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mAbs Volume 12, 2020 - Issue 1
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Investigation of anomalous charge variant profile reveals discrete pH-dependent conformations and conformation-dependent charge states within the CDR3 loop of a therapeutic mAb

Wenkui Lana Drug Product Development, Bristol Myers Squibb, New Brunswick, United StatesCorrespondence[email protected]
,
Joseph J. Valentea Drug Product Development, Bristol Myers Squibb, New Brunswick, United States
,
Andrew Ilotta Drug Product Development, Bristol Myers Squibb, New Brunswick, United States
,
Naresh Chennamsettyb Biophysics Center of Excellence, Global Product Development and Supply, Bristol Myers Squibb, New Brunswick, United States
,
Zhihua Liua Drug Product Development, Bristol Myers Squibb, New Brunswick, United States
,
Joseph M. Rizzoc Discovery Biotherapeutics, Bristol Myers Squibb, Pennington, United States
,
Aaron P. Yamniukc Discovery Biotherapeutics, Bristol Myers Squibb, Pennington, United States
,
Difei Qiud Chemical Process Department, Bristol Myers Squibb, New Brunswick, United States
,
Holly M. Shackmand Chemical Process Department, Bristol Myers Squibb, New Brunswick, United States
&
Mark S. Bolgara Drug Product Development, Bristol Myers Squibb, New Brunswick, United States
 show all
Article: 1763138 | Received 28 Nov 2019, Accepted 26 Apr 2020, Published online: 20 May 2020

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