapeutics, Bristol Myers Squibb, Pennington, United States
,
Difei Qiud Chemical Process Department, Bristol Myers Squibb, New Brunswick, United States
,
Holly M. Shackmand Chemical Process Department, Bristol Myers Squibb, New Brunswick, United States
&
Mark S. Bolgara Drug Product Development, Bristol Myers Squibb, New Brunswick, United States
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Article: 1763138 | Received 28 Nov 2019, Accepted 26 Apr 2020, Published online: 20 May 2020

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Shabdita Vatsa. (2022) In silico prediction of post-translational modifications in therapeutic antibodies. mAbs 14:1.
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Orla Cunningham, Martin Scott, Zhaohui Sunny Zhou & William J.J. Finlay. (2021) Polyreactivity and polyspecificity in therapeutic antibody development: risk factors for failure in preclinical and clinical development campaigns. mAbs 13:1.
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Difei Qiu, Yande Huang, Naresh Chennamsetty, Scott A. Miller & Michael Hay. (2021) Characterizing and understanding the formation of cysteine conjugates and other by-products in a random, lysine-linked antibody drug conjugate. mAbs 13:1.
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Articles from other publishers (3)

David Saleh, Rudger Hess, Michelle Ahlers‐Hesse, Nicole Beckert, Markus Schönberger, Federico Rischawy, Gang Wang, Joschka Bauer, Michaela Blech, Simon Kluters, Joey Studts & Jürgen Hubbuch. (2021) Modeling the impact of amino acid substitution in a monoclonal antibody on cation exchange chromatography. Biotechnology and Bioengineering 118:8, pages 2923-2933.
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Shih-Ting Hong, Yu-Cheng Su, Yu-Jen Wang, Tian-Lu Cheng & Yeng-Tseng Wang. (2021) Anti-TNF Alpha Antibody Humira with pH-dependent Binding Characteristics: A constant-pH Molecular Dynamics, Gaussian Accelerated Molecular Dynamics, and In Vitro Study. Biomolecules 11:2, pages 334.
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Vanessa R. Lobo & Jim Warwicker. (2021) Predicted pH-dependent stability of SARS-CoV-2 spike protein trimer from interfacial acidic groups. Computational and Structural Biotechnology Journal 19, pages 5140-5148.
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